Functional MRI Core Facility

功能性核磁共振核心设施

• 批准号: 10266650
• 负责人: Peter Bandettini
• 金额: $ 542.12万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10266650
• 关键词: 10 year old; 3-Dimensional; Agreement; Area; Atlases; Award; Biological Markers; Blood Volume; Brain; COVID-19; Central Vein; Charge; Chills; Clinical; Collaborations; Communities; Computer software; Core Facility; Data; Data Collection; Data Science; Data Set; Data Storage and Retrieval; Databases; Deposition; Detection; Development; Digital Imaging and Communications in Medicine; Disease; Educational process of instructing; Educational workshop; Electroencephalography; Electronics; Environment; Equilibrium; Evaluation; Extramural Activities; Eye; Feedback; Financial compensation; Floor; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Goals; Head; Hour; Human; Image; Individual; Information Technology; Infrastructure; Institutes; International; Interruption; Iron; Laboratories; Lamivudine; Language; Lead; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Maintenance; Measures; Medical; Methodology; Methods; Modernization; Modification; Motion; Multiple Sclerosis Lesions; Myelin; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; Noise; Nuclear Magnetic Resonance; Ontario; Paper; Peer Review; Penetration; Persons; Physiologic pulse; Police; Predisposition; Principal Investigator; Procedures; Process; Protocols documentation; Publications; Publishing; Ramp; Records; Research; Research Personnel; Research Support; Resolution; Resources; Role; Running; Safety; Scanning; Schedule; Scientist; Secure; Sensory; Services; Slice; Specialist; Speed; Structure; System; Testing; Time; Traction; Training; Translating; United States National Institutes of Health; Universities; Update; Variant; Vertebral column; Vision; Water; Water Supply; Work; base; computerized data processing; data archive; data sharing; deep learning; density; design; functional magnetic resonance imaging/electroencephalography; imaging facilities; imaging modality; improved; indexing; instrumentation; multimodality; neurofeedback; neuroimaging; neuroregulation; operation; pandemic disease; prisma; programs; prototype; response; symposium; telework; trend; virtual; web platform

Space Utilization: The Functional Magnetic Resonance Imaging Facility (FMRIF) currently occupies approximately 5000 sq ft of space in Building 10, divided between the B1level scanner bays, control rooms and electronics/machine rooms for 3TA/3TB, 3TC, and the Siemens 7T-Classic, (about 1800 sq ft, 1100 sq ft and 1300 sq ft respectively) and office space within the Nuclear Magnetic Resonance (NMR) center. On the first floor are the Functional MRI Facility and the Section on Functional Imaging Methods suites (approximately 800 sq ft total) for office space and shared conference space for all staff employed full-time by the facility. Staff: The FMRIF staff consists of: the facility director, four staff scientists to keep the scanners running, six MRI technologists, an information technology specialist, and an administrative laboratory manger. Investigators: The functional MRI facility supports the research of over 30 Principal Investigators translating to over 300 researchers overall. Over 70 research protocols are active and making use of FMRIF scanners. Each scanner has scheduled operating hours of 105 hours per week. Papers published using the core: A strong measure of the utility of a core facility is the quantity and quality of scientific papers published by investigators using the facility. We have kept careful records of papers published and their corresponding citations, such that we have been able to create a core facility h-index. Since its inception in 2000 until August 2020, a total of 1,222 peer-reviewed publications from intramural investigators have used data acquired in the FMRIF core facility. The total is distributed among 700 papers from NIMH, 345 papers from NINDS, and 148 from the other institutes. These papers have been cited a total of 140,641 times for a combined h-index of 185. In other words, 185 papers using the FMRIF have been cited at least 185 times. Core Projects of the Staff Scientists: Linqing Li Dr. Li helped providing service for a TMS-fMRI coil test and safety verification and application. The project was interrupted early this year due to pandemic, however, last month, the TMS group requested another service for resuming this procedure. He has restored and updated the procedure for the coil installation and MRI protocol evaluation on phantom. Dr. Li has also been very active scientifically. He has been collaborating with Dr. Yuhui Chai on high resolution functional pulse sequence development. He has also been continuing his ongoing development on DANTE-prepared EPI for both imaging blood volume changes as well as towards baseline CMRO2 mapping. Vinai Roopchansingh Dr. Roopchansingh has continued the development of a system that enables neuro-feedback data the GE and Siemens systems. This system has been made publicly available at https://pypi.org/project/afniRTI/ He has also received, tested, and deployed several versions of research EPI prototype sequences from GE including a multi-band EPI prototype being used by SFIM on FMRIF 3TB. Recently, he implemented a multi-band, multi-echo enabled prototype from GE. FY 2020 involved multiple larger purchasing acquisitions. He recently completed the procurement for a maintenance agreement for all of our GE scanners, which will provide coverage for the next 5 years. His is also in the process of procuring a 32-channel head coil from Nova Medical for us, and in the midst of the procurement for a commercial option to replace our current web platform that makes DICOM data available to our users. It should be noted that Dr. Roopchansingh's response to COVID-19-related scheduling and management of the technologists as research slowly returns to the FMRIF has been exemplary. He formulated a return to work plan, and personally oversees scanning requests and technologist schedules to make sure operations ramp up smoothly and safely. Sean Marrett Dr. Marrett collaborated on pulse sequence debugging, testing and a data collection using VASO methods and variants with Dr. Laurentius Huber of Maastricht University with the goal of whole-brain layer-specific MRI. Data was collected on both the FMRIF-7T (VB17) as well as the more modern NMRF-7T (VE12). This included the tests of the MAGEC-VASO methods. FMRIF was given approval for supplementary funding for an upgrade of our current FMRIF-7T (now more than 10 years old in design) , and a 2nd a new, modern human 7T system which will replace one of our GE MR750 3T scanners. Dr. Marrett has been the main point of contact for these new 7T projects. Dr. Marrett deployed an eye-tracker and screen assembly for the 3T systems in collaboration with the Section on Instrumentation and Dr. Danny Pine. FMRIF continues to work closely with Dr. Peter Molfese (CMN/SFIM) to support concurrent high-density EEG data collection. FMRIF was given approval and supplementary funding for a new scientific imaging database. This project was initiated by Dr. Marrett and is now being led by Dr. Roopchansingh. This will be integrated with long-planned improvements to our data storage area network (SAN) that is the backbone of the FMRIF computing and data archiving network and will increase the capacity and speed of access to storage significantly. Andy Derbyshire Dr. Derbyshire continues to be the FMRIF lead in the FMRIF/NIBIB insertable head gradient project. In the last year this has included planning/construction and, increasingly early experimental work. The upgrades to the chilled water supply and modifications to the penetration panels etc. of 3TB were completed to accommodate the insertable head gradient (Pierpaoli/NIBIB). The insertable head gradient unit was delivered at the end of 2019 with the first installation and demonstration of the unit being performed by the Brian Rutt's team (Stanford/U. Western Ontario) in early 2020. The insertable head-gradient provides 120mT/m max gradient with 1200T/m/s slew rate (to be compared with 50mT/m 200T/m/s clinical gradients) allowing a single slice of 3-echo, non-accelerated EPI at 2mm resolution to be acquired in less than 100ms. The 10kW of heat generated in the coil by running this sequence continuously is being successfully removed by the cooling system comprising chilled water through hollow conductors. He provided support installing and maintaining the Siemens Pulse Sequence development environment for the various platforms within the MR Center, including support for the FMRIF7T (VB17), NMRF7T (VE12U), 3TD/Skyra (VD13A and VE11C) and Prisma (VD13D) platforms as well as assistance with pulse-sequence programming related issues. He is continuing to work with Pascal Sati (Riech/NINDS) in the development of their susceptibility contrast 3D-EPI pulse sequence for detection of the central vein in MS lesions. He is the FMRIF representative on the NMR Safety Committee. We support for the NMRF Human Safety Class (which includes educating users about MR Safety in general as well as the Rules and Polices for human scanning in the NMR Center). The Safety Class team is developing a new on-line refresher course to help meet the requirement that all NMR Center users re-certify their safety training at least every two years. We have also, in response user demand during the COVID-19/max-telework situation, adapted the course to provide virtual Safety Classes which are now being regularly scheduled. Beyond teaching the safety class sessions, the NMR Safety Class team is actively involved in developing the polices within the NMR Center to meet the changes and new standards being introduced for Human MRI scanning. In June 2020, Dr. Derbyshire assisted with the planning and running of the Gadgetron 2020 online summer course, including teaching a small session.

空间利用率： 功能磁共振成像设施 (FMRIF) 目前在 10 号楼占据约 5000 平方英尺的空间，分为 B1 层扫描仪隔间、3TA/3TB、3TC 和西门子 7T-Classic 的控制室和电子/机械室，（分别约1800平方英尺、1100平方英尺和1300平方英尺）以及核磁内的办公空间共振 (NMR) 中心。一楼是功能性 MRI 设施和功能性成像方法套房（总面积约 800 平方英尺），为该设施所有全职员工提供办公空间和共享会议空间。 职员： FMRIF 工作人员包括：设施主任、四名负责保持扫描仪运行的科学家、六名 MRI 技术专家、一名信息技术专家和一名实验室行政经理。 调查人员： 功能性 MRI 设施支持 30 多名首席研究员的研究，即总共 300 多名研究人员的研究。超过 70 个研究方案正在使用 FMRIF 扫描仪。每台扫描仪的预定运行时间为每周 105 小时。 使用核心发表的论文： 衡量核心设施效用的一个重要指标是研究人员使用该设施发表的科学论文的数量和质量。我们仔细记录了发表的论文及其相应的引用，以便我们能够创建核心设施 h 指数。 自 2000 年成立以来至 2020 年 8 月，校内研究人员总共发表了 1,222 份同行评审出版物，使用了在 FMRIF 核心设施中获取的数据。总共分布在 NIMH 的 700 篇论文、NINDS 的 345 篇论文以及其他机构的 148 篇论文中。这些论文总共被引用了 140,641 次，综合 h 指数为 185。换句话说，使用 FMRIF 的 185 篇论文至少被引用了 185 次。 职员科学家的核心项目： 李临清 李博士帮助提供了TMS-fMRI线圈测试和安全验证及应用服务。该项目于今年年初因大流行而中断，然而，上个月，TMS 小组请求另一项服务来恢复该程序。他恢复并更新了体模上线圈安装和 MRI 协议评估的程序。 李博士在科学上也非常活跃。他一直与柴宇辉博士合作开发高分辨率功能脉冲序列。他还一直在继续开发 DANTE 准备的 EPI，用于成像血容量变化以及基线 CMRO2 映射。 维奈·鲁普查辛 Roopchansingh 博士继续开发一个系统，使 GE 和西门子系统能够提供神经反馈数据。 该系统已在 https://pypi.org/project/afniRTI/ 上公开发布 他还接收、测试并部署了 GE 提供的多个版本的研究 EPI 原型序列，包括 SFIM 在 FMRIF 3TB 上使用的多频段 EPI 原型。 最近，他实现了 GE 的多频段、多回波原型。 2020 财年涉及多项规模较大的采购收购。 他最近完成了我们所有 GE 扫描仪维护协议的采购，该协议将提供未来 5 年的保修服务。 他还正在为我们从 Nova Medical 采购 32 通道头部线圈，并正在采购商业选项以取代我们当前的网络平台，使 DICOM 数据可供我们的用户使用。 值得注意的是，随着研究慢慢返回 FMRIF，Roopchansingh 博士对与 COVID-19 相关的技术人员调度和管理的反应堪称典范。他制定了重返工作计划，并亲自监督扫描请求和技术人员时间表，以确保运营顺利、安全地进行。 肖恩·马雷特 Marrett 博士与马斯特里赫特大学的 Laurentius Huber 博士合作使用 VASO 方法和变体进行脉冲序列调试、测试和数据收集，目标是实现全脑层特异性 MRI。数据是在 FMRIF-7T (VB17) 以及更现代的 NMRF-7T (VE12) 上收集的。这包括 MAGEC-VASO 方法的测试。 FMRIF 获得了补充资金的批准，用于升级我们当前的 FMRIF-7T（设计已有 10 多年），以及第二个新的现代人体 7T 系统，该系统将取代我们的一台 GE MR750 3T 扫描仪。 Marrett 博士是这些新 7T 项目的主要联系人。 Marrett 博士与仪器部门和 Danny Pine 博士合作，为 3T 系统部署了眼动仪和屏幕组件。 FMRIF 继续与 Peter Molfese 博士 (CMN/SFIM) 密切合作，支持并发高密度脑电图数据收集。 FMRIF 获得了新科学成像数据库的批准和补充资金。该项目由 Marrett 博士发起，目前由 Roopchansingh 博士领导。 这将与我们长期计划的数据存储区域网络 (SAN) 改进相结合，该网络是 FMRIF 计算和数据归档网络的支柱，并将显着提高存储访问的容量和速度。 安迪·德比希尔 Derbyshire 博士继续担任 FMRIF/NIBIB 可插入头部梯度项目的 FMRIF 负责人。 去年，这包括规划/建设以及越来越多的早期实验工作。 3TB 的冷冻水供应升级和渗透板等改造已完成，以适应可插入头梯度 (Pierpaoli/NIBIB)。 可插入头部梯度装置于 2019 年底交付，Brian Rutt 团队（斯坦福大学/西安大略大学）于 2020 年初对该装置进行了首次安装和演示。可插入头部梯度装置最大提供 120mT/m 1200T/m/s 斜率梯度（与 50mT/m 200T/m/s 临床梯度相比）允许单个3 回波、非加速 EPI 切片，分辨率为 2 毫米，可在 100 毫秒内采集。 连续运行该序列在线圈中产生的 10kW 热量已被冷却系统成功消除，该系统包括通过空心导体的冷冻水。 他为 MR 中心内的各种平台安装和维护西门子脉冲序列开发环境提供了支持，包括对 FMRIF7T (VB17)、NMRF7T (VE12U)、3TD/Skyra（VD13A 和 VE11C）和 Prisma (VD13D) 平台的支持以及脉冲序列编程相关问题的帮助。 他继续与 Pascal Sati (Riech/NINDS) 合作开发磁敏对比 3D-EPI 脉冲序列，用于检测多发性硬化症病变中的中央静脉。 他是 NMR 安全委员会的 FMRIF 代表。我们支持 NMRF 人体安全课程（其中包括对用户进行有关 MR 安全的一般教育以及 NMR 中心人体扫描的规则和政策）。 安全课程团队正在开发新的在线进修课程，以帮助满足所有 NMR 中心用户至少每两年重新认证其安全培训的要求。 为了响应 COVID-19/最大远程办公​​情况下的用户需求，我们还对课程进行了调整，以提供虚拟安全课程，目前正在定期安排课程。 除了教授安全课程之外，NMR 安全课程团队还积极参与 NMR 中心内政策的制定，以满足人体 MRI 扫描的变化和新标准的要求。 2020年6月，Derbyshire博士协助Gadgetron 2020在线暑期课程的规划和运行，包括教授一个小型课程。