Texas Developmental Center for AIDS Research

德克萨斯艾滋病研究发展中心

• 批准号: 10397168
• 负责人: Thomas P Giordano
• 金额: $ 262.88万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-23 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10397168
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Americas; Area; Award; Basic Science; Biomedical Research; Biometry; Biostatistics Core; California; Caring; Censuses; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Trials; Collaborations; Communication; Communities; Community Outreach; Coupled; Data; Development; Diagnosis; Environment; Epidemic; Event; Fostering; Funding; Funding Opportunities; Geographic state; Goals; HIV; HIV Infections; HIV diagnosis; Health; Health Insurance; Health Sciences; Health Services; Home; Human Resources; Institution; Knowledge; Leadership; Learning; Medicaid; Medicine; Mentors; Mission; Newly Diagnosed; Occupational activity of managing finances; Outcome; Persons; Pilot Projects; Policies; Population; Prevention; Procedures; Process; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Research Priority; Research Project Grants; Research Support; Resource-limited setting; Resources; Risk; Scientist; Services; South Texas; Strategic Planning; Supervision; Texas; Training; Treatment outcome; United States; United States National Institutes of Health; Universities; Viral; base; career; college; combat; federal policy; improved; innovation; member; multidisciplinary; next generation; nonhuman primate; novel coronavirus; pandemic coronavirus; prevent; programs; substance use; symposium; synergism; transmission process; virology; working group

PROJECT SUMMARY – TEXAS DEVELOPMENTAL CENTER FOR AIDS RESEARCH In 2019, the US announced a plan to End the HIV Epidemic by 2030. To be successful, strategies that improve HIV prevention and HIV treatment outcomes are needed. Only 56% of people with HIV (PWH) were virally suppressed in 2018, a critical determinant of health outcomes and transmission risk, and 51% of HIV diagnoses in 2018 were in the US South, despite constituting only 38% of the population in the US. Texas is the second most populous state in the US, behind California, with about 29 million residents, and is in the US South as defined by CDC and the Census Bureau. Unfortunately, this large Texas population, coupled with weaker public health and prevention policies and funding across the US South, has a growing HIV population that lags in critical health outcomes. There is an urgent need for more research and research infrastructure to combat the HIV epidemic in the US South and specifically in Texas to both contribute to ending the US HIV epidemic and to learn how to best do that in resource constrained areas of the US. We therefore will establish a Texas Developmental Center for AIDS Research (D-CFAR) to support the overall mission of the national CFAR program by facilitating high-priority HIV research and supporting the effort to end the HIV epidemic in the US. Three institutions have collaborated to propose this D-CFAR: Baylor College of Medicine in Houston, The University of Texas Health Science Center at Houston and the Texas Biomedical Research Institute in San Antonio. Based upon the outstanding expertise of its investigators, the Texas D-CFAR will focus its activities in the five-year funding period on the research theme “Ending HIV and Optimizing HIV Health in Texas.” To accomplish its goals, the Texas D-CFAR will: 1) Provide organizational and financial management and facilitate activities and programs that strengthen and enrich the D-CFAR research and intellectual environment; 2) Support targeted high-priority interdisciplinary pilot research projects, assist in responding to new HIV-related research initiatives, and facilitate research on ending HIV and improving health of PWH in Texas; and 3) Provide state-of-the-art expertise, advice, and services to facilitate the range of HIV-related research for D-CFAR investigators. The Texas D-CFAR will support an Administrative Core, a Developmental Core, a Basic Science Core and a Clinical and Biostatistics Core to meet investigator needs and catalyze innovative research. The scientific Cores will build on outstanding strengths in virology, non-human primate resources, clinical trials research and biostatistics. The D-CFAR will engage a Community Advisory Board and Internal and External Advisory Boards for guidance. Coupled with outstanding institutional support, the D- CFAR will stimulate new research and collaborations among basic, translational, clinical, health services and public health researchers. The D-CFAR will significantly advance knowledge needed to end HIV and improve the health of PWH in Texas and similar areas, train the next generation of scientists, and grow into a full CFAR, thereby contributing to ending the HIV epidemic in Texas, the US South, and beyond.

项目摘要 - 德克萨斯州艾滋病发展中心 2019年，美国宣布了一项计划，计划到2030年结束艾滋病毒的流行。为了取得成功，可以改善的策略 需要预防HIV和HIV治疗结果。实际上，只有56％的艾滋病毒（PWH）是 在2018年被抑制，是健康结果和传播风险的关键决定者，艾滋病毒的51％ 2018年的诊断是在美国南部，目的地仅占美国人口的38％。得克萨斯州是 美国第二大人口众多的州，仅次于加利福尼亚州，约有2900万居民，在美国 疾病预防控制中心和人口普查局定义的南部。不幸的是，得克萨斯州的大量人口以及 整个美国南部的公共卫生和预防政策和资金较弱，艾滋病毒人口不断增长 这落在了关键的健康状况中。迫切需要更多的研究和研究基础设施才能 打击美国南部的艾滋病毒流行病，尤其是在德克萨斯州的艾滋病毒，以终止美国艾滋病毒 流行病，学习如何在美国的资源约束领域中最好地做到这一点。因此，我们将建立 德克萨斯州艾滋病研究中心（D-CFAR）支持国家的整体任务 CFAR计划通过促进高优先性HIV研究并支持结束HIV流行的努力 美国。三个机构合作提出了此D-CFAR：休斯顿休斯顿的贝勒医学院 德克萨斯大学健康科学中心和德克萨斯州生物医学研究所 圣安东尼奥。根据调查人员的杰出专业知识，德克萨斯州D-CFAR将集中精力 研究主题的五年资助期间的活动“结束艾滋病毒并优化艾滋病毒健康 德克萨斯州。“为实现其目标，德克萨斯州D-CFAR将：1）提供组织和财务管理 并促进加强和丰富D-CFAR研究和智力的活动和计划 环境; 2）支持有针对性的高优先级跨学科的试点研究项目，协助回应 新的与HIV相关的研究计划，并促进有关终止艾滋病毒和改善PWH健康状况的研究 德克萨斯州； 3）提供最先进的专业知识，建议和服务，以促进与HIV相关的范围 D-CFAR研究人员的研究。德克萨斯州D-CFAR将支持行政核心，这是一种发展 核心，基础科学核心以及临床和生物统计学核心，以满足研究者的需求并催化 创新研究。科学核心将基于病毒学，非人类灵长类动物的出色优势 资源，临床试验研究和生物统计学。 D-CFAR将与社区顾问委员会和 内部和外部咨询委员会指导。再加上出色的机构支持，D- CFAR将刺激基本，翻译，临床，卫生服务的新研究和合作 公共卫生研究人员。 D-CFAR将大大促进结束艾滋病毒和改善所需的知识 德克萨斯州和类似地区的PWH的健康状况，培训下一代科学家，并成长为一个完整的 CFAR，从而终止德克萨斯州，美国南部及其他地区的艾滋病毒流行。