CSHL 2023 Conference on Systems Immunology

CSHL 2023系统免疫学会议

• 批准号: 10608272
• 负责人: DAVID J. STEWART
• 金额: $ 1万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608272
• 关键词: Acceleration; Address; Antibodies; Antigens; Atmosphere; Autoimmune; COVID-19 vaccine; Cell Communication; Cells; Collaborations; Communities; Complex; Computational Biology; Computer Models; Coupled; Coupling; Data; Data Set; Development; Dimensions; Discipline; Disease; Ensure; Environment; Event; Evolution; Faculty; Family; Financial Hardship; Fostering; Funding; Future; Genomics; Grant; Health; Human; Hybrids; Image; Immune; Immune response; Immune system; Immunologist; Immunology; Individual; Industrialization; Infection; Inflammatory; International; Laboratories; Length; Length of Stay; Lymphocyte; Malignant Neoplasms; Methodology; Methods; Minority; Modeling; Mus; Nationalities; New York; Oral; Organ; Organism; Participant; Pathogenicity; Patients; Persons; Postdoctoral Fellow; Production; Productivity; Property; Published Comment; Reagent; Recurrence; Regulation; Research; Research Institute; Research Personnel; Resolution; Resources; SARS-CoV-2 infection; Schedule; Scientist; Series; Signal Transduction; Structure; System; Systems Biology; Technology; Time; Tissues; Travel; Virus; Woman; Work; broadening participation research; career; case-by-case basis; cell behavior; cell type; computer science; data exchange; design; dimensional analysis; experimental study; fighting; graduate student; high dimensionality; immunoengineering; immunogenic; immunoregulation; innovation; mathematical model; meetings; multidimensional data; multidisciplinary; multiple omics; novel therapeutic intervention; particle; posters; rational design; receptor; response; senior faculty; social; spatiotemporal; success; symposium; synthetic biology; technology platform; tissue injury; tissue stress; unpublished works; vaccine development; virtual

Cold Spring Harbor Conference on Systems Immunology Cold Spring Harbor, NY April 18 – 22, 2023 ABSTRACT Immune responses are orchestrated by diverse cells and molecules operating over space and time and across different scales, for example, extremely complex repertoires of lymphocyte receptors can discriminate between self and non-self antigens and subsequently trigger dynamic cell-cell interactions culminating in the production of effector functions including antibodies and killing of virus infected cells. Critical discoveries have been made by experimental immunologists studying individual molecules, cells, and their interactions. Due to the complexity of the interactions among these diverse immune components, many fundamental issues associated with immune regulation and response orchestration remain unresolved. Further progress requires an integration of high-dimensional multi-omic approaches, and computational and quantitative modeling to analyze cellular behaviors at various scales of the system. These properties cannot be analyzed or intuited by conventional experiments. It is clear that effective collaborations between experimental immunologists and computational and systems biologists are required to advance our systems-level understanding of immune responses. This meeting is the third in a biennial series that catalyzing a cross-disciplinary exchange of new ideas and technologies in the rapidly evolving and expanding field of systems immunology. Building on the successes of the first two meetings held at CSHL in 2019 and 2021, have established this recurring meeting as the leading forum that can sustain a highly interactive community of Systems Immunologists. The proposed meeting will focus on recent advances at the interface of immunology and systems and computational biology, including rational design and applications of engineered immune particles and cells. Sessions will highlight multi-dimensional experimental platforms and computational approaches that are being used to analyze signaling and genomic states of individual immune cells that control discrete effector responses in a spatiotemporal manner. Integration of immunogenic, tolerogenic or pathophysiologic responses at different levels of scale – cellular, tissues and organs in mice and humans will be explored. Shared and unique design principles that underlie the development, functioning and evolution of the immune system will be discussed from an analytic standpoint. The session on Human Systems Immunology will include high-dimensional analyses of immune responses to SARS-CoV-2 infection as well as to COVID-19 vaccines. The meeting will nurture and foster a community of systems immunologists that are coupling high-dimensional profiling and imaging with computational and quantitative analyses to deepen the understanding of immune system states and responses. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include primarily graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size and we expect about 250-300 people to participate in person, the majority of whom will be presenting a poster or talk, with an additional virtual audience of 150-200 layered over to provide broadened access to those who would otherwise be unable to participate. Presenters will be expected to attend in-person with exemptions granted on a case-by-case basis. The hybrid format will allow broadened access to scientists who would otherwise be unable to attend because of travel/visa restrictions, family obligations or financial burden. The participation of young investigators, minority, and women scientists will be strongly encouraged. This proposal includes requested funding to support the participation of early career Investigators.

冷春港系统免疫学会议 纽约州冷春港 2023年4月18日至22日 抽象的 免疫反应是由在空间和时间上运行的各种细胞和分子精心策划的， 例如，在不同的尺度上，淋巴细胞受体的极其复杂的曲目可以区分 在自我和非自我抗原之间以及随后触发动态细胞 - 细胞相互作用最终导致 产生效应功能，包括抗体和杀死病毒感染细胞。批判性发现 是由研究单个分子，细胞及其相互作用的实验免疫学家制成的。由于 这些潜水员免疫成分之间的互动的复杂性，许多基本问题 与免疫调节和响应编排相关的尚未解决。进一步的进展需要 集成高维多词方法以及计算和定量建模以分析 在系统的各个尺度上的细胞行为。这些属性不能由 常规实验。显然，实验免疫学家与 需要计算和系统生物学家来提高我们的系统级别对免疫的理解 回答。这次会议是每两年一次的系列赛的第三次会议，该系列催化了新的跨学科交流 迅速发展和扩展的系统免疫学领域中的思想和技术。建立在 2019年和2021年在CSHL举行的前两次会议的成功，已建立了这次经常性会议 领先的论坛可以维持一个高度互动的系统免疫学家。 拟议的会议将重点介绍免疫学和系统界面的最新进展以及 计算生物学，包括理性设计以及工程免疫颗粒和细胞的应用。 会议将重点介绍正在的多维实验平台和正在的计算方法 用于分析控制离散效应子响应的单个免疫细胞的信号传导和基因组状态 以时空的方式。在不同 尺度水平 - 将探索小鼠和人类的细胞，组织和器官。共享和独特的设计 将从 一个分析的角度。人类系统免疫学会议将包括对 对SARS-COV-2感染以及共vid-19疫苗的免疫反应。会议将护理和 建立一个系统免疫学家社区 计算和定量分析以加深对免疫系统状态和反应的理解。 口头演讲将由一组杰出的邀请发言人以及选定的演讲者进行 来自提交的摘要。选定的演讲者将包括小学研究生，博士后研究员和 初级教师旨在最大程度地纳入年轻调查员。两张海报特别重要 会议，许多参与者可以在氛围导电中介绍他们的作品以进行非正式讨论。 会议的规模将是中等的，我们预计大多数人会参加大多数人参加 其中将介绍海报或谈话，另外150-200的虚拟受众层面以提供 扩大了那些原本无法参加的人的机会。主持人将有望参加 面对面的豁免措施。混合格式将允许扩大访问 由于旅行/签证限制，家庭义务或 财务负担。年轻的调查人员，少数群体和女科学家的参与将很强 鼓励。该提案包括要求资助以支持早期职业调查员的参与。