Cardiovascular Disease Epidemiology in Medicaid Patients with Lupus

狼疮医疗补助患者的心血管疾病流行病学

基本信息

批准号：
9260809
负责人：
Karen H Costenbader
金额：
$ 17.59万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-15 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9260809
关键词：
Academic Training Address Affect Age Area Autoimmune Diseases Biostatistical Methods Cardiac Cardiovascular Diseases Caring Cause of Death Clinical Clinical Investigator Cohort Studies Collaborations Coronary Artery Bypass Country Data Development Disease Disease Outcome Educational process of instructing Enrollment Environment Epidemiologic Methods Epidemiology Ethnic Origin Event Feedback Fellowship Future General Population Grant Health Insurance Healthcare Heart failure Hospitals Hydroxychloroquine Inflammatory Intervention Investigation Kidney Knowledge Lupus Lupus Nephritis Medicaid Medical Mentors Methotrexate Morbidity - disease rate Myocardial Infarction Operative Surgical Procedures Outcome Outcomes Research Patients Peripheral Vascular Diseases Pharmaceutical Preparations Pharmacoepidemiology Policies Population Positioning Attribute Postdoctoral Fellow Procedures Public Health Public Health Schools Race Recruitment Activity Relative Risks Reporting Research Research Personnel Research Project Grants Research Training Resources Rheumatism Rheumatoid Arthritis Rheumatology Risk Socioeconomic Status Stroke Subgroup Systemic Lupus Erythematosus TNF gene Teaching Hospitals Testing Time Training Training Programs Uncertain Risk Variant Vulnerable Populations Woman Work adverse outcome base cardiovascular disorder risk career cohort epidemiology study high risk high risk population improved lectures medical schools mortality next generation patient oriented patient oriented research percutaneous coronary intervention population based programs public health relevance research study sex success young woman

项目摘要

DESCRIPTION (provided by applicant): Since completing her rheumatology fellowship and research training, Dr. Costenbader has devoted her career to patient-oriented rheumatic disease research. She has served as primary or secondary research mentor for 33 pre- and post-doctoral trainees. Along with her position as Co-Director of the Brigham and Women's Hospital Lupus Center, Dr. Costenbader's mentoring is facilitated by her affiliations with several Harvard teaching and training programs. Moreover, the candidate's multiple ongoing patient-oriented research projects and collaborations, commitment to mentoring, and exceptional institutional resources provide an outstanding environment for the development of junior investigators in patient-oriented rheumatic disease research. This K24 grant would preserve Dr. Costenbader's protected time and relieve future clinical and administrative responsibilities. The new research aims proposed will build upon past work in a large, nationwide lupus population with Medicaid data from 2000-2010. With data on over 66,000 lupus patients in the U.S., these studies will address key unanswered questions about cardiovascular disease risks, medical and surgical care, and outcomes. These important questions include whether cardiovascular disease risks are changing over time in this population, how post-cardiac event and intervention risks compare to those of the general population, whether lupus patients receive optimal cardiac care, and whether hydroxychloroquine reduces cardiovascular disease risks. The inherent sociodemographic variation and high medical risk of this vulnerable population make these studies extremely relevant for ongoing policy discussions about improving healthcare and outcomes. The findings of these powerful studies will inform future . Moreover, the proposed research studies will provide excellent mentoring opportunities. Dr. Costenbader will continue to recruit two to three new trainees into her rheumatic disease epidemiology and outcomes research program each year, and to expand and refine her formal mentoring program using feedback received from trainees, medical care and prescribing practices and seminars and lectures at the Brigham and Women's Hospital and Harvard Medical School. Based on institutional commitment and resources and Dr. Costenbader's successful record in research and mentoring, this K24 grant would greatly augment her ability to expand her existing research mentoring program and to develop the next generation of patient-oriented rheumatic disease investigators.

描述（由申请人提供）：自从完成其风湿病学奖学金和研究培训以来，Costenbader博士将职业生涯致力于以患者为导向的风湿病研究。她曾担任33名前和博士后学员的小学或二级研究导师。加上她的多个哈佛教学和培训计划的隶属关系，加上她担任杨百翰和妇女医院狼疮中心的联合主任的职位。此外，候选人的多个正在进行的以患者为导向的研究项目和合作，对指导的承诺以及出色的机构资源为开发以患者为导向的风湿病研究的初级调查人员提供了一个杰出的环境。这项K24赠款将保留Costenbader博士的受保护时间，并减轻未来的临床和行政责任。拟议的新研究目的将基于2000 - 2010年的医疗补助数据的大型全国狼疮人群的过去工作。在美国有超过66,000名狼疮患者的数据中，这些研究将解决有关心血管疾病风险，医疗和手术护理以及结果的关键问题。这些重要的问题包括心血管疾病的风险是否随着时间的流逝而变化，后心事件和干预风险与普通人群相比如何，狼疮患者是否获得最佳心脏护理，以及羟基氯喹是否降低心血管疾病的风险。这种脆弱人群的固有社会人口统计学差异和高医疗风险使这些研究与正在进行的有关改善医疗保健和结果的政策讨论非常相关。这些强大的研究的发现将为未来提供信息。此外，拟议的研究将提供出色的指导机会。 Costenbader博士每年将继续招募两到三名新学员进入其风湿病的流行病学和成果研究计划，并使用从学员，医疗保健和处方实践，研讨会以及在Brigham以及妇女医院和哈佛医学院接受的教育者，医疗机构以及研讨会和讲座的反馈来扩展和完善她的正式指导计划。基于机构承诺和资源以及Costenbader博士在研究和指导方面的成功记录，这项K24 Grant将大大提高她扩大现有研究指导计划的能力，并发展下一代以患者为导向的风湿病研究人员。