Functional MRI Core Facility

功能性核磁共振核心设施

基本信息

批准号：
7735204
负责人：
Peter Bandettini
金额：
$ 286.49万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7735204
关键词：
Address Affect Agreement Americas Amygdaloid structure Anatomy Archives Arts Attention Basic Science Boxing Brain Brain Mapping Class Clinical Clinical Research Communication Communities Compatible Complement Computers Consult Cooperative Research and Development Agreement Core Facility Custom Daily Data Decision Making Depth Development Devices Dissociation Documentation Education Electronics Electrostatics Emotional Employee Ensure Environment Equipment Event Eye Eye Movements Face Feedback Fiber Optics Floor Focus Groups Functional Magnetic Resonance Imaging Genetic Variation Goals Heterogeneity Hippocampus (Brain)Hour Human Image Individual Institutes Joystick Lamivudine MRI Scans Magnetic Resonance Imaging Maintenance Measures Methods Mission Monitor National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Nature Neurosciences Noise Nonlinear Dynamics Operative Surgical Procedures Other Resources Outcome Participant Patients Peer Review Physiologic pulse Physiology Policies Primates Principal Investigator Procedures Process Protocols documentation Publications Publishing Pulse taking RF coil Research Research Ethics Committees Research Personnel Research Subjects Resolution Resources Rewards Risk Running Scanning Schedule Schizophrenia Science Scientist Services Signal Transduction Site Skin Specialist Spectrum Analysis Speed Standards of Weights and Measures Structure Support of Research System Techniques Technology Time Training Translating United States National Academy of Sciences United States National Institutes of Health Update Variant Week base blood oxygenation level dependent response clinically relevant day digital finesse fly in vivo neuroimaging nonhuman primate quality assurance relating to nervous system research study response serotonin transporter symposium tool

项目摘要

Space Utilization: The FMRIF currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, and 1.5T MRI scanners located within the NMR center and office space on the second floor above the NMR center in the FMRIF/SFIM suite (approximately 1400 sq ft total, including shared conference space). Staff: The FMRIF staff (currently 14 full time employees) consist of: the facility director, three staff scientists (fourth staff scientist is expected to join the group in February 2009), eight MRI technologists, an IT specialist, and an administrative lab manager. Core users: The functional MRI facility supports the research of about 30 Principle Investigators which translates to about 300 researchers overall. Approximately 70 active IRB protocols are active and making use of FMRIF scanners. Each scanner has scheduled operating hours of 105 hours per week. Since the year 2000 until Sep 2008 there were 380 peer reviewed publications published with data acquired on FMRIF MRI scanners and with facility assistance. High Impact Publications Resulting from MRI Usage: Beauchamp, M. S., Argall, B. D., Bodurka, J., Duyn, J. H., & Martin, A. (2004). Unraveling multisensory integration: patchy organization within human STS multisensory cortex. Nat Neuroscience, 2004, 7(5), 809-823. Birn, R. M., Saad, Z. S., & Bandettini, P. A. (2001). Spatial heterogeneity of the nonlinear dynamics in the FMRI BOLD response. NeuroImage, 14(4), 817-826. Callicott, J. H., Straub, R. E., Pezawas, L., Egan, M. F., Mattay, V. S., Hariri, A. R., et al. (2005). Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 102(24), 8627-8632. Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297(5580), 400-403. Heekeren, H. R., Marrett, S., Bandettini, P. A., & Ungerleider, L. G. (2004). A general mechanism for perceptual decision-making in the human brain. Nature, 431(7010), 859-862. Knutson, B., Fong, G. W., Adams, C. M., Varner, J. L., & Hommer, D. (2001). Dissociation of reward anticipation and outcome with event-related fMRI. NeuroReport, 12(17), 3683-3687. Meyer-Lindenberg, A., Ziemann, U., Hajak, G., Cohen, L., & Berman, K. F. (2002). Transitions between dynamical states of differing stability in the human brain. Proceedings of the National Academy of Sciences of the United States of America, 99(17), 10948-10953. Pessoa, L., McKenna, M., Gutierrez, E., & Ungerleider, L. G. (2002). Neural processing of emotional faces requires attention. Proceedings of the National Academy of Sciences of the United States of America, 99(17), 11458-11463. Rickard, T. C., Romero, S. G., Basso, G., Wharton, C., Flitman, S., & Grafman, J. (2000). The calculating brain: An fMRI study. Neuropsychologia, 38(3), 325-335. Accomplishments: The FMRIF completed a major renovation and equipment upgrade in 2007/2008 and now operates three General Electric 3T MRI scanners as well as one General Electric 1.5T MRI scanner. With these new systems our 3T scanning capacity increased approximately 50% (two 3T scanners in 2007 to three 3T scanners in Jan 2008). The new scanners are short-bore General Electric 3 Tesla MRI systems: one is equipped with 16 MRI signal receivers (or channels) and is also equipped for spectroscopy experiments, while the other has 32 channels which can be used for high-resolution functional brain mapping experiments. Both scanners are equipped with an array of RF coils or receivers which provide a state of the art scanning environment. The scanners are equipped with a full system for interfacing with research subjects, including video delivered using high-speed digital projectors and electrostatic audio systems that are MR compatible. These devices are complemented with MR compatible methods for measuring subject/patient physiology in the magnets as well as fiber-optic systems for providing subject feedback and infrared video systems for monitoring eye movements in the magnet. All FMRIF MRI scanners are available for research 14 hours a day and 7 days a week. To ensure high quality imaging data and to reduce scanner down time, advance daily quality assurance procedures have been developed. An additional development includes real-time fMRI capability. This also allows for conducting FMRI experiments involving neurofeedback to the subject. All imaging data are extracted from the MRI scanner, converted, and saved on the fly onto dedicated real-time and data server computers together with complete electronic documentation of all performed scans. In the past year, the functional MRI facility has established a primate imaging platform for anatomical and functional MRI studies of nonhuman primates. This involved the integration of a custom mounting device and coil in addition to a protocol that seamlessly allows the transition of use of the scanner for imaging primates at 1.5T and 3T. This has become a useful tool for those researchers in the NIH that would like to complement their human fMRI studies with primate studies. It should be mentioned that the 1.5T scanner has become the primary clinical research scanner, with the appropriate staff and equipment for studying patients who need additional attention. This utility has proven critically necessary for many protocols. Lastly, a major accomplishment of the core facility last year was in association with the renovations revolving around installation of the new 3T scanner. These renovations required one of our 3T scanners be shut down. Handling this renovation required adjusting the user schedule and establishing temporary time on a scanner owned by GE but set up at the NIH in accordance with a CRADA agreement. This required finesse on the part of the facility staff to manage this transfer. Most users were quite happy with how this was handled, as their research was not significantly interrupted.

空间利用率： FMRIF 目前占地约 4800 平方英尺，分为扫描仪隔间、控制室和电子/机械室，用于 3TA、3TB、3TC 和 1.5T MRI 扫描仪，位于 NMR 中心和二楼的办公空间内FMRIF/SFIM 套件中的 NMR 中心（总面积约 1400 平方英尺，包括共享会议空间）。职员： FMRIF 员工（目前有 14 名全职员工）包括：设施主任、三名科学家（第四名科学家预计于 2009 年 2 月加入该小组）、八名 MRI 技术专家、一名 IT 专家和一名实验室行政经理。核心用户：功能性 MRI 设施支持约 30 名主要研究人员的研究，相当于总共约 300 名研究人员。大约有 70 个活跃的 IRB 协议处于活跃状态并使用 FMRIF 扫描仪。每台扫描仪的预定运行时间为每周 105 小时。自 2000 年至 2008 年 9 月，共有 380 篇同行评审出版物发表，其中的数据是在 FMRIF MRI 扫描仪和设施协助下获取的。 MRI 使用产生的高影响力出版物： Beauchamp, M. S.、Argall, B. D.、Bodurka, J.、Duyn, J. H. 和 Martin, A. (2004)。解开多感觉整合：人类 STS 多感觉皮层内的不完整组织。自然神经科学，2004，7(5)，809-823。 Birn, R. M.、Saad, Z. S. 和 Bandettini, P. A. (2001)。 FMRI BOLD 响应中非线性动力学的空间异质性。神经影像，14(4), 817-826。 Callicott, J. H.、Straub, R. E.、Pezawas, L.、Egan, M. F.、Mattay, V. S.、Hariri, A. R. 等人。（2005）。 DISC1 的变异会影响海马结构和功能，并增加患精神分裂症的风险。美国国家科学院院刊，102(24), 8627-8632。 Hariri, A. R.、Mattay, V. S.、Tessitore, A.、Kolachana, B.、Fera, F.、Goldman, D. 等。（2002）。血清素转运蛋白遗传变异和人类杏仁核的反应。科学，297（5580），400-403。 Heekeren, H. R.、Marrett, S.、Bandettini, P. A. 和 Ungerleider, L. G. (2004)。人脑感知决策的一般机制。自然，431（7010），859-862。 Knutson, B.、Fong, G. W.、Adams, C. M.、Varner, J. L. 和 Hommer, D. (2001)。奖励预期和结果与事件相关功能磁共振成像的分离。神经报告，12（17），3683-3687。 Meyer-Lindenberg, A.、Ziemann, U.、Hajak, G.、Cohen, L. 和 Berman, K. F. (2002)。人脑中不同稳定性的动态状态之间的转换。美国国家科学院院刊，99(17), 10948-10953。 Pessoa, L.、McKenna, M.、Gutierrez, E. 和 Ungerleider, L. G. (2002)。情绪面孔的神经处理需要注意。美国国家科学院院刊，99(17), 11458-11463。 Rickard, T. C.、Romero, S. G.、Basso, G.、Wharton, C.、Flitman, S. 和 Grafman, J. (2000)。计算大脑：功能磁共振成像研究。神经心理学，38(3), 325-335。成就： FMRIF 在 2007/2008 年完成了重大改造和设备升级，现在运行三台通用电气 3T MRI 扫描仪和一台通用电气 1.5T MRI 扫描仪。借助这些新系统，我们的 3T 扫描能力增加了约 50%（2007 年的两台 3T 扫描仪到 2008 年 1 月增加了三台 3T 扫描仪）。新扫描仪是短口径通用电气3 Tesla MRI系统：一套配备16个MRI信号接收器（或通道），也配备用于光谱学实验，而另一套配备32个通道，可用于高分辨率功能性大脑测绘实验。两台扫描仪都配备了射频线圈或接收器阵列，可提供最先进的扫描环境。扫描仪配备了与研究对象连接的完整系统，包括使用高速数字投影仪传输的视频和与 MR 兼容的静电音频系统。这些设备还配有用于测量磁体中受试者/患者生理机能的 MR 兼容方法，以及用于提供受试者反馈的光纤系统和用于监测磁体中眼球运动的红外视频系统。所有 FMRIF MRI 扫描仪每周 7 天、每天 14 小时均可用于研究。为了确保高质量的成像数据并减少扫描仪停机时间，我们制定了先进的日常质量保证程序。另一项开发包括实时功能磁共振成像功能。这也允许进行涉及受试者神经反馈的 FMRI 实验。所有成像数据均从 MRI 扫描仪中提取、转换并即时保存到专用的实时数据服务器计算机上，以及所有执行扫描的完整电子文档。去年，功能性核磁共振设施建立了灵长类动物成像平台，用于非人类灵长类动物的解剖和功能性核磁共振研究。这涉及定制安装设备和线圈的集成，以及允许无缝过渡扫描仪在 1.5T 和 3T 下对灵长类动物成像的协议。对于 NIH 的研究人员来说，这已成为一个有用的工具，他们希望通过灵长类动物研究来补充他们的人类功能磁共振成像研究。值得一提的是，1.5T 扫描仪已成为主要的临床研究扫描仪，并配备了适当的人员和设备来研究需要额外关注的患者。事实证明，该实用程序对于许多协议至关重要。最后，去年核心设施的一项重大成就是围绕安装新 3T 扫描仪进行的翻修。这些改造需要关闭我们的一台 3T 扫描仪。处理这一改造需要调整用户时间表并在 GE 拥有但根据 CRADA 协议设置在 NIH 的扫描仪上建立临时时间。这需要设施工作人员巧妙地管理这次转移。大多数用户对处理方式非常满意，因为他们的研究没有受到明显干扰。