Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's Disease

利用神经影像生物标志物了解社交网络在阿尔茨海默病中的作用

• 批准号: 10426092
• 负责人: LIANA G APOSTOLOVA
• 金额: $ 67.6万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426092
• 关键词: Address; Adult; Age; Age-associated memory impairment; Aging; Alzheimer disease prevention; Alzheimer' s Disease; American; Area; Attention; Behavioral; Behavioral Mechanisms; Biological; Biological Markers; Biological Process; Biosocial; Caregivers; Characteristics; Clinical; Cognitive; Data; Data Set; Dementia; Dependence; Development; Diagnosis; Early Diagnosis; Economic Burden; Elderly; Emotional; Etiology; Exposure to; Family; Family health status; Frequencies; Funding; Goals; Health; Health Care Costs; Healthcare Systems; Home; Impaired cognition; Indiana; Individual; Intervention; Interview; Lead; Life; Linear Regressions; Link; Literature; Longevity; Measures; Mediating; Mediation; Memory; Methods; Modeling; Nerve Degeneration; Neurobehavioral Manifestations; Neurology; Pathway interactions; Pattern; Phenotype; Prevalence; Process; Property; Proxy; Research; Resources; Role; Sampling; Science; Social Behavior; Social Environment; Social Interaction; Social Network; Social Processes; Social Protection; Stimulus; Structure; Symptoms; Testing; Thick; United States National Institutes of Health; aged; care coordination; cognitive testing; cohort; constriction; dementia risk; density; disability; family burden; gray matter; improved; insight; mild cognitive impairment; neuroimaging; neuroimaging marker; neuropathology; novel; pre-clinical; prevent; ranpirnase; resilience; response; social; social contact; social engagement; tool

PROJECT SUMMARY The goal of the proposed project is to understand the role of personal social network dynamics in the etiology and clinical progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). We propose to characterize social-behavioral and biological mechanisms underlying relationships between social networks and aging-related neuropathology. AD and dementia takes a devastating toll on individuals, families, and the health care system. A critical point of intervention in AD is the social environment, which has the potential to moderate underlying neuropathology, altering the typical cognitive course of dementia. Positive social interaction – including number of confidants, frequency of social contact, support, and social engagement – is associated with reduced risk for dementia and a slower trajectory of cognitive decline among diagnosed individuals. However, the existing literature relies on limited and unidimensional measures of social interaction, and has yet to consider the role of underlying biological neurodegeneration, which manifests long before observable clinical cognitive symptoms of dementia. The proposed project addresses these gaps via three specific aims: Aim 1 is to identify baseline associations between social network characteristics and neurodegeneration (QNPs). Aim 2 is to examine longitudinal relationships between personal social network dynamics and neurodegenerative changes. Aim 3 is to evaluate alternative models of the coevolution of personal social networks and neurodegenerative changes in trajectories of clinical cognitive decline. The proposed study is interdisciplinary, combining leading-edge methods from the social and biomedical sciences, and leveraging the resources of funded centers for AD, neuroimaging, and network science. By increasing our understanding of the links between biological and social processes, this project may help identify novel targets for intervention to reduce the burden of AD on individuals, families, and the health care system.

项目概要 该项目的目标是了解个人社交网络动态在 轻度认知障碍（MCI）和阿尔茨海默病的病因和临床进展 （AD）。我们建议描述潜在的社会行为和生物机制。 社交网络与衰老相关的神经病理学和痴呆症之间的关系。 对个人、家庭和医疗保健系统造成毁灭性的损失。 对 AD 的干预是社会环境，它有可能调节潜在的 神经病理学，改变痴呆症的典型认知过程——积极的社会互动。 包括知己的数量、社交接触的频率、支持和社交参与——是 与痴呆症风险降低和认知能力下降轨迹减缓相关 然而，现有文献依赖于有限且单一的维度。 社会互动的衡量标准，尚未考虑潜在的生物因素的作用 神经退行性变，早在可观察到的临床认知症状之前就表现出来 拟议的项目通过三个具体目标来解决这些差距： 目标 1 是确定 社交网络特征与神经退行性变（QNP）之间的基线关联。 目标 2 是检验个人社交网络动态与 目标 3 是评估个人协同进化的替代模型。 社交网络和临床认知衰退轨迹中的神经退行性变化。 拟议的研究是跨学科的，结合了社会和社会的前沿方法 生物医学科学，并利用受资助的 AD、神经影像和 通过增加我们对生物和社会之间联系的理解。 过程中，该项目可能有助于确定新的干预目标，以减轻 AD 的负担 对个人、家庭和医疗保健系统的影响。

项目成果

Personal Network Bridging Potential Across Geographic Context.

个人网络跨越地理环境的桥接潜力。

• DOI: 10.1093/geronb/gbab103
• 发表时间: 2022
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Roth,AdamR;Peng,Siyun;Perry,BreaL
• 通讯作者: Perry,BreaL

Non-Spousal Support, Marital Status, and Mortality Risk.

非配偶赡养费、婚姻状况和死亡风险。

• DOI: 10.1177/08982643211025381
• 发表时间: 2022
• 期刊: Journal of aging and health
• 影响因子: 2.8
• 作者: Roth,AdamR;Peng,Siyun
• 通讯作者: Peng,Siyun

Social Isolation and Loneliness Before and During the COVID-19 Pandemic: A Longitudinal Study of U.S. Adults Older Than 50.

• DOI: 10.1093/geronb/gbab068
• 发表时间: 2022-07-05
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Peng S;Roth AR
• 通讯作者: Roth AR