Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's Disease

利用神经影像生物标志物了解社交网络在阿尔茨海默病中的作用

• 批准号: 10180831
• 负责人: LIANA G APOSTOLOVA
• 金额: $ 70.36万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10180831
• 关键词: Address; Adult; Age; Age-associated memory impairment; Aging; Alzheimer disease prevention; Alzheimer' s Disease; American; Area; Attention; Behavioral; Behavioral Mechanisms; Biological; Biological Markers; Biological Process; Biosocial; Caregivers; Characteristics; Clinical; Cognitive; Data; Data Set; Dementia; Dependence; Development; Diagnosis; Early Diagnosis; Economic Burden; Elderly; Emotional; Etiology; Exposure to; Family; Family health status; Frequencies; Funding; Goals; Health; Health Care Costs; Healthcare Systems; Home; Impaired cognition; Indiana; Individual; Intervention; Interview; Lead; Life; Linear Regressions; Link; Literature; Longevity; Measures; Mediating; Mediation; Memory; Methods; Modeling; Nerve Degeneration; Neurobehavioral Manifestations; Neurology; Pathway interactions; Pattern; Phenotype; Prevalence; Process; Property; Proxy; Research; Resources; Role; Sampling; Science; Social Behavior; Social Environment; Social Interaction; Social Network; Social Processes; Social Protection; Stimulus; Structure; Symptoms; Testing; Thick; United States National Institutes of Health; aged; care coordination; cognitive testing; cohort; constriction; dementia risk; density; disability; family burden; gray matter; improved; insight; mild cognitive impairment; neuroimaging; neuroimaging marker; neuropathology; novel; pre-clinical; prevent; ranpirnase; resilience; response; social; social engagement; tool

PROJECT SUMMARY The goal of the proposed project is to understand the role of personal social network dynamics in the etiology and clinical progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). We propose to characterize social-behavioral and biological mechanisms underlying relationships between social networks and aging-related neuropathology. AD and dementia takes a devastating toll on individuals, families, and the health care system. A critical point of intervention in AD is the social environment, which has the potential to moderate underlying neuropathology, altering the typical cognitive course of dementia. Positive social interaction – including number of confidants, frequency of social contact, support, and social engagement – is associated with reduced risk for dementia and a slower trajectory of cognitive decline among diagnosed individuals. However, the existing literature relies on limited and unidimensional measures of social interaction, and has yet to consider the role of underlying biological neurodegeneration, which manifests long before observable clinical cognitive symptoms of dementia. The proposed project addresses these gaps via three specific aims: Aim 1 is to identify baseline associations between social network characteristics and neurodegeneration (QNPs). Aim 2 is to examine longitudinal relationships between personal social network dynamics and neurodegenerative changes. Aim 3 is to evaluate alternative models of the coevolution of personal social networks and neurodegenerative changes in trajectories of clinical cognitive decline. The proposed study is interdisciplinary, combining leading-edge methods from the social and biomedical sciences, and leveraging the resources of funded centers for AD, neuroimaging, and network science. By increasing our understanding of the links between biological and social processes, this project may help identify novel targets for intervention to reduce the burden of AD on individuals, families, and the health care system.

项目摘要 拟议项目的目的是了解个人社交网络动态的作用 轻度认知障碍（MCI）和阿尔茨海默氏病的病因和临床进展 （广告）。我们建议表征依据的社会行为和生物学机制 社交网络与与衰老有关的神经病理学之间的关系。广告和痴呆症 对个人，家庭和医疗保健系统造成了破坏性的损失。一个关键点 对广告的干预是社会环境，它有可能适度基础 神经病理学，改变了痴呆症的典型认知过程。积极的社会互动 - 包括机构数量，社交接触的频率，支持和社会参与 - 是 与痴呆症风险降低以及认知能力下降较慢有关 诊断人。但是，现有文献依赖于有限和一维的 社会互动的度量，尚未考虑基本生物学的作用 神经变性，它在可观察到的临床认知症状之前很早就表现 失智。拟议的项目通过三个特定目的解决了这些差距：目标1是确定 社交网络特征与神经变性（QNP）之间的基线关联。 目标2是检查个人社交网络动态与 神经退行性变化。目标3是评估个人共同进化的替代模型 社交网络和临床认知下降轨迹的神经退行性变化。这 拟议的研究是跨学科的，结合了社会和 生物医学科学，并利用资助中心的资源进行广告，神经影像和 网络科学。通过增加我们对生物与社会之间联系的理解 过程，该项目可能有助于确定干预的新目标以减轻广告的负担 关于个人，家庭和医疗保健系统。