Project 1: Childhood threat vs deprivation adversity: Impact of executive function, affective processing, and "real time" regulatory strategies on mental health symptoms

项目 1：童年威胁与剥夺逆境：执行功能、情感处理和“实时”监管策略对心理健康症状的影响

• 批准号: 10090779
• 负责人: Chrystal Vergara-Lopez
• 金额: $ 23.01万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090779
• 关键词: Adaptive Behaviors; Adult; Affective; Age; Attention; Biological; Categories; Centers of Research Excellence; Child; Child Abuse and Neglect; Childhood; Chronic; Cognition; Cognitive; Data; Data Analyses; Development; Dimensions; Ecological momentary assessment; Emotional; Emotions; Environment; Etiology; Executive Dysfunction; Exposure to; Female; Funding; Implicit Association Test; Individual Differences; Intervention; Laboratories; Learning; Life; Link; Mediating; Memory; Mental Health; Mental disorders; Modeling; Neurosciences; Outcome; Participant; Pathway interactions; Pattern; Persons; Phase; Process; Protocols documentation; Psychological reinforcement; Punishment; Reaction Time; Regulation; Research; Research Project Grants; Rewards; Risk; Sampling; Sexual abuse; Shapes; Stress; Symptoms; System; Technology; Technology Assessment; Testing; Thinking; Time; Trauma; attentional bias; career; childhood adversity; clinically relevant; cognitive ability; cognitive control; deprivation; emerging adult; emerging adulthood; emotion regulation; emotional abuse; emotional neglect; emotional stimulus; executive function; experience; falls; flexibility; follow-up; health assessment; indexing; maltreatment; novel; physical abuse; physical neglect; psychologic; recruit; resilience; social; theories; visual tracking; young adult

PROJECT SUMMARY / ABSTRACT COBRE Research Project 1 will enable Project Leader Vergara-Lopez to collect pilot data in support of a competitive R01 application investigating distinct “pathways” by which childhood adversity impacts emerging adult mental health. Childhood maltreatment is highly prevalent and predicts a broad range of mental health problems. Models from neuroscience suggest that distinct forms of maltreatment have different “developmental cascades” towards the emergence of mental health problems. Experiences of maltreatment characterized by deprivation (an absence of expected cognitive and social inputs from the environment) are thought to be particularly relevant in the development of “top-down” emotion regulation systems (i.e., executive functioning); whereas experiences of maltreatment characterized by threat (physical or psychological harm or threat of harm) are thought to be particularly relevant in the development of “bottom-up” emotion regulation systems (i.e., reinforcement sensitivity, associative memory, attentional bias). Yet no studies have examined the downstream effects of deprivation and threat assessed in “real-time,” nor have any studies comprehensively examined these effects in relation to mental health symptoms in young adulthood. This project will provide the first comprehensive test of the differential effects of deprivation and threat and examine links to real-world emotion regulation and mental health. A sample of emerging adults (ages 18-25) varying in level of exposure to childhood maltreatment (n=150; 50% female) will be recruited. Participants will complete a baseline laboratory session assessing “top-down” and “bottom-up” processes and mental health symptoms. “Top-down” and “bottom up” processes will be assessed by a state-of-the-field battery of laboratory tasks including assessment of multiple components of executive functioning (that differentiate between cognitive abilities in the presence vs absence of emotional information), individual differences in reaction time contingent on reward and punishment, a novel self-referential Single-Category Implicit Association Test (that indexes both positive and negative self-referential memory), and a free-viewing eye tracking paradigm capturing orientation and duration of attention to threat. Leveraging Ilumivu technology from the Technology, Assessment, Data, and Analysis (TADA) Core, participants will then complete a 30-day Ecological Momentary Assessment (EMA) protocol assessing “real-time” emotion regulation strategies (repetitive negative thinking and reappraisal) and hallmark mental health symptoms. A final laboratory session will re-assess a full spectrum of mental health functioning. Results from this study will reveal downstream effects of childhood maltreatment on emotion regulation (as it unfolds in daily life) and mental health outcomes. This study has the potential to elucidate distinct and clinically relevant etiological pathways by which adversity impacts mental health, and can inform a new wave of etiologically tailored interventions that can be deployed using technology.

项目摘要 /摘要 COBRE研究项目1将使项目负责人Vergara-Lopez能够收集药丸飞行员数据，以支持 竞争性R01应用程序调查了不同的“途径”，儿童逆境会影响新兴 成人心理健康。 来自神经科学的模型表明，不同形式的虐待具有不同的“发展” 级联”“解决心理健康问题的出现。 剥夺（没有环境中没有预期的认知和社会投入）是 与“自上而下”的情绪调节系统（即执行功能）的发展特别相关； 而虐待经历以线程为特征 危害）被认为与“自下而上”的情绪调节系统的发展特别相关 （即增强敏感性，关联记忆，注意力偏见）。 剥夺和威胁的下游影响“实时”，也没有任何研究 全面研究了与成年年轻人心理健康症状有关的这些影响。 该项目将对剥夺和线程的差异效应提供首次综合测试。 并检查与现实世界情绪调节和心理健康的链接。 18-25）将招募儿童虐待的暴露水平（n = 150; 50％女性）。 参与者将完成一项基线实验室会议，评估“自上而下”和“自下而上”的流程以及 心理健康症状。 一系列实验室任务，包括评估执行功能的多个组件（That） 在存在的情况下与缺乏情感信息的认知能力区分，个人 反应时间的差异取决于奖励和惩罚，这是一种新颖的自我重生单类别 隐式关联测试 利用Ilumivu技术 从技术，评估，数据和分析（TADA）核心中，参与者将获得30天 生态瞬时评估（EMA）协议评估“实时”情绪调节策略 （重复的负面思维和重新评估）和标志性心理健康症状。 将重新评估各种心理健康功能。 儿童虐待对情绪调节的影响（随着日常生活的发展）和心理健康成果。 这项研究有潜力阐明不同的与临床相关的病因途径 影响心理健康，并可以向可以部署的病因量身定制干预措施提供新的信息 使用技术。