Project 1: Childhood Maltreatment, Repetitive Negative Thinking, and Mental Health in Adolescence: A 12-Year Longitudinal Study

项目 1：童年期虐待、重复性消极思维和青春期心理健康：一项为期 12 年的纵向研究

• 批准号: 10686044
• 负责人: Chrystal Vergara-Lopez
• 金额: $ 19.27万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686044
• 关键词: Adaptive Behaviors; Adult; Affective; Age; Attention; Case Study; Categories; Centers of Research Excellence; Child; Child Abuse and Neglect; Childhood; Chronic; Cognition; Cognitive; Data; Development; Dimensions; Ecological momentary assessment; Emotional; Emotions; Environment; Etiology; Executive Dysfunction; Exposure to; Female; Funding; Health; Implicit Association Test; Individual Differences; Intervention; Laboratories; Learning; Life; Link; Mediating; Memory; Mental Health; Mental disorders; Modeling; Neurosciences; Outcome; Participant; Pathway interactions; Pattern; Persons; Phase; Process; Protocols documentation; Psychological reinforcement; Punishment; Reaction Time; Regulation; Research; Research Project Grants; Rewards; Risk; Risk Factors; Sampling; Severities; Sexual abuse; Shapes; Stress; Symptoms; System; Technology; Testing; Thinking; Time; Trauma; attentional bias; career; childhood adversity; clinically relevant; cognitive ability; cognitive control; deprivation; emerging adult; emerging adulthood; emotion regulation; emotional abuse; emotional neglect; emotional stimulus; executive function; experience; falls; flexibility; follow-up; forging; health assessment; indexing; maltreatment; novel; personalized medicine; physical abuse; physical neglect; psychologic; recruit; resilience; resilience factor; social; synergism; theories; visual tracking; young adult

PROJECT SUMMARY / ABSTRACT COBRE Research Project 1 will enable Project Lead Vergara-Lopez to collect pilot data in support of a competitive R01 application investigating the influence of childhood maltreatment on repetitive negative thinking (RNT), and risk for mental health problems. Early life adversity alters cognitive processes; these effects become more evident as children transition to adolescence. However, the cognitive mechanisms by which childhood adversity confers risk for adolescent psychopathology are not well understood. We propose that cognitive control deficits, specifically poor set-shifting when processing emotional stimuli, leads to difficulty disengaging from negative content and experiences of repetitive negative thinking (RNT). RNT - a recurrent and difficult to control process focused on negative content has been proposed as a transdiagnostic cognitive risk factor across internalizing (e.g., depression, anxiety) and externalizing (e.g., substance use, aggression) problems. Yet, there are no studies that examine the role of RNT as it unfolds in vivo among adolescents with exposure to childhood adversity. This is a critical missed clinical opportunity because RNT may serve as a proximal malleable antecedent to a broad range of mental health problems, and thus, a potential transdiagnostic treatment target. Adolescents with comprehensive child protective services verified histories of maltreatment and other adversities (determined by contextual stress interviews, and self/parental report), will be recruited from a 12-year longitudinal study. We will capitalize on the infrastructure of this longitudinal study that has richly characterized maltreatment and other adverse exposures utilizing multi-method, multi-informant assessment of maltreatment in early childhood (ages 3-5) and middle childhood (ages 9-11) across exposure type, chronicity, and severity. We will recruit adolescents between 15-17 years old and a caregiver. Adolescents (N=75), and their caregivers will attend a laboratory visit to assess mental health via diagnostic clinical interviews and self-report measures. The adolescents will complete a cognitive control battery, a RNT induction paired with a free-view eye-tracking paradigm to assesses difficulty disengaging from negative content (i.e., how much participants visually dwell or perseverate on negative stimuli). Leveraging Ilumivu technology from the Technology, Assessment, Data, and Analysis (TADA) Core, adolescents will then complete a short-term EMA burst design with two, 2-week, EMA protocols at baseline and at a 6-month follow-up, assessing “real-time” RNT and cardinal mood symptoms of a broad spectrum of mental health problems (e.g., depressed, anxious, irritable, and angry mood). Finally, participants will complete a second laboratory visit to reassess full spectrum mental health via self-report and interviews. Ultimately, this research will inform the development of technology deployed ecological momentary interventions (EMIs) or just-in-time adaptive interventions (JITAIs) that vary based on real-time needs (e.g., in-vivo RNT) and help prevent and curtail mental health problems following childhood adversity.

项目摘要 /摘要 Cobre Research Project 1将使Vergara-Lopezt Pillot Pilot数据支持竞争性R01申请申请投资依赖儿童虐待态思维（RNT）E流程，但是随着儿童的过渡性，这些效果变得明显。我们认为认知控制缺陷情绪刺激，从而导致与负面含量的差异和实验性负面思维（RNT）。 ，物质使用，侵略性问题。 ，一个潜在的转诊治疗靶点。 -11）在曝光范围内，我们将在15-17之间招募青少年！有多少参与者在负面刺激上居住在负面的刺激上）。为期6个月的随访，评估了实时的“实时”，参与者将通过自我报告和访谈完成第二次实验室访问，以重新访问特殊的健康心理健康。 （EMI） - 根据实时需求（例如，体内rnt）的时间自适应干预措施（JITAI），并有助于预防和减少儿童逆境后的心理健康问题。