Texas Developmental Center for AIDS Research

德克萨斯艾滋病研究发展中心

• 批准号: 10609473
• 负责人: Thomas P Giordano
• 金额: $ 115.65万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-23 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609473
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Area; Award; Basic Science; Biomedical Research; Biometry; Biostatistics Core; California; Caring; Censuses; Clinical; Clinical Trials; Collaborations; Communication; Communities; Community Outreach; Coupled; Data; Development; Diagnosis; Environment; Epidemic; Event; Fostering; Funding; Funding Opportunities; Goals; HIV; HIV Infections; HIV diagnosis; Health; Health Insurance; Health Sciences; Health Services; Home; Human Resources; Institution; Knowledge; Leadership; Learning; Medicaid; Medicine; Mentors; Mission; Newly Diagnosed; Occupational activity of managing finances; Outcome; Persons; Pilot Projects; Policies; Population; Prevention; Procedures; Process; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Research Priority; Research Project Grants; Resource-limited setting; Resources; Risk; Scientist; Services; Strategic Planning; Texas; Training; Treatment outcome; US State; United States; United States National Institutes of Health; Universities; Viral; career; college; combat; coronavirus pandemic; federal policy; health determinants; improved; innovation; member; multidisciplinary; next generation; nonhuman primate; novel coronavirus; prevent; programs; substance use; symposium; synergism; transmission process; virology; working group

PROJECT SUMMARY – TEXAS DEVELOPMENTAL CENTER FOR AIDS RESEARCH In 2019, the US announced a plan to End the HIV Epidemic by 2030. To be successful, strategies that improve HIV prevention and HIV treatment outcomes are needed. Only 56% of people with HIV (PWH) were virally suppressed in 2018, a critical determinant of health outcomes and transmission risk, and 51% of HIV diagnoses in 2018 were in the US South, despite constituting only 38% of the population in the US. Texas is the second most populous state in the US, behind California, with about 29 million residents, and is in the US South as defined by CDC and the Census Bureau. Unfortunately, this large Texas population, coupled with weaker public health and prevention policies and funding across the US South, has a growing HIV population that lags in critical health outcomes. There is an urgent need for more research and research infrastructure to combat the HIV epidemic in the US South and specifically in Texas to both contribute to ending the US HIV epidemic and to learn how to best do that in resource constrained areas of the US. We therefore will establish a Texas Developmental Center for AIDS Research (D-CFAR) to support the overall mission of the national CFAR program by facilitating high-priority HIV research and supporting the effort to end the HIV epidemic in the US. Three institutions have collaborated to propose this D-CFAR: Baylor College of Medicine in Houston, The University of Texas Health Science Center at Houston and the Texas Biomedical Research Institute in San Antonio. Based upon the outstanding expertise of its investigators, the Texas D-CFAR will focus its activities in the five-year funding period on the research theme “Ending HIV and Optimizing HIV Health in Texas.” To accomplish its goals, the Texas D-CFAR will: 1) Provide organizational and financial management and facilitate activities and programs that strengthen and enrich the D-CFAR research and intellectual environment; 2) Support targeted high-priority interdisciplinary pilot research projects, assist in responding to new HIV-related research initiatives, and facilitate research on ending HIV and improving health of PWH in Texas; and 3) Provide state-of-the-art expertise, advice, and services to facilitate the range of HIV-related research for D-CFAR investigators. The Texas D-CFAR will support an Administrative Core, a Developmental Core, a Basic Science Core and a Clinical and Biostatistics Core to meet investigator needs and catalyze innovative research. The scientific Cores will build on outstanding strengths in virology, non-human primate resources, clinical trials research and biostatistics. The D-CFAR will engage a Community Advisory Board and Internal and External Advisory Boards for guidance. Coupled with outstanding institutional support, the D- CFAR will stimulate new research and collaborations among basic, translational, clinical, health services and public health researchers. The D-CFAR will significantly advance knowledge needed to end HIV and improve the health of PWH in Texas and similar areas, train the next generation of scientists, and grow into a full CFAR, thereby contributing to ending the HIV epidemic in Texas, the US South, and beyond.

项目摘要——德克萨斯州艾滋病研究发展中心 2019 年，美国宣布了一项到 2030 年结束艾滋病毒流行的计划。要取得成功，必须采取改善的策略 只有 56% 的艾滋病毒感染者 (PWH) 感染了病毒，因此需要艾滋病毒预防和治疗结果。 2018 年得到抑制，这是健康结果和传播风险的关键决定因素，51% 的艾滋病毒 2018 年的确诊病例集中在美国南部，尽管该州仅占美国德克萨斯州人口的 38%。 美国人口第二多的州，仅次于加利福尼亚州，拥有约 2900 万居民，位于美国境内 不幸的是，德克萨斯州人口众多，加上疾病预防控制中心和人口普查局定义的南部。 美国南部的公共卫生和预防政策及资金薄弱，艾滋病毒人口不断增加 迫切需要更多的研究和研究基础设施来实现关键的健康成果。 抗击美国南部，特别是德克萨斯州的艾滋病毒流行，为结束美国艾滋病毒做出贡献 流行病并学习如何在美国资源有限的地区最好地做到这一点，因此我们将建立。 德克萨斯州艾滋病研究发展中心 (D-CFAR)，支持国家的总体使命 CFAR 计划通过促进高度优先的艾滋病毒研究并支持结束艾滋病毒流行的努力 美国三个机构合作提出了这个 D-CFAR：休斯敦贝勒医学院， 德克萨斯大学休斯顿健康科学中心和德克萨斯生物医学研究所 圣安东尼奥市。凭借其调查人员的杰出专业知识，德克萨斯州 D-CFAR 将重点关注其调查结果。 五年资助期内关于“终止艾滋病毒和优化艾滋病毒健康”研究主题的活动 为了实现其目标，德克萨斯州 D-CFAR 将： 1) 提供组织和财务管理 促进加强和丰富 D-CFAR 研究和知识的活动和计划 2）支持有针对性的高优先级跨学科试点研究项目，协助应对 新的艾滋病毒相关研究举措，并促进关于终止艾滋病毒和改善艾滋病毒感染者健康的研究 德克萨斯州；3) 提供最先进的专业知识、建议和服务，以促进艾滋病毒相关领域的发展 D-CFAR 调查员的研究 德克萨斯州 D-CFAR 将支持行政核心、发展核心。 核心、基础科学核心以及临床和生物统计学核心，以满足研究者的需求并促进 科学核心将建立在病毒学、非人类灵长类动物方面的突出优势。 D-CFAR 将聘请社区咨询委员会和 加上内部和外部顾问委员会的指导，D- CFAR 将促进基础、转化、临床、卫生服务和 D-CFAR 将极大地增进消除艾滋病毒和改善艾滋病毒所需的知识。 德克萨斯州和类似地区的 PWH 的健康，培训下一代科学家，并成长为一个全面的 CFAR，从而有助于结束德克萨斯州、美国南部及其他地区的艾滋病毒流行。