Development and validation of a smart harness to study babies with developmental dysplasia of the hip

开发和验证用于研究患有髋关节发育不良的婴儿的智能安全带

• 批准号: 10557616
• 负责人: Erin Mannen
• 金额: $ 19.26万
• 依托单位: BOISE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-06 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557616
• 关键词: 3-Dimensional; Agreement; Area; Avascular Necrosis of Femur Head; Biomechanics; Biometry; Birth; Caregivers; Centers of Research Excellence; Clinical; Clinical Research; Collection; Complication; Computer Analysis; Computer Models; Data; Data Collection; Data Reporting; Degenerative polyarthritis; Development; Devices; Disease; Dysplasia; Engineering; Equipment; Failure; Frequencies; Future; Goals; Hip Joint; Hip Osteoarthritis; Hip region structure; Home; Home environment; Hour; Human; Image; Industry Collaboration; Infant; Knowledge; Laboratories; Life; Manikins; Manuals; Measurement; Measures; Mechanics; Medical; Medical Device; Methods; Monitor; Motion; Movement; Operative Surgical Procedures; Outcome; Pain; Patient Self-Report; Population; Positioning Attribute; Recommendation; Research; Risk; Science; Shapes; Supination; Testing; Textiles; Time; Treatment Failure; Validation; Work; body position; cost; design; early onset; fabrication; femur head; flexibility; foot; human subject; improved; in vitro testing; in vivo; in vivo evaluation; manufacturing capabilities; pressure sensor; research study; sensor; success; tool

PROJECT SUMMARY – MANNEN Developmental dysplasia of the hip (DDH) is a mechanical disorder that impacts up to 10% of the population at birth, but given a lack of knowledge to inform research and treatment, can result in a lifetime of painful and costly biomechanical problems and osteoarthritis. Improving treatment depends on understanding how a baby interacts with the Pavlik harness mechanical therapy brace at home, yet no research tools exist that allow for such measurements. The purpose of this project is to develop and validate a “smart” harness to enable at home research relating to how babies being treated for DDH interact with the brace. We will (Aim 1) Develop sensors to measure biomechanics within the Pavlik harness, (Aim 2) Embed sensors onto the Pavlik harness and validate via in vitro testing, and (Aim 3) Validate the smart harness with in vivo human subjects testing. The smart harness developed in this study will provide a proof-of-concept research device on which we can design future research and clinical studies to monitor the wear time, body position, and kicking data of babies undergoing DDH treatment, resulting in a more thorough understanding of these modifiable factors on clinical success. This project fits within the overall COBRE theme by focusing on developing and embedding flexible sensors into a therapy device for biomedical applications. The Fabrication, Characterization, and Testing Research Core is critical to the success of this project. Specifically, I will use the advanced manufacturing capabilities and equipment to develop new flexible sensor types in Aim 1. The ElectroForce mechanical testing machine will be required to validate the kicking data from sensors in Aim 2. The 3D scanner will be required to develop computer models of the smart harness in Aim 3 and will be necessary for future computational analysis of the completed device.

项目摘要 - Mannen 髋关节发育发育不良（DDH）是一种机械疾病，可影响多达10％的人群 出生，但鉴于缺乏知识来告知研究和治疗，可能会导致一生的痛苦和 昂贵的生物力学问题和骨关节炎。改善治疗取决于了解婴儿的方式 与家里的帕夫利克线束机械疗法支架相互作用，但没有任何研究工具可以允许 这样的测量。该项目的目的是开发和验证“明智”的利用物以启用 关于如何治疗DDH的婴儿与支架相互作用的家庭研究。我们将（目标1）发展 传感器测量帕夫利克线束内的生物力学，（AIM 2）将传感器嵌入到帕夫利克安全带上 并通过体外测试来验证（AIM 3）通过体内人体受试者测试验证智能线束。 在本研究中开发的智能安全带将提供概念验证的研究设备 设计未来的研究和临床研究，以监视婴儿的磨损时间，身体位置和踢数据 接受DDH治疗，从而更彻底地了解这些可修改的因素 成功。通过专注于开发和嵌入灵活 传感器进入用于生物医学应用的治疗装置。制造，表征和测试 研究核心对于该项目的成功至关重要。具体来说，我将使用高级制造 在AIM 1中开发新的灵活传感器类型的功能和设备。电气机械测试 将需要机器在AIM 2中验证传感器的踢踢数据。将需要3D扫描仪才能 在AIM 3中开发智能安全带的计算机模型，对于将来的计算是必要的 分析已完成的设备。