Cancer Center Support Grant

癌症中心支持补助金

基本信息

批准号：
10089808
负责人：
H. Shelton Earp
金额：
$ 782.76万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-06-01 至 2025-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10089808
关键词：
Appointment Arts Award Basic Cancer Research Basic Science Behavioral Bioinformatics Biology Budgets Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Caregivers Caring Catchment Area Chemicals Clinic Clinical Data Clinical Protocols Clinical Research Clinical Sciences Clinical Trials Communication Communities Community Outreach Comprehensive Cancer Center Consultations Data Development Direct Costs Discipline of Nursing Disease Early Diagnosis Education and Outreach Epidemiology Epigenetic Process Evaluation Research Facility Construction Faculty Fostering Funding Future Gap Junctions Genetic Research Genomic approach Government Grant Health Health Resources Health Services Healthcare Human Incidence Information Systems Infrastructure Insurance Carriers Intervention Intervention Trial Investments Leadership Malignant Neoplasms Measures Medicaid Medicare Minority Groups Mission Molecular Epidemiology Monitor Morbidity - disease rate Names North Carolina Oncology Outcome Patient Care Patients Performance Pharmacologic Substance Pharmacy facility Policies Population Population Heterogeneity Population Sciences Prevention Privatization Productivity Protocols documentation Public Health Publications Publishing Research Research Personnel Resource Sharing Resources Role Rural Population Schools Science Scientist Services Stretching System Talents Technology The Cancer Genome Atlas Therapeutic Time Training Training and Education Translating Translations United States Universities Urban Population anticancer research authority base cancer care cancer genetics cancer health disparity cancer research center director cancer therapy career college community based participatory research community college community engagement data management drug discovery epidemiology study imaging detection innovation malignant breast neoplasm medical schools member minority disparity mortality multidisciplinary neoplasm registry operation population based population health programs public policy on tobacco recruit safety net screening services senior faculty survivorship undergraduate student

项目摘要

ABSTRACT Over the past 5 years, the Center sustained its upward trajectory in cancer research excellence and service to its catchment area, the State of North Carolina. With Dr Sharpless’s appointment to NCI Director, in consultation with University leadership and the Center’s Scientific Advisors, Dr Earp was re-appointed UNC Lineberger Comprehensive Cancer Center (LCCC) Director for an additional term. The LCCC continued its exceptional performance of the past decade with respect to all important metrics including state service. Direct cost cancer research funding in 2019 increased to $161M of which over $54M comes from NCI; Center research space under the Director’s authority increased by ~10,000nsf; participation in interventional trials was over 11,000 accruals for the 5 year period; 36% of the more than 6,000 cancer related publication were collaborative; construction of a GMP facility was begun and a CAR T program was initiated with multiple INDs and 8 trials opened; and the Office of Community Outreach Engagement expanded LCCC’s traditional strength in community-based participatory research and implementation . The Center’s 324 members span the basic, clinical and population sciences organized into 9 programs with substantial inter- and intra-programmatic productivity. Faculty additions in the physical and pharmaceutical sciences created new opportunities in drug discovery, delivery, imaging and early detection. Substantial investment in faculty, technology and bioinformatics dramatically expanded cancer genetics research including leadership in the TCGA and expanded use of sequencing in clinical trials. LCCC population scientists initiated significant new efforts in cancer outcomes with recruitment and infrastructure for analyzing all cancer cases in our catchment area, as well as new endeavors in cancer communication, health access, survivorship and molecular epidemiology. Groundbreaking observations in breast cancer minority disparity research emerged from Center programs. Our basic programs continue to publish high-impact observations that are being translated into human therapeutics. A trans-Center Global Oncology effort received grants in each of the NCI’s new competitions. The Center’s continued expansion is driven by remarkable institutional support including direct support for cancer research from the state legislature. The UNC Lineberger requests continued funding for: 9 scientific programs; 13 shared resources; Clinical Protocol and Data Management; Protocol Review and Monitoring System, Developmental Funds, Planning, Leadership and Evaluation and Cancer Research and Career Enhancement The CCSG budget supports technological and operational expansion for a talented faculty integrated through cancer center mechanisms towards making advancements in the prevention, early detection, and treatment of cancer in North Carolina and the nation.

抽象的在过去的 5 年里，该中心在癌症研究的卓越性和服务方面持续保持上升势头随着 Sharpless 博士被任命为 NCI 主任，该州的辖区是北卡罗来纳州。与大学领导层和中心科学顾问协商后，厄普博士被重新任命为北卡罗来纳大学 Lineberger 综合癌症中心 (LCCC) 主任连任 LCCC 继续任职。过去十年在包括国家服务在内的所有重要指标方面都表现出色。 2019 年癌症研究经费增加至 1.61 亿美元，其中超过 5400 万美元来自 NCI 中心；主任授权下的研究空间增加了约 10,000nsf；参与介入试验的人数增加了约 10,000nsf； 5 年期间累计超过 11,000 篇；超过 6,000 篇癌症相关出版物中有 36% 合作；开始建设 GMP 设施，并启动多个 IND 的 CAR T 项目并开展了 8 个试验；社区外展参与办公室扩大了 LCCC 的传统优势以社区为基础的参与性研究和实施。该中心的 324 名成员涵盖基础科学、临床科学和人口科学，分为 9 个项目物理和药学方面的教员数量大幅增加。科学在药物发现、输送、成像和早期检测方面创造了新的机会。对师资、技术和生物信息学的投资极大地扩大了癌症遗传学研究，包括 TCGA 中的领导地位以及在 LCCC 群体科学家发起的临床试验中扩大测序的使用。通过招募和基础设施来分析所有癌症病例，在癌症结果方面做出了重大新努力我们的服务区域，以及在癌症沟通、健康获取、生存和乳腺癌少数群体差异研究出现了突破性的观察结果。我们的基本计划继续发布正在发生的高影响力的观察结果。跨中心全球肿瘤学研究成果转化为人类疗法，并获得了 NCI 各个机构的资助。新竞赛的持续扩张得益于卓越的机构支持，包括北卡罗来纳大学莱恩伯格请求继续资助州立法机构对癌症研究的直接支持。用于： 9 个科学项目； 13 个共享资源；监测系统、发展基金、规划、领导和评估以及癌症研究和职业提升 CCSG 预算支持有才华的技术和运营扩展通过癌症中心机制整合教师，以在预防、早期治疗方面取得进展北卡罗来纳州和全国的癌症检测和治疗。