COBRE-DIABETES

糖尿病

• 批准号: 10252770
• 负责人: MARIANA GERSCHENSON
• 金额: $ 212.34万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10252770
• 关键词: Adipocytes; Adult; Affect; Age; Animal Model; Animals; Asians; Basic Science; Bioinformatics; Biometry; Burn injury; Cations; Cell model; Cellular Immunology; Centers of Research Excellence; Child; Childhood; Chronic; Clinical; Clinical Research; Collaborations; Complement; Cultural Diversity; Diabetes Mellitus; Diagnosis; Doctor of Philosophy; Dyslipidemias; Endocrinologist; Environment; Epigenetic Process; Ethnic group; Etiology; Faculty; Functional disorder; Funding; Future; General Population; Genomics; Goals; Grant; Hawaii; Health; Hispanics; Infrastructure; Institution; Insulin Resistance; Internet; Intervention Studies; Kidney; Leadership; Link; Medical; Mentors; Metabolic; Metabolic Diseases; Metabolic syndrome; Metabolism; Molecular; Molecular Biology; Molecular Immunology; Muscle Fibers; Native Hawaiian; Obesity; Pacific Island Americans; Physicians; Pilot Projects; Population; Positioning Attribute; Prediabetes syndrome; Prevalence; Principal Investigator; Reporting; Research; Research Personnel; Resources; Risk Factors; Science; Scientist; Structure; System; Translational Research; United States National Institutes of Health; Universities; Vascular calcification; base; clinical epidemiology; cohort; epidemiology study; ethnic diversity; ethnic minority population; experience; glucose transport; health disparity; heart disease risk; high risk; impaired glucose tolerance; improved; institutional capacity; medical schools; meetings; member; metabolic phenotype; multidisciplinary; overweight adults; overweight child; peer; peer coaching; programs; racial diversity; racial minority; recruit; research and development; senior faculty; statistics; success; translational pipeline; translational scientist; translational study

PROJECT SUMMARY/ABSTRACT - Overall The John A. Burns School of Medicine (JABSOM) at the University of Hawaii (UH) proposes to develop a multidisciplinary Hawaii-based Center of Biomedical Research Excellence (COBRE) in Diabetes Mellitus (DM). This Center will initially span departmental and eventually campus borders to promote the metabolic health of the people of Hawaii and the Pacific region. The Center will leverage Hawaii’s ability to link basic science mechanisms underlying diabetes through translational research. The overall goals are to: 1) Mentor junior investigators studying DM and insulin resistance (IR), 2) Establish a Mentoring Team, 3) Develop a Resource Core that will facilitate DM and IR research, 4) Develop future investigators using a Pilot Project Program, and 5) Recruit an Associate/Full Professor with expertise in translational DM research. The global prevalence of DM continues to increase in parallel with the expanding presence of obesity and overweight adults and children. In the US, the prevalence of DM now affects 27.9 million children and adults (8.9% of US population) (http://www.diabetes.org/diabetes-basics/statistics/). Among racial and ethnic minorities, DM prevalence exceeds that of the US general population by as much as 3-fold. We have shown that among Native Hawaiians (NHs), the prevalence of DM is 22.4% with an additional 15% diagnosed with impaired glucose tolerance or pre-diabetic status. Indeed, prior epidemiological studies on DM, IR, metabolic syndrome (MetS), and heart disease risk factors among NHs and other high risk ethnic populations in Hawaii have provided a rich environment to develop this new COBRE dedicated to understanding the molecular biology underpinnings of DM, IR and the MetS. COBRE funding will be leveraged with institutional funds to accelerate the development of research excellence in DM and IR. The research focus of the Center spans the translational spectrum with one clinical study in Native Hawaiians and Pacific Islanders focused on diabetes and immunoepigenetics. While animal and cell models are being employed in three of the four studies aimed at cation channels, glucose transport in skeletal myocytes and adipocytes, and vascular calcification and dyslipidemia in diabetes and chronic kidney deficiency within the context of IR and DM. New resources being supplemented in this proposal include funding support for a Resources Core with Epigenetics, Animal Metabolic Phenotyping and Cellular Metabolism. Pilot projects are also proposed to fund 2-3 new investigators as the initial cohort of junior investigators progress towards research independence. The JABSOM leadership will also recruit an Associate/Full Professor whose research complements and focuses on translational DM and IR.

项目摘要/摘要 - 总体 夏威夷大学（UH）的约翰·A·伯恩斯医学院（JABSOM）提出了发展 糖尿病（DM）中的基于夏威夷的多学科生物医学研究中心（COBRE）。 该中心最初将跨越部门，并最终跨越校园边界，以促进代谢健康 夏威夷和太平洋地区的人民。该中心将利用夏威夷联系基础科学的能力 通过翻译研究的糖尿病的机制。总体目标是：1）导师少年 研究DM和胰岛素抵抗的研究人员（IR），2）建立指导团队，3） 将促进DM和IR研究的资源核心，4）使用飞行员开发未来的研究人员 项目计划，以及5）招募具有翻译DM专业知识的副教/完整教授 研究。 与肥胖的存在和 超重的成年人和儿童。在美国，DM的患病率现在影响2790万儿童和成人 （美国人口的8.9％）（http://www.diabetes.org/diabetes-basics/statistics/）。在种族和种族中 少数民族的DM患病率超过了美国普通人群的患病率高达3倍。我们已经显示了 在夏威夷原住民（NHS）中，DM的患病率为22.4％，另外15％被诊断出患有 葡萄糖耐受性或糖尿病前状态受损。实际上，先前关于DM，IR，代谢的流行病学研究 NHS和其他高风险种族中的综合征（MetS）和心脏病危险因素 已经提供了一个丰富的环境，以开发这种致力于理解分子的新玉 DM，IR和Mets的生物学基础。 毛绒资金将用机构资金借用，以加速卓越研究的发展 在DM和IR中。该中心的研究重点跨越了翻译光谱，并通过一项临床研究 夏威夷原住民和太平洋岛民专注于糖尿病和免疫毛皮物质。而动物和细胞 在针对阳离子通道的四项研究中，正在雇用模型，骨骼中的葡萄糖转运 糖尿病和慢性肾脏缺乏症的肌细胞和脂肪细胞以及血管计算和血脂异常 在IR和DM的背景下。该提案中补充的新资源包括资金支持 对于具有表观遗传学，动物代谢表型和细胞代谢的资源核心。试点项目 还提议为2-3名新调查人员提供资金 研究独立性。 JABSOM领导层还将招募一位副教/完整教授，其研究 完成并专注于翻译DM和IR。