Functional MRI Core Facility

功能性核磁共振核心设施

基本信息

批准号：
10703967
负责人：
Peter Bandettini
金额：
$ 445.09万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10703967
关键词：
Archives Area Back Blood Volume Blood flow Brain Brain imaging Charge Clinical Research Cognition Collaborations Communities Computer software Core Facility Data Data Collection Data Science Data Set Databases Deposition Development Digital Imaging and Communications in Medicine Educational process of instructing Educational workshop Electroencephalography Electronics Ensure Environment Extramural Activities FDA approved Feedback Financial compensation Floor Functional Imaging Functional Magnetic Resonance Imaging Goals Head Holly Hour Human Image Information Technology Infrastructure Ingestion Institutes Internet Iron Laboratories Lamivudine Lead Machine Learning Magnetic Resonance Imaging Manuscripts Methodology Methods Modality Motion Myelin National Institute of Biomedical Imaging and Bioengineering National Institute on Alcohol Abuse and Alcoholism Noise Nuclear Magnetic Resonance Paper Patients Phase Photic Stimulation Physiologic pulse Play Positioning Attribute Positron-Emission Tomography Postdoctoral Fellow Preparation Principal Investigator Process Production Protocols documentation Publishing Pythons RF coil Ramp Real-Time Systems Reproducibility Research Research Personnel Research Support Resolution Resources Role Running Safety Scanning Schedule Scientist Secure Services Side Source Specialist Specificity Spectrum Analysis Stream Surface System Technology Testing Time Training Translating United States National Institutes of Health Update Variant Vendor Vision Work base brain metabolism cerebral blood volume clinical development college computerized data processing data acquisition data sharing deep learning density experimental study falls functional magnetic resonance imaging/electroencephalography imaging facilities imaging modality improved interest meetings member millisecond multimodal neuroimaging neuroimaging neuroregulation novel strategies open source operation platform-independent repaired signal processing symposium trend virtual visual tracking web services

项目摘要

Space Utilization: The Functional Magnetic Resonance Imaging Facility (FMRIF) currently occupies approximately 5000 sq ft of space in Building 10, divided between the B1level scanner bays, control rooms and electronics/machine rooms for 3TA/3TB, 3TC, and the Siemens 7T-Classic, (about 1800 sq ft, 1100 sq ft and 1300 sq ft respectively) and office space within the Nuclear Magnetic Resonance (NMR) center. On the first floor are the Functional MRI Facility and the Section on Functional Imaging Methods suites (approximately 800 sq ft total) for office space and shared conference space for all staff employed full-time by the facility. Staff: The FMRIF staff consists of: the facility director, four staff scientists to keep the scanners running, one staff scientist for the center for multimodal neuroimaging, six MRI technologists, and an information technology specialist. Investigators: The functional MRI facility supports the research of about 30 Principal Investigators translating to over 300 researchers overall. Over 70 research protocols are active and making use of FMRIF scanners. Each scanner has scheduled operating hours of 105 hours per week. Core Projects of the Staff Scientists: Vinai Roopchansingh Dr. Roopchansingh has continued working with the vendor for our new DICOM web service to complete ingestion of all of FMRIFs archive DICOM data, into FMRIFs XNAT instance. He worked with the vendor to provide Zoom-hosted training sessions for users of FMRIFs XNAT instance, and hope to move this instance into production, before the end of this fiscal year. He also worked with another vendor to develop an updated web scheduling application for FMRIF scanner schedules. This will require much more work and effort to bring into production, but the base work has been completed, and the new application is ready to be tested, and to start integration into NIHs infrastructure. He continues assisting with bringing FMRIFs newest scanner (a Siemens 7T Terra) out of the construction phase, and again almost ready for users and patients to run their studies on. Coincident with this, he completed the transition of the scanner schedules, that changed when FMRIF converted one of its 3T systems to 7T. On the technical side of operations, Dr. Roopchansingh worked with multiple groups (mostly in the Laboratory of Brain and Cognition) to roll out a multi-band, multi-echo EPI sequence for FMRIFs GE scanners. Already, approximately a handful of projects of have used this sequence for FMRI data acquisition, and in conjunction with this, he has fed back changes FMRIF and NIH have made to this pulse sequence, to GE, that makes it more useful for FMRI studies. Finally, he started development on a new-real time system, that could drive AFNI and other applications based on the states of FMRIFs MRI scanners. This originated in work done by Jerzy Bodurka for FMRIF General Electric scanners. However now, given the mix between GE and Siemens that FMRIF owns and operates, a platform independent solution was in development, and is now at a state where it can publish the state that either vendor's scanners are in, at any given time. Linqing Li Dr. Linqing Li has continued to provide service and assistance to the noninvasive neuromodulation unit headed by Holly Lisanby. He has also been active scientifically in two major projects. The first resulted in a paper, published in November of 2021, Quantification of cerebral blood volume changes caused by visual stimulation at 3 T using DANTE-prepared dual-echo EPI. This is a novel approach that relies on a grid of rapidly applied RF pulses to characterize blood volume and oxygenation over time. Second, he has been working on a manuscript that advances further establishment of the relationship between brain metabolism and blood flow. He is collaborating with Prof. Nicholas Blockley and the paper is still in the process of being written up. Sean Marrett Dr. Marrett was the project officer for the 7TB-FMRIF project, replacing a 3 Tesla MRI system with a 7T human scanner (the first FDA-approved 7T system). Dr. Marrett handled this project's contractual and technical details in close collaboration with his FMRIF colleagues, Dr. Derbyshire and Dr. Roopchansingh. This major project is complete with the old magnet removed in the fall of 2021 and the new magnet delivered in March. The system began collecting test data in July of 2022, and we expect full operations to commence by September 1st. This system will provide the FMRIF community with an FDA-approved 7T scanner, crucial for clinical studies, and increase our ability to carry out the highest resolution FMRI available. The acquisition includes multiple multi-nuclear coils, advancing our ability to carry out spectroscopy studies with FDA-approved RF-coils. Furthermore, the new platform has vastly improved the technical capacity for parallel-transmit FMRI, which shows promise for improving both resolution and specificity and reducing inhomogeneity in imaging the brain. Repair of damaged gradient coil on 7TA-FMRIF Dr. Marrett played a crucial role in ensuring the return to service of our original 7TA-FMRIF, which required persistent and detailed technical and contractual expertise to provide the needed support for this workhorse 7T. n collaboration with members of the Laboratory of Brain and Cognition (LBC), 7T eye tracking is now routine on 7TA-FMRIF. Thru Dr. Marrett, FMRIF collaborates closely with Dr. Peter Molfese (CMN) to support concurrent high-density EEG data collection on all of our 3T scanners. IT Infrastructure and new scientific imaging database Work continued deploying a new scientific imaging database based on the open-source XNAT platform. FMRIF has begun to integrate this new database into the routine scanning workflow. Dr. Marrett has supported Dr. Roopchansingh (overall scientific database project lead) with bi-weekly project meetings and feedback to the software vendor. Transition: Dr. Marrett began preparations for his separation from the Functional MRI Facility for a new position at Dartmouth College. Responsibilities for IT infrastructure were passed on to Dr. Roopchansingh, while Dr. Derbyshire has assumed responsibilities for the new 7TB-FMRIF. John (Andy) Derbyshire During 2021, Andy assumed responsibility from Vinai Roopchansingh to provide coordination of the FMRIF user community with the FMRIF MRI Technologists. Dr. Derbyshire continues to be the FMRIF lead in the FMRIF/NIBIB insertable head gradient project. He worked with Dr. Pierpaoli (NIBIB) to acquire an MR field camera which can accurately determine the variations of the gradient fields used for MR image encoding. He provides support installing and maintaining the Siemens Pulse Sequence development environment within the MR Center, including support for all five FMRIF MRI systems plus the NMRF 7T and NIAAA 3T scanners as well as assistance to users with pulse-sequence programming. Dr. Derbyshire is deeply involved with NMR Center safety training and is a member of the safety committee.

空间利用：目前，建筑物10的功能磁共振成像设施（FMRIF）目前占据了大约5000平方英尺的空间，在B1Level扫描仪托架，控制室和电子/机床之间进行了3TA/3TB，3TC，3TC，SIEMENS 7T-CLASSIC内部的核电室（大约1800平方英尺）（大约1800平方ft，1100 SQ FT，1100 SQ FT和1300 SQ FT）共振（NMR）中心。一楼是功能性MRI设施和功能成像方法套件（总计约800平方英尺）的办公空间和共享会议空间的部分，用于该设施全职工作的所有员工。职员： FMRIF员工包括：设施主管，四名员工科学家，以保持扫描仪的运行，一名多模式神经影像中心的员工科学家，六位MRI技术人员和一名信息技术专家。调查人员：功能性MRI设施支持大约30名主要研究人员的研究，这些研究人员总体上转化为300多名研究人员。超过70种研究方案是活跃的，并利用了FMRIF扫描仪。每个扫描仪计划每周工作105小时。员工科学家的核心项目： Vinai Roopchansingh Roopchansingh博士继续与供应商合作为我们的新DICOM Web服务，以将所有FMRIFS存档DICOM数据摄入FMRIFS XNAT实例。他与供应商合作，为FMRIFS XNAT实例的用户提供Zoom主持的培训课程，并希望在本财政年度结束之前将此实例转移到生产中。他还与另一位供应商合作，为FMRIF扫描仪计划开发更新的Web计划应用程序。这将需要更多的工作和精力来投入生产，但是基础工作已经完成，新应用程序已准备好进行测试，并开始集成到NIHS基础架构中。他继续协助将fMRIFS最新的扫描仪（西门子7T Terra）带出建筑阶段，几乎可以供用户和患者进行研究。与此相吻合，他完成了扫描仪时间表的过渡，当FMRIF将其3T系统之一转换为7T时，这种情况发生了变化。在操作的技术方面，Roopchansingh博士与多个组（主要是在大脑和认知实验室）一起推出了用于FMRIFS GE扫描仪的多波段的多回波EPI序列。已经大约有少数项目已将此序列用于fMRI数据采集，并且与此同时，他对FMRIF和NIH对GE进行了反馈更改，这使其对fMRI研究更有用。最后，他开始在新的时间系统上开发，该系统可能会根据FMRIFS MRI扫描仪的状态推动AFNI和其他应用程序。这起源于Jerzy Bodurka为FMRIF通用电扫描仪完成的工作。但是，鉴于FMRIF拥有和运营的GE与Siemens之间的混合，正在开发平台独立的解决方案，现在处于一个州，可以在任何给定时间发布该州，即供应商的扫描仪都在任何给定时间。 linqing li Linqing Li博士继续为由Holly Lisanby领导的非侵入性神经调节单元提供服务和帮助。他还科学地在两个主要项目中积极活跃。第一篇论文于2021年11月发表，使用Dante Par-Preged Dual-Echo Epi对3 t的视觉刺激引起的脑血容量变化进行定量。这是一种新的方法，它依赖于快速施加的RF脉冲的网格来表征随着时间的推移血液体积和氧合的表征。其次，他一直在研究一个手稿，该手稿进一步建立了脑代谢与血流之间的关系。他正在与尼古拉斯·布洛克利（Nicholas Blockley）教授合作，该论文仍在写作。肖恩·马雷特（Sean Marrett） Marrett博士是7TB-FMRIF项目的项目官员，用7T人类扫描仪（第一个FDA批准的7T系统）代替了3 Tesla MRI系统。 Marrett博士与他的FMRIF同事Derbyshire博士和Roopchansingh博士密切合作处理了该项目的合同和技术细节。这个重大项目已完成，旧磁铁在2021年秋天删除，新磁铁在3月交付。该系统于2022年7月开始收集测试数据，我们预计将在9月1日之前开始全面操作。该系统将为FMRIF社区提供经FDA批准的7T扫描仪，对于临床研究至关重要，并提高了我们执行最高分辨率fIMRI的能力。该采集包括多个多核线圈，推进了我们使用FDA批准的RF-ails进行光谱研究的能力。此外，这个新平台已大大提高了并行传播fMRI的技术能力，这表明有望改善分辨率和特异性并降低大脑成像的不均匀性。修复7TA-FMRIF上受损梯度线圈的维修 Marrett博士在确保我们最初的7TA-FMRIF恢复服务方面发挥了至关重要的作用，该公司需要持续且详细的技术和合同专业知识，以为这款士兵7T提供所需的支持。 N与大脑和认知实验室成员（LBC）的合作，7T眼跟踪现在是7TA-FMRIF的常规方法。 FMRIF博士通过Marrett博士与Peter Molfese博士（CMN）紧密合作，以支持我们所有3T扫描仪的并发高密度EEG数据收集。 IT基础架构和新的科学成像数据库工作继续基于开源XNAT平台部署新的科学成像数据库。 FMRIF已开始将此新数据库集成到常规扫描工作流程中。 Marrett博士支持Roopchansingh博士（整体科学数据库项目负责人），每两周一次的项目会议和对软件供应商的反馈。过渡： Marrett博士开始为他与功能性MRI设施分开的准备工作，担任达特茅斯学院的新职位。 IT基础设施的责任转交给了Roopchansingh博士，而Derbyshire博士已经承担了新的7TB-FMRIF的责任。约翰（安迪）德比郡在2021年期间，安迪（Andy）承担了Vinai Roopchansingh的责任，要求与FMRIF MRI技术人员提供FMRIF用户社区的协调。 Derbyshire博士仍然是FMRIF/NIBIB插入的头部梯度项目中的FMRIF领导者。他与Pierpaoli博士（Nibib）合作，购买了MR现场摄像机，该相机可以准确地确定用于MR图像编码的梯度场的变化。他提供了在MR中心内安装和维护西门子脉冲序列开发环境的支持，包括对所有五个fMRIF MRI系统以及NMRF 7T和NIAAA 3T 3T扫描仪的支持，以及为具有脉冲序列编程的用户提供帮助。德比郡博士深入参与NMR中心安全培训，并且是安全委员会的成员。