Clinical Core

临床核心

• 批准号: 10264431
• 负责人: LIANA G APOSTOLOVA
• 金额: $ 74.62万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264431
• 关键词: Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Autopsy; Bioinformatics; Biological Markers; Blood; Brain; Clinical; Cognition; Cognitive; Cognitive aging; Collaborations; Communities; DNA; Data; Data Set; Dementia; Early Diagnosis; Enrollment; Environment; Familial Dementias; Family; Family member; Fostering; Frontotemporal Dementia; Funding; Genetic Markers; Goals; Grant; Healthcare; Indiana; Individual; Industry; Infrastructure; Inherited; Interdisciplinary Study; International; Investigational Drugs; Late Onset Alzheimer Disease; Mission; Neurodegenerative Disorders; Neuropsychology; Paper; Participant; Patients; Peer Review; Peripheral Blood Mononuclear Cell; Pilot Projects; Plasma; Play; Presenile Alzheimer Dementia; RNA; Research; Research Infrastructure; Research Personnel; Research Subjects; Resource Sharing; Resources; Role; Sampling; Science; Specimen; Standardization; Systems Biology; Training and Education; Translations; United States National Institutes of Health; Work; base; case control; clinical examination; cohort; data management; data sharing; education research; follow-up; imaging biomarker; improved; innovation; interest; multidisciplinary; multiple omics; neuroimaging; neuropathology; nonalzheimer dementia; outreach; peripheral blood; pre-clinical; prodromal Alzheimer' s disease; programs; recruit; research study; statistics; training opportunity

Project Summary – Clinical Core (CC) The Clinical Core (CC) is critical to the function of the Indiana Alzheimer’s Disease Research Center (IADRC). A major emphasis is to identify and clinically characterize patients with preclinical and early symptomatic stages of AD, including early and late onset AD, as well as asymptomatic, early symptomatic, and affected individuals from families with hereditary AD, genetically distinct non-AD dementia, and the presently enrolled sporadic frontotemporal dementia cases. The CC will support NACC, NCRAD and other local, regional, national and international projects by obtaining and facilitating the banking and storage of neuroimaging data as well as blood, DNA, peripheral blood RNA, plasma, serum, CSF, peripheral blood mononuclear cells (PBMC) and postmortem brain samples from our research participants for further characterization by the Neuroimaging Core (NIC), Genetics, Biomarker, and Biospecimen Core (GBBC), Neuropathology Core (NPC) and the Data Management and Statistical Cores (DC). Patients from the CC will be offered as appropriate participation in ADNI, DIAN, LOAD, investigational drug trials and other local and multicenter research studies. In addition, we will collaborate with the Research Education Component (REC) and the Outreach, Recruitment, and Engagement (OREC) Core to provide education and training opportunities to researchers and trainees at all levels and to educate and support affected participants, family members, and the community at large.

项目摘要 – 临床核心 (CC) 临床核心 (CC) 对于印第安纳阿尔茨海默病研究中心 (IADRC) 的运作至关重要。 主要重点是识别和临床表征处于临床前和早期症状阶段的患者 AD 的患者，包括早发型和晚发型 AD，以及无症状、早期症状和受影响的个体 来自患有遗传性 AD、遗传上不同的非 AD 痴呆症以及目前入组的散发性痴呆症的家庭 CC 将支持 NACC、NCRAD 和其他地方、区域、国家和地区的额颞叶痴呆病例。 通过获取和促进神经影像数据以及血液的银行和存储来开展国际项目， DNA、外周血 RNA、血浆、血清、CSF、外周血单核细胞 (PBMC) 和尸检 我们的研究参与者的大脑样本，供神经影像核心 (NIC) 进一步表征， 遗传学、生物标志物和生物样本核心 (GBBC)、神经病理学核心 (NPC) 和数据管理 来自 CC 的患者将酌情参与 ADNI、DIAN、 此外，我们还将合作进行 LOAD、研究性药物试验以及其他本地和多中心研究。 包括研究教育部分 (REC) 和外展、招聘和参与 (OREC) 核心 为各级研究人员和学员提供教育和培训机会，并进行教育和培训 支持受影响的参与者、家庭成员和整个社区。