Postdoctoral Training for Translating Research in Regenerative Medicine

再生医学研究转化博士后培训

• 批准号: 10263913
• 负责人: Kibum Lee
• 金额: $ 17.79万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263913
• 关键词: Regenerative Medicine; Research; Translating; post-doctoral training; Regenerative Medicine; Research; Translating; post-doctoral training

Project Summary/Abstract The current NIBIB T32 postdoctoral training program, "Training Without Borders: Translational Research in Regenerative Medicine" (2012-2017), has focused on two innovative features: (1) the concept of a geographically dispersed training faculty to harness a unique team of mentors; and (2) a combination of conventional academic training (state-of-the-art science, proposal writing, responsible conduct of research) together with training in translation and commercialization. This has resulted in a geographically dispersed "community of learning". The core strength of this program has been its interdisciplinary breadth, providing trainees with opportunities to conduct research on rationally designed biomaterials, bioactive microenvironments, cell profiling technologies, and regenerative biology. Based on this success the proposed training program (2018-2023) will retain the current structure, revise the mentor-institution network, and use a new paradigm - Bench-to-Business-to-Bedside (B3). While the term Bench-to-Bedside is often used to describe translation, we believe that the B3 model offers more relevant training in translation by providing trainees with mentoring constellations consisting of academic, industrial, and clinical subject matter experts. In addition to focusing on state-of-the-art science, postdoctoral training programs must improve the chances of their trainees finding employment across all sectors: academia, industry, and alternative career paths, in order to ultimately achieve clinical therapies. We have coined the term "innovation-primed science" to represent a range of breakthrough, innovation- generating scientific ideas that will offer our trainees a range of scientific projects to work on, from pioneering basic science to commercialization-ready projects, for which proof-of-concept has already been established. We will create a unique training infrastructure that is made up not only of the traditional academic mentors (scientific or clinical faculty who lead top laboratories), but also of a Translation Advisory Board (TAB) comprising experts in regenerative medicine and clinical practice, entrepreneurs, industrial scientists, investors, and leading subject-matter experts in translation and commercialization. The TAB will effectively fill the expertise gap among our academic faculty mentors, by completing a mentoring constellation of academic, industrial, and clinical experts for each trainee. A rich didactic program will combine both established approaches and new concepts to deliver a balance of experience to trainees while optimizing the expertise of 14 core mentors and 16 clinical, industrial and entrepreneurial advisors. Specific program elements are Individualized B3 Mentoring Constellations, Face-to- Face Interactions and Workshops, Online Interactions and Seminar Series, Defined and Monitored Integration of Didactic Elements during the Fellowship Term, Mentoring of Trainees and Professional Development, and Supporting Junior Mentors.

项目摘要/摘要 当前的Nibib T32博士后培训计划：“无国界的培训：转化研究 再生医学”（2012-2017），重点介绍了两个创新特征：（1） 地理分散的培训教师，以利用独特的导师团队； （2）组合 常规学术培训（最先进的科学，提案写作，负责任的研究行为） 以及翻译和商业化的培训。这导致了地理上分散的 “学习社区”。该计划的核心优势是其跨学科的广度，提供 学员有机会对合理设计的生物材料，生物活性进行研究 微环境，细胞分析技术和再生生物学。 基于这一成功，拟议的培训计划（2018-2023）将保留当前的结构，修改 指导机构网络，并使用新的范式 - 替补阶层（B3）。而术语 台式卧式通常用于描述翻译，我们认为B3模型提供了更相关的 通过为学员提供由学术，工业和 临床主题专家。除了专注于最先进的科学，博士后培训 计划必须提高学员的机会，从而在所有领域找到就业：学术界， 行业和替代职业道路，以最终实现临床疗法。 我们创造了“创新的科学”一词，以代表一系列突破性，创新 - 产生科学思想，将为我们的学员提供一系列科学项目，从开创性 已经建立了有关商业化项目的基础科学，已建立了概念验证。 我们将创建一个独特的培训基础设施，不仅由传统的学术导师组成 （领导顶级实验室的科学或临床教师），但也是翻译咨询委员会（TAB） 包括再生医学和临床实践专家，企业家，工业科学家， 投资者以及领先的翻译和商业化专家。标签将有效地填充 我们的学术教师导师之间的专业知识差距是通过完成学术的指导星座的 每个学员的工业和临床专家。 丰富的教学计划将结合既定方法和新概念，以实现平衡 在优化14位核心导师和16位临床，工业和 企业家顾问。特定的程序要素是个性化的B3指导星座，面对面 面对互动和讲习班，在线互动和研讨会系列，定义和监视集成 奖学金期间的教学要素，指导学员和专业发展以及 支持初级导师。