Pilot Projects Program

试点项目计划

• 批准号: 10630392
• 负责人: Patrycja Marta Dubielecka-Szczerba
• 金额: $ 19.68万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630392
• 关键词: Acceleration; Aging; Award; Basic Science; Biological Sciences; Biology of Aging; Cancer Center; Caring; Centers of Research Excellence; Clinic; Clinical; Clinical Data; Clinical Trials; Collaborations; Communities; Core Facility; Data Analyses; Development; Disease; Early identification; Education; Ensure; Evaluation; Event; Extramural Activities; Feasibility Studies; Flow Cytometry; Fostering; Funding; Funding Mechanisms; Goals; Grant; Healthcare; Hospitals; Infrastructure; Institution; Longevity; Measures; Mentors; Mentorship; Methodology; New England; Outcome; Outcome Measure; Phase; Pilot Projects; Play; Population; Prevention strategy; Program Reviews; Regenerative Medicine; Reproducibility; Request for Proposals; Research; Research Personnel; Resources; Rhode Island; Role; Science; Scientist; Secure; Services; Strategic Planning; Structure; Technology; Time; Tissues; Training; Translating; Translations; Underrepresented Populations; Underrepresented Students; United States National Institutes of Health; Universities; Vision; Wages; Work; age related; biobank; clinical practice; design; extracellular vesicles; graduate student; instrumentation; inter-institutional; medical schools; member; multidisciplinary; primary outcome; professor; programs; recruit; service programs; stem cells; success; synergism; translational approach; translational impact; translational potential; translational scientist; undergraduate student; voucher; Acceleration; Aging; Award; Basic Science; Biological Sciences; Biology of Aging; Cancer Center; Caring; Centers of Research Excellence; Clinic; Clinical; Clinical Data; Clinical Trials; Collaborations; Communities; Core Facility; Data Analyses; Development; Disease; Early identification; Education; Ensure; Evaluation; Event; Extramural Activities; Feasibility Studies; Flow Cytometry; Fostering; Funding; Funding Mechanisms; Goals; Grant; Healthcare; Hospitals; Infrastructure; Institution; Longevity; Measures; Mentors; Mentorship; Methodology; New England; Outcome; Outcome Measure; Phase; Pilot Projects; Play; Population; Prevention strategy; Program Reviews; Regenerative Medicine; Reproducibility; Request for Proposals; Research; Research Personnel; Resources; Rhode Island; Role; Science; Scientist; Secure; Services; Strategic Planning; Structure; Technology; Time; Tissues; Training; Translating; Translations; Underrepresented Populations; Underrepresented Students; United States National Institutes of Health; Universities; Vision; Wages; Work; age related; biobank; clinical practice; design; extracellular vesicles; graduate student; instrumentation; inter-institutional; medical schools; member; multidisciplinary; primary outcome; professor; programs; recruit; service programs; stem cells; success; synergism; translational approach; translational impact; translational potential; translational scientist; undergraduate student; voucher

PROGRAM SUMMARY/ABSTRACT - STEM CELL AND AGING COBRE PILOT GRANT PROGRAM Building on the success of our Phase 1 and 2 COBRE program, we propose the Stem Cells and Aging (SCA) COBRE Pilot Grants Program with an objective to recruit promising teams of early-stage investigators by providing a funding mechanism for pilot projects and provide intellectual, technical and instrumental infrastructure. In Specific Aim 1, we will select teams of translational researchers (consisting of basic and clinical scientists, with at least one early-stage investigator) for 3 pilot project awards ($50,000 per year for 2 years and minimum of 6 awards for the duration of the program), with additional summer stipends for students from under- represented groups to enhance diversity. The request for proposals will focus on projects with high potential of translating basic research into clinical practice. In Specific Aim 2, we will provide structured, formal mentorship (provided by senior, extramurally-funded investigators) for participating early-stage basic- and clinician-scientist investigators focused on stem cell and aging research, regenerative medicine and age-related diseases to facilitate their transition to research independence with extramural funding. In Specific Aim 3, we will promote the utilization and sustainability of the SCA COBRE Core Facilities (developed in Phases 1 and 2, and including Flow Cytometry, Extracellular Vesicles, Lentiviral Construct Core Facilities) through their utilization in the pilot projects as well as through vouchers to affiliated scientists participating in the program. In the Specific Aim 4, we will provide post-award mentorship, advisory and grantsmanship services for program awardees, and synergize efforts to transform funded projects into competitive applications at the R01 or equivalent level. Emphasis will be placed on rigorous, reproducible science with analysis supported by expert biostatisticians guiding the participating researchers. The core of the program will rely on the work of the SCA Pilot Grants Program Steering Committee who will provide mentoring and oversight and engage (for identification of early-stage investigators, for review of the pilot awards, and expert mentorship) the community of researchers across the multi-institutional consortium encompassing Brow University (Center of the Biology of Aging, Brown and Lifespan Cancer Centers), the Warren Alpert Medical School, the clinical experts from the Lifespan healthcare/Rhode Island Hospital and from Care new England. By establishing a multidisciplinary scientific infrastructure providing access to state-of- the-art instrumentation and technologies, as well as rigorous mentorship, advising, review and outcome guidance, the Phase 3 SCA COBRE Pilot Grant Program will contribute to expansion and transformation the biomedical and educational landscape within Rhode Island, creating a premier national center for research on stem cell, aging, and regenerative medicine. We will evaluate the program using outcome measures that include number and quality of submissions (measured by review scores), mentor and investigator evaluations and diversity of applicants and success in securing extramural awards.

程序摘要/摘要 - 干细胞和老化的毛病试点赠款计划 在我们的第1阶段和第2索贝尔计划的成功之下，我们提出了干细胞和衰老（SCA） COBRE飞行员赠款计划的目标是招募有前途的早期调查人员团队 为试点项目提供资金机制，并提供智力，技术和工具 基础设施。在特定目标1中，我们将选择翻译研究人员团队（由基本和临床组成 科学家，至少有一名早期调查员）获得了3个试点项目奖项（每年$ 50,000，持续2年， 该计划的持续时间至少获得6个奖项），并为来自底层的学生提供额外的夏季津贴 代表群体以增强多样性。提案请求将集中于具有很高潜力的项目 将基础研究转化为临床实践。在特定目标2中，我们将提供结构化的正式指导 （由高级，外部资助的研究人员提供）参加早期基础和临床医生 - 科学家 研究人员专注于干细胞和衰老研究，再生医学和与年龄有关的疾病 通过校外资金促进他们向研究独立的过渡。在特定目标3中，我们将促进 SCA COBRE核心设施的利用和可持续性（以第1和2阶段开发，包括 流式细胞仪，细胞外囊泡，慢病毒构建核心设施）通过飞行员的利用 项目以及通过凭证，参与该计划的科学家。在特定目标4中，我们 将为获奖者提供授予后的指导，咨询和赠款服务，并协同作用 在R01或同等水平上将资助项目转变为竞争应用程序的努力。重点将是 由专家生物统计学家指导的分析进行分析的严格，可重复的科学 参与研究人员。该计划的核心将依靠SCA飞行员赠款计划转向的工作 将提供指导和监督和参与的委员会（用于确定早期调查人员， 为了审查飞行员奖和专家指导）多机构的研究人员社区 财团涵盖眉毛大学（衰老，棕色和寿命癌中心的生物学中心）， 沃伦·阿尔珀特医学院 来自新英格兰护理。通过建立一个多学科的科学基础设施，可访问 艺术仪器和技术，以及严格的指导，建议，审查和结果 指导，第三阶段SCA索贝尔飞行员赠款计划将有助于扩展和转型 罗德岛州内的生物医学和教育景观，创建了一个主要国家研究中心 干细胞，衰老和再生医学。我们将使用包括 提交的数量和质量（通过审查分数衡量），导师和研究者评估以及 申请人的多样性和成功获得壁外奖项的成功。