K07 Preventive Oncology Academic Award

K07预防肿瘤学学术奖

基本信息

批准号：
7681318
负责人：
KALA VISVANATHAN
金额：
$ 14.01万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-30 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7681318
关键词：
Abbreviations Activities of Daily Living Adverse effects Anticarcinogenic Agents Award Biological Markers Biometry Breast Broccoli - dietary Brussels sprouts - dietary Cabbage - dietary Carcinogens Catechol Estrogens Cauliflower Chemicals Chemoprevention Chemopreventive Agent Clinical Oncology Clinical Research Clinical Trials Clinical Trials Design Complex Consumption Correlative Study DNA Data Development Disease Dose Dose-Limiting Drug Kinetics Edible Plants Educational process of instructing Ensure Environment Enzyme Induction Enzymes Epidemiology Epithelial Cells Estrogens Etiology Food Safety General Population Genes Genetic Predisposition to Disease Genomics Glucosinolates Glutathione S-Transferase Goals High Pressure Liquid Chromatography Human Hydrolysis Incidence Individual Intake Intervention Intervention Trial Intestines Isothiocyanates Knowledge Laboratory Finding Lead Malignant Neoplasms Mammary Gland Parenchyma Mammary Tumorigenesis Mammary gland Measures Mentorship Methylation Molecular Biology Morbidity - disease rate Myrosinase NAD(P)H dehydrogenase (quinone) 1, human NF-E2-related factor 2 NQO1 gene National Cancer Institute Operative Surgical Procedures Pattern Pharmacodynamics Pharmacology and Toxicology Phase Placebos Plants Preparation Preventive Process Proliferation Marker Proteomics Quinone Reductases Randomized Clinical Trials Randomized Controlled Clinical Trials Reactive Oxygen Species Relative Risks Research Research Infrastructure Research Personnel Risk Rodent Sampling Serum Staging Sulforaphane Tamoxifen Tea Testing Tissues Toxic effect Transferase Urine Water Woman Work aqueous cancer chemoprevention cancer prevention cancer risk carcinogenesis cruciferous vegetable design detoxication experience glucoraphanin high risk indexing inhibitor/antagonist interdisciplinary approach malignant breast neoplasm member metabolomics mortality neoplastic novel oncology preclinical study prevent skills symposium trial comparing

项目摘要

DESCRIPTION (provided by applicant): Effective control of a complex disease such as breast cancer requires a multidisciplinary approach that bridges the gap between the "why and what" of cancer causation and the "how" to prevent cancer incidence morbidity and mortality. This Preventive Oncology Academic Award will provide the candidate the opportunity to strengthen her skills in clinical trial design and biostatistics, develop her knowledge in molecular biology, pharmacology and toxicology and give her the necessary research experience to successfully integrate a multidisciplinary approach into the design of effective chemoprevention strategies. The candidate will attend courses offered at Johns Hopkins as well as the National Cancer Institute (NCI) focusing on clinical trial design and the use of biomarkers in epidemiological and clinical research. She will participate in conferences, rounds and seminars both in the Department of Epidemiology and in the Oncology Center. She will also engage in a limited amount of teaching and clinical oncology work relevant to her cancer prevention activities. In keeping with the candidates goal to become proficient in the design, conduct and analysis of intervention trials two clinical studies are proposed to examine the efficacy of an aqueous extract of broccoli sprout or "tea" (BST) as a chemopreventive agent for breast cancer. The first study evaluates the pharmacokinetics and pharmacodynamic action of broccoli sprouts tea in 30 healthy women undergoing breast reduction surgery by conducting a two-week dose-finding clinical trial that measures both phase 2 inducer activity and isothiocyanate metabolites in mammary tissue. In the second study, a phase II randomized trial design will be used to test whether a 3 months intervention of BST modulates a panel of specific tissue biomarkers of breast cancer risk compared to placebo, in 126 women at increased risk for breast cancer. Together these planned developmental experiences along with the supportive environment and research infrastructure of Johns Hopkins and the mentorship of Dr Kathy Helzsouer and Dr Nancy Davidson will ensure Dr Visvanathan's successful transition into an independent cancer prevention and control investigator with expertise in chemoprevention trials.

描述（由申请人提供）：有效控制乳腺癌等复杂疾病需要采取多学科方法，以弥合癌症病因的“原因和原因”与预防癌症发病率和死亡率“如何”之间的差距。该预防肿瘤学学术奖将为候选人提供机会，以加强她在临床试验设计和生物统计学方面的技能，发展她在分子生物学、药理学和毒理学方面的知识，并为她提供必要的研究经验，以成功地将多学科方法融入到有效的设计中。化学预防策略。候选人将参加约翰霍普金斯大学和国家癌症研究所 (NCI) 提供的课程，重点是临床试验设计以及生物标志物在流行病学和临床研究中的使用。她将参加流行病学系和肿瘤学中心的会议、查房和研讨会。她还将从事与癌症预防活动相关的有限教学和临床肿瘤学工作。为了与候选人精通干预试验的设计、实施和分析的目标保持一致，提出了两项临床研究来检验西兰花芽或“茶”水提取物（BST）作为乳腺癌化学预防剂的功效。第一项研究通过进行为期两周的剂量探索临床试验，测量乳腺组织中的 2 期诱导剂活性和异硫氰酸酯代谢物，评估西兰花芽茶在 30 名接受乳房缩小手术的健康女性中的药代动力学和药效学作用。在第二项研究中，将使用 II 期随机试验设计来测试 126 名乳腺癌风险较高的女性，与安慰剂相比，为期 3 个月的 BST 干预是否能调节一组乳腺癌风险的特定组织生物标志物。这些计划的发展经验以及约翰·霍普金斯大学的支持性环境和研究基础设施以及 Kathy Helzsouer 博士和 Nancy Davidson 博士的指导将确保 Visvanathan 博士成功转型为具有化学预防试验专业知识的独立癌症预防和控制研究者。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Diagnosis of serous tubal intraepithelial carcinoma based on morphologic and immunohistochemical features: a reproducibility study.

基于形态学和免疫组织化学特征的浆液性输卵管上皮内癌的诊断：重复性研究。

DOI：
发表时间：
2011-12
期刊：
影响因子：
0
作者：
Visvanathan, Kala;Vang, Russell;Shaw, Patricia;Gross, Amy;Soslow, Robert;Parkash, Vinita;Shih, Ie;Kurman, Robert J
通讯作者：
Kurman, Robert J

未产妇与已产妇女的激素相关危险因素和绝经后乳腺癌：一项综合研究。

DOI：
发表时间：
2011-03-01
期刊：
影响因子：
5
作者：
Schonfeld, Sara J;Pfeiffer, Ruth M;Lacey Jr, James V;Berrington de González, Amy;Doody, Michele M;Greenlee, Robert T;Park, Yikyung;Schairer, Catherine;Schatzkin, Arthur;Sigurdson, Alice J;Hartge, Patricia;Visvanathan, Kala
通讯作者：
Visvanathan, Kala

Genome-Wide Association Studies of Endometrial Cancer: Latest Developments and Future Directions.

子宫内膜癌的全基因组关联研究：最新进展和未来方向。

DOI：
发表时间：
2019
期刊：
影响因子：
0
作者：
O'Mara, Tracy A;Glubb, Dylan M;Kho, Pik Fang;Thompson, Deborah J;Spurdle, Amanda B
通讯作者：
Spurdle, Amanda B

Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer.

IL10 以及与炎症反应和肥胖相关的其他基因的常见多态性与结直肠癌的关联。

DOI：
发表时间：
2009-11
期刊：
影响因子：
0
作者：
Tsilidis, Konstantinos K;Helzlsouer, Kathy J;Smith, Michael W;Grinberg, Victoriya;Hoffman;Clipp, Sandra L;Visvanathan, Kala;Platz, Elizabeth A
通讯作者：
Platz, Elizabeth A

Gender-specific differences in birthweight and the odds of puberty: NHANES III, 1988-94.

出生体重和青春期几率的性别差异：NHANES III，1988-94。