Neuropathology Core

神经病理学核心

基本信息

批准号：
10264664
负责人：
LEE-WAY JIN
金额：
$ 32.71万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10264664
关键词：
African American Aging Alzheimer&apos s Disease Animal Model Applications Grants Asians Autopsy Basic Science Biological Biological Markers Brain Brain Diseases Brain Injuries Brain imaging Clinic Clinical Clinical Pathology Cognitive Collaborations Complex Consensus Data Data Set Dementia Detection Diagnosis Diagnostic Disease Education Education and Outreach Educational Activities Elderly Faculty Fostering Funding Future General Population Goals Gold Grant Heterogeneity Hispanics Image Impaired cognition Individual Infrastructure Injury Interdisciplinary Study Intervention Journals Knowledge Latino Leadership Link Longitudinal cohort Machine Learning Medical Staff Methods Minority Mission Modernization Molecular Participant Pathogenesis Pathologic Pathology Pathway interactions Phenotype Play Predictive Value Prevention Process Prognosis Publications Reporting Research Research Infrastructure Research Personnel Research Project Grants Resources Risk Factors Role Sampling Scientist Services Societies Specimen Standardization Students Study Subject System Techniques Technology Time Tissue Banks Tissue Sample Tissues Training Translating Translational Research aging brain biobank biological heterogeneity brain tissue career cerebrovascular clinical heterogeneity cognitive ability cognitive testing cohort dementia risk digital pathology experience meetings member multi-ethnic neuropathology novel racial and ethnic symposium tool

项目摘要

PROJECT SUMMARY/ABSTRACT - Neuropathology Core The overarching goal of the UCD ADRC is to understand the multiple and complex determinants that explain the heterogeneity of cognitive trajectories among diverse older adults. To help achieve this goal, the primary mission of the Neuropathology Core (NPC) is to assess and quantify brain injury in the form of multiple pathologies essential to the most precise and relevant characterization of individual cognitive ability. To provide even deeper pathological phenotypes, the NPC has leveraged and enhanced Core infrastructure by implementing digital pathology and developing machine learning workflows for quantitative regional analysis. These NPC data, when linked with comprehensive cognitive assessment, brain imaging, and other biological markers generated by other ADRC Cores will facilitate new understandings into the protective/risk factors of brain aging and dementia processes. Our NPC is unique in (1) its study subjects have been drawn from a diverse multi-ethnic/racial longitudinal cohort maintained by the Clinical Core (CC) with an emphasis on early disease/early pathology, (2) its collection of tissue samples from cases whose cognitive trajectories have been modified by clinically, imaging proven, and pathologically confirmed cerebrovascular injury and (3) its sizeable number of samples and datasets from minority participants (39 Hispanic/Latino, 18 Asian, and 52 African American) that have resulted in high impact publications. In collaboration with the other ADRC Cores, we have built, maintained, and enhanced our research infrastructure, accumulating unique datasets, high quality samples, and experience in clinic-pathological, translational, and basic research collaborations. New causes and contributing factors of dementia continue to be discovered by studies using post-mortem brain specimens, enriching the pool of biomarkers for risk of dementia. Modern neuropathology techniques (e.g., our machine learning studies) combined with new molecular tools (such as our Quanterix system within the Biomarker core) have the potential to tremendously advance our understanding of disease pathogenesis, thus providing a degree of precision to anchor the clinical and biological heterogeneity commonly observed in dementia. Moreover, neuropathology plays a central role in future interventions, as postmortem diagnosis is the gold standard to establish biomarkers applicability and the efficacy of experimental interventions. Thus, we envision the NPC will continue to be a central player in multi-component research projects in the effort to find new avenues for dementia treatment. As such, the NPC leadership will continue networking with researchers to conduct multidisciplinary research while upgrading the core diagnostic capabilities to enable detection of diverse brain injury pathways using novel methods.

项目摘要/摘要 - 神经病理学核心 UCD ADRC 的首要目标是了解解释多个复杂的决定因素不同老年人之间认知轨迹的异质性。为了帮助实现这一目标，主要神经病理学核心 (NPC) 的使命是评估和量化多种形式的脑损伤对于最精确和相关的个体认知能力表征至关重要的病理学。提供为了更深入的病理表型，NPC 通过以下方式利用和增强了核心基础设施：实施数字病理学并开发用于定量区域分析的机器学习工作流程。这些 NPC 数据与综合认知评估、脑成像和其他生物学相关其他 ADRC 核心生成的标记将促进对以下疾病的保护/风险因素的新理解：大脑老化和痴呆过程。我们的全国人大的独特之处在于（1）它的研究对象是从由临床核心 (CC) 维护的多样化多民族/种族纵向队列，重点是早期疾病/早期病理学，（2）从认知轨迹发生变化的病例中收集组织样本经过临床、影像学证实和病理证实的脑血管损伤进行了修改；(3) 来自少数族裔参与者的大量样本和数据集（39 名西班牙裔/拉丁裔、18 名亚洲裔和 52 名非裔美国人）发表了具有高影响力的出版物。与其他 ADRC 合作核心，我们建立、维护和增强了我们的研究基础设施，积累了独特的数据集，高质量的样本以及临床病理、转化和基础研究合作的经验。尸检研究不断发现痴呆症的新原因和影响因素大脑样本，丰富了痴呆症风险的生物标志物库。现代神经病理学技术（例如，我们的机器学习研究）与新的分子工具（例如我们的 Quanterix 系统）相结合生物标志物核心）有潜力极大地增进我们对疾病发病机制的理解，从而提供一定程度的精确度来锚定通常观察到的临床和生物异质性失智。此外，神经病理学在未来的干预措施中发挥着核心作用，因为尸检诊断是建立生物标志物适用性和实验干预效果的黄金标准。因此，我们设想 NPC 将继续成为多组成部分研究项目的核心参与者，努力寻找痴呆症治疗的新途径。因此，全国人大领导层将继续与研究人员建立联系进行多学科研究，同时升级核心诊断能力，以实现检测使用新方法研究不同的脑损伤途径。