Postdoctoral Training for Translating Research in Regenerative Medicine

再生医学研究转化博士后培训

• 批准号: 10263913
• 负责人: Kibum Lee
• 金额: $ 17.79万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263913
• 关键词: Regenerative Medicine; Research; Translating; post-doctoral training

Project Summary/Abstract The current NIBIB T32 postdoctoral training program, "Training Without Borders: Translational Research in Regenerative Medicine" (2012-2017), has focused on two innovative features: (1) the concept of a geographically dispersed training faculty to harness a unique team of mentors; and (2) a combination of conventional academic training (state-of-the-art science, proposal writing, responsible conduct of research) together with training in translation and commercialization. This has resulted in a geographically dispersed "community of learning". The core strength of this program has been its interdisciplinary breadth, providing trainees with opportunities to conduct research on rationally designed biomaterials, bioactive microenvironments, cell profiling technologies, and regenerative biology. Based on this success the proposed training program (2018-2023) will retain the current structure, revise the mentor-institution network, and use a new paradigm - Bench-to-Business-to-Bedside (B3). While the term Bench-to-Bedside is often used to describe translation, we believe that the B3 model offers more relevant training in translation by providing trainees with mentoring constellations consisting of academic, industrial, and clinical subject matter experts. In addition to focusing on state-of-the-art science, postdoctoral training programs must improve the chances of their trainees finding employment across all sectors: academia, industry, and alternative career paths, in order to ultimately achieve clinical therapies. We have coined the term "innovation-primed science" to represent a range of breakthrough, innovation- generating scientific ideas that will offer our trainees a range of scientific projects to work on, from pioneering basic science to commercialization-ready projects, for which proof-of-concept has already been established. We will create a unique training infrastructure that is made up not only of the traditional academic mentors (scientific or clinical faculty who lead top laboratories), but also of a Translation Advisory Board (TAB) comprising experts in regenerative medicine and clinical practice, entrepreneurs, industrial scientists, investors, and leading subject-matter experts in translation and commercialization. The TAB will effectively fill the expertise gap among our academic faculty mentors, by completing a mentoring constellation of academic, industrial, and clinical experts for each trainee. A rich didactic program will combine both established approaches and new concepts to deliver a balance of experience to trainees while optimizing the expertise of 14 core mentors and 16 clinical, industrial and entrepreneurial advisors. Specific program elements are Individualized B3 Mentoring Constellations, Face-to- Face Interactions and Workshops, Online Interactions and Seminar Series, Defined and Monitored Integration of Didactic Elements during the Fellowship Term, Mentoring of Trainees and Professional Development, and Supporting Junior Mentors.

项目概要/摘要 目前NIBIB T32博士后培养项目“Training Without Borders: Translational Research in 再生医学》（2012-2017）重点关注两个创新特点：（1）再生医学的概念 地理上分散的培训师资，以利用独特的导师团队； (2) 的组合 常规学术培训（最先进的科学、提案撰写、负责任的研究行为） 以及翻译和商业化方面的培训。这导致了地理上的分散 “学习社区”。该计划的核心优势在于其跨学科广度，提供 学员有机会对合理设计的生物材料、生物活性进行研究 微环境、细胞分析技术和再生生物学。 基于这一成功，拟议的培训计划（2018-2023）将保留当前结构，并修改 导师-机构网络，并使用新的范例 - 实验室到企业到床边 (B3)。虽然该术语 Bench-to-Bedside 通常用于描述翻译，我们认为 B3 模型提供了更多相关性 通过为学员提供由学术、工业和领域组成的指导群来进行翻译培训 临床主题专家。除了关注最先进的科学外，博士后培训 计划必须提高学员在所有部门找到就业的机会：学术界、 行业和替代职业道路，以最终实现临床治疗。 我们创造了“创新驱动的科学”这个术语来代表一系列突破、创新—— 产生科学想法，为我们的学员提供一系列可以从事的科学项目，从开创性的 基础科学到商业化项目，其概念验证已经建立。 我们将创建一个独特的培训基础设施，不仅由传统的学术导师组成 （领导顶级实验室的科学或临床教师），还有翻译顾问委员会 (TAB) 由再生医学和临床实践专家、企业家、工业科学家、 投资者以及翻译和商业化领域的领先主题专家。 TAB 将有效填补 通过完成学术指导星座，我们的学术教师导师之间的专业知识差距， 每位学员的工业和临床专家。 丰富的教学计划将结合既定方法和新概念，以实现平衡 培训学员的经验，同时优化 14 名核心导师和 16 名临床、工业和 创业顾问。具体计划内容包括个性化 B3 辅导星座、面对面辅导 人脸交互和研讨会、在线交互和研讨会系列、定义和监控的集成 奖学金期间的教学要素、受训者指导和专业发展，以及 支持青年导师。