Aging and Physical Functioning in HIV

艾滋病毒的衰老和身体机能

基本信息

批准号：
7913496
负责人：
KRISANN K OURSLER
金额：
$ 5.4万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7913496
关键词：
Abbreviations Acquired Immunodeficiency Syndrome Activities of Daily Living Adult Adverse effects Advisory Committees Aerobic Aerobic Exercise Affect Age Age-Years Aging Baltimore Biology Biometry Board Certification CD4 Lymphocyte Count CD4 Positive T Lymphocytes Cardiomyopathies Cardiovascular system Chronic Disease Clinical Clinical Investigator Clinical Trials Code Cohort Studies Communicable Diseases Communities Comorbidity Complement component C1s Computers Control Groups Cross-Sectional Studies Cytochromes Data Diagnosis Disease Disease Progression Dual-Energy X-Ray Absorptiometry Education Effectiveness Elderly Electron Microscopy Enrollment Exercise Foundations Functional disorder Genes Geriatrics Gerontology Goals HIV HIV Infections HIV Seropositivity Healthcare Systems Highly Active Antiretroviral Therapy Histology Human immunodeficiency virus test ICD-9 Immune Immunologics Individual Infection Inflammatory Internal Medicine Intervention Jordan Justice Laboratories Life Longitudinal Studies Maryland Master of Science Medical Mentors Metabolic Methods Mitochondria Mitochondrial DNA Morbidity - disease rate Morphology Multicenter Trials Muscle Myopathy Myositis Nuclear Nucleosides Nurses Oxidases Oxygen Patients Performance Pharmaceutical Preparations Pharmacy facility Physical Function Physiology Prevention Protease Inhibitor Randomized Controlled Clinical Trials Reporting Research Research Personnel Research Proposals Reverse Transcriptase Inhibitors Roentgen Rays Site Skeletal Muscle Smoking Source Succinate Dehydrogenase Surveys Toxic effect Training Translations United States United States Department of Veterans Affairs Universities Veterans Viral Load result X-Ray Computed Tomography age effect age related antiretroviral therapy base career cohort design improved lifestyle factors medical schools mitochondrial oxidative dysfunction mortality multidisciplinary muscle form older patient patient oriented research patient population programs rehabilitation strategy sarcopenia sedentary tomography treatment strategy uptake wasting

项目摘要

DESCRIPTION (provided by applicant): The candidate is a promising young investigator with board certifications in Internal Medicine and Infectious Disease, and a Masters of Science degree in Clinical Investigation, who has made a substantial commitment to an academic career in patient-oriented research in aging and HIV. The career plan and research proposal are consistent with her long-term goal to become an independent clinical investigator, and leader in academic geriatric medicine and HIV. Older individuals represent an increasingly larger proportion of adults living with HIV infection in the United States. Reduced aerobic capacity, mitochondrial oxidative dysfunction and loss of lean muscle mass are problems that affect both HIV-infected and non-infected older adults. However sarcopenia and oxidative dysfunction may be more pronounced in the presence of HIV, with the deficits further compounded by the metabolic effects of antiretroviral therapy. Understanding the underlying mechanisms of limited functional performance in older HIV adults will allow us to design effective prevention and treatment strategies that will improve and preserve function in this rapidly growing older patient population. The objective of this proposal is to investigate the mechanisms by which aging affects physical functioning and aerobic capacity in HIV adults (AIM 1), and to determine if aerobic exercise training improves functional and cardiovascular performance in older HIV adults (AIM 2). Hypothesis #1. Reduced physical functioning with aging will be affected by baseline immune status in HIV adults, and will be similarly affected by medical comorbid conditions in HIV-infected vs. negative adults. Hypothesis #2. Skeletal muscle oxidative dysfunction is a central factor associated with reduced aerobic capacity and functional limitations in older HIV adults. Hypothesis #3. Aerobic exercise training will improve muscle oxidative dysfunction, and the associated functional limitations and reduced aerobic capacity in older HIV subjects compared to sedentary older HIV controls; however, improvements may be limited by the extent of sarcopenia and HIV-related myopathy. The proposed research will lay the foundation for subsequent studies that will investigate the optimal exercise-based rehabilitation strategies and the mechanisms by which they improve physical functioning in older HIV adults, and methods for their translation into community sites.

描述（由申请人提供）：候选人是一位有前途的年轻研究者，拥有内科和传染病委员会认证，以及临床研究理学硕士学位，他在以患者为导向的研究领域做出了重大学术生涯老龄化和艾滋病毒。职业规划和研究计划与她成为独立临床研究者以及老年医学和艾滋病毒学术领导者的长期目标一致。在美国，老年人感染艾滋病毒的比例越来越大。有氧能力下降、线粒体氧化功能障碍和瘦肌肉质量损失是影响艾滋病毒感染者和未感染者的老年人的问题。然而，在艾滋病毒存在的情况下，肌肉减少症和氧化功能障碍可能更加明显，抗逆转录病毒治疗的代谢作用进一步加剧了这些缺陷。了解老年艾滋病毒成人功能受限的根本机制将使我们能够设计有效的预防和治疗策略，以改善和保持这一快速增长的老年患者群体的功能。该提案的目的是调查衰老影响艾滋病毒成人身体功能和有氧能力的机制（AIM 1），并确定有氧运动训练是否可以改善老年艾滋病毒成人的功能和心血管表现（AIM 2）。假设#1。随着年龄的增长，身体机能下降将受到艾滋病毒成人基线免疫状态的影响，并且同样会受到艾滋病毒感染者与阴性成人的医疗共病的影响。假设#2。骨骼肌氧化功能障碍是与老年艾滋病毒成人有氧能力降低和功能限制相关的核心因素。假设#3。与久坐的老年艾滋病毒对照相比，有氧运动训练将改善老年艾滋病毒受试者的肌肉氧化功能障碍以及相关的功能限制和有氧能力下降；然而，改善可能会受到肌肉减少症和艾滋病毒相关肌病的程度的限制。拟议的研究将为后续研究奠定基础，这些研究将调查最佳的基于运动的康复策略及其改善老年艾滋病毒成人身体机能的机制，以及将其转化为社区场所的方法。