Impact of Malaria Co-Infection on HIV-Associated Neurocognitive Disorders

疟疾合并感染对 HIV 相关神经认知障碍的影响

基本信息

  • 批准号:
    8234107
  • 负责人:
  • 金额:
    $ 17.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-03-15 至 2014-02-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Career Development Aim: To develop into an independent, productive clinical investigator focusing on patient-oriented research in the field of HIV and malaria neuropathogenesis. Career Development Methods: An individualized curriculum with focused training in clinical research methodology, tropical infectious diseases, NeuroAIDS research, and mentor/faculty interactions is proposed. Scientific Background: Malaria, a mosquito-borne parasitic disease, and HIV, a viral infection, are two disparate and deadly diseases that are often brought together by overlapping geographic distributions. Even though these pathogens frequently infect the same host, their combined effects on the brain are virtually uninvestigated. Since macrophages are centrally involved in both malaria and HIV pathogenesis, we hypothesize that both of these pathogens disrupt the cytokine network of brain macrophages, thereby contributing to the progression of HIV-associated neurologic disorders (HAND). Research Aim: To determine the impact of malaria co-infection on HIV-associated neurocognitive impairment (NCI). Research Methods: This study will be conducted in Chennai, India where both malaria and HIV are highly prevalent. Malaria co-infection will be detected using an innovative pooling strategy and a sensitive Polymerase Chain Reaction assay. NCI, measured by comprehensive neuropsychological (NP) testing, will be compared between HIV/malaria co-infected and HIV-monoinfected participants. In addition to measures of pathogen activity, a panel of inflammation-associated biomarkers (IAB) will be measured in blood. Changes in NP performance will be compared to changes in measures of pathogen activity and inflammation in the HIV/malaria co-infected group before and after malaria therapy. Combined, these results will identify, for the first time, the contribution of malaria to HIV-associated NCI and the impact of treating malaria. Significance: These studies will lead to - i) improvement in HIV/AIDS care through detection and treatment of malaria coinfection; ii) demonstrate the adverse effect of HIV/malaria co-infection on the brain; iii) stimulate further research in this field. The negative impact of undiagnosed malaria co-infection may justify PCR-related expenses in routine clinical care of HIV-infected individuals in malaria endemic regions of the world. The knowledge gained from this study will significantly improve the assessment, diagnosis, and hence treatment of HIV and malaria associated neurobehavioral deficits among adults. PUBLIC HEALTH RELEVANCE: The knowledge gained from this study will significantly improve the assessment, diagnosis, and hence treatment of HIV and malaria associated neurobehavioral deficits among adults.
描述(由申请人提供): 职业发展目标: 发展成为一名独立、富有成效的临床研究者,专注于艾滋病毒和疟疾神经发病机制领域以患者为导向的研究。职业发展方法:提出了个性化课程,重点培训临床研究方法、热带传染病、神经艾滋病研究和导师/教师互动。科学背景:疟疾(一种由蚊子传播的寄生虫病)和艾滋病毒(一种病毒感染)是两种截然不同的致命疾病,它们往往因重叠的地理分布而聚集在一起。尽管这些病原体经常感染同一宿主,但它们对大脑的综合影响实际上尚未得到研究。由于巨噬细胞主要参与疟疾和艾滋病毒的发病机制,我们假设这两种病原体都会破坏脑巨噬细胞的细胞因子网络,从而促进艾滋病毒相关神经系统疾病(HAND)的进展。研究目的:确定疟疾合并感染对 HIV 相关神经认知障碍 (NCI) 的影响。研究方法:这项研究将在印度钦奈进行,那里疟疾和艾滋病毒都非常流行。将使用创新的汇集策略和敏感的聚合酶链反应测定来检测疟疾合并感染。 NCI 通过综合神经心理学 (NP) 测试进行测量,将在 HIV/疟疾共同感染者和 HIV 单一感染者之间进行比较。除了测量病原体活性外,还将测量血液中的一组炎症相关生物标志物 (IAB)。将 NP 表现的变化与 HIV/疟疾共感染组在疟疾治疗前后病原体活性和炎症指标的变化进行比较。综合起来,这些结果将首次确定疟疾对艾滋病毒相关 NCI 的影响以及治疗疟疾的影响。意义:这些研究将导致 - i) 通过检测和治疗疟疾合并感染来改善艾滋病毒/艾滋病护理; ii) 证明艾滋病毒/疟疾混合感染对大脑的不利影响; iii) 促进该领域的进一步研究。未确诊的疟疾合并感染的负面影响可能证明在世界疟疾流行地区的艾滋病毒感染者的常规临床护理中与 PCR 相关的费用是合理的。从这项研究中获得的知识将显着改善成人中艾滋病毒和疟疾相关神经行为缺陷的评估、诊断和治疗。 公共卫生相关性:从这项研究中获得的知识将显着改善成人中艾滋病毒和疟疾相关神经行为缺陷的评估、诊断和治疗。

项目成果

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AJAY R BHARTI其他文献

AJAY R BHARTI的其他文献

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{{ truncateString('AJAY R BHARTI', 18)}}的其他基金

Impact of HCV Therapy on CNS Outcomes
HCV 治疗对 CNS 结果的影响
  • 批准号:
    9764315
  • 财政年份:
    2015
  • 资助金额:
    $ 17.05万
  • 项目类别:
Impact of HCV Therapy on CNS Outcomes
HCV 治疗对 CNS 结果的影响
  • 批准号:
    9283537
  • 财政年份:
    2015
  • 资助金额:
    $ 17.05万
  • 项目类别:
Impact of HCV Therapy on CNS Outcomes
HCV 治疗对 CNS 结果的影响
  • 批准号:
    8922577
  • 财政年份:
    2015
  • 资助金额:
    $ 17.05万
  • 项目类别:
Impact of Malaria Co-Infection on HIV-Associated Neurocognitive Disorders
疟疾合并感染对 HIV 相关神经认知障碍的影响
  • 批准号:
    8037059
  • 财政年份:
    2010
  • 资助金额:
    $ 17.05万
  • 项目类别:
Impact of Malaria Co-Infection on HIV-Associated Neurocognitive Disorders
疟疾合并感染对 HIV 相关神经认知障碍的影响
  • 批准号:
    8526559
  • 财政年份:
    2010
  • 资助金额:
    $ 17.05万
  • 项目类别:
Impact of Malaria Co-Infection on HIV-Associated Neurocognitive Disorders
疟疾合并感染对 HIV 相关神经认知障碍的影响
  • 批准号:
    7842301
  • 财政年份:
    2010
  • 资助金额:
    $ 17.05万
  • 项目类别:

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疟疾合并感染对 HIV 相关神经认知障碍的影响
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    8526559
  • 财政年份:
    2010
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    $ 17.05万
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Impact of Malaria Co-Infection on HIV-Associated Neurocognitive Disorders
疟疾合并感染对 HIV 相关神经认知障碍的影响
  • 批准号:
    7842301
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    2010
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Tat、β 淀粉样蛋白和脑内皮屏障功能
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