THE BREAST AND OVARIAN SURVEILLANCE SERVICE (BOSS) COHORT STUDY

乳房和卵巢监测服务 (BOSS) 队列研究

• 批准号: 7604640
• 负责人: KALA VISVANATHAN
• 金额: $ 0.76万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604640
• 关键词: Blood; Breast; Chemoprevention; Clinic; Clinical; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Early Diagnosis; End Point; Etiology; Family; Family history of; Funding; Future; General Population; Goals; Grant; Institution; Link; Malignant neoplasm of ovary; Measures; Medical Surveillance; Molecular Genetics; Ovarian; Pathway interactions; Phase; Population; Prevention strategy; Preventive; Research; Research Personnel; Resources; Risk; Risk Factors; Serum; Services; Source; Techniques; Thinking; Translations; United States National Institutes of Health; Woman; Women' s Group; base; breast density; breast lesion; cancer risk; case control; cohort; design; malignant breast neoplasm; modifiable risk; novel; outcome forecast

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary aim of this study is to establish a cohort of women with a family history of breast cancer so as to facilitate the translation of early detection techniques from the lab to the clinical setting. Twenty percent of women in the general population have a positive family history of breast cancer(1). Women at an increased risk of cancer are not well represented in population-based cohorts. The management options for both early detection and preventive strategies particularly in these families are extremely limited. This cohort would provide us with a platform to examine the association between novel genetic, molecular, and environmental markers/exposures, and both increased breast cancer and factors such as increased breast density that may be in the breast causal pathway using a case-control design (2). Over the long term we will be able to also measure factors associated with prognosis. Little is known about the etiology of breast density, which is prevalent in women with a family history of breast cancer and is a modifiable risk factor (2-5). Even if it is not causally linked, a decrease in breast density can increase the sensitivity of mammographic detection of early breast lesions, a useful goal in itself. Currently it is being used as an intermediate endpoint in phase II chemoprevention studies. Results from studies arising from this cohort may assist us in identifying factors that along with family history may modify a women risk of increased breast density and breast cancer. Factors that are thought to be in the causal pathway may then be able to be targeted with preventive agents. A secondary aim of this study is to collect blood and risk factor information on women with a family history of ovarian cancer for future studies. Some of these women will also have a family history of breast cancer and come to the high-risk clinic. Therefore, this is an opportunity for us to establish a serum bank in a rare group of women who are also in need of better predictive markers as well as early detection and preventive strategies.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究的主要目的是建立一个有乳腺癌家族史的女性队列，以促进早期检测技术从实验室到临床的转化。总人口中 20% 的女性有乳腺癌阳性家族史(1)。在基于人群的队列中，患癌症风险较高的女性并没有得到很好的代表。尤其是在这些家庭中，早期发现和预防策略的管理选择极其有限。 该队列将为我们提供一个平台，利用病例对照设计来检查新的遗传、分子和环境标志物/暴露与乳腺癌增加和乳腺密度增加等可能存在于乳腺因果途径中的因素之间的关联。 （2）。从长远来看，我们还能够测量与预后相关的因素。 关于乳腺密度的病因知之甚少，乳腺密度在有乳腺癌家族史的女性中普遍存在，并且是一个可改变的危险因素 (2-5)。即使没有因果关系，乳腺密度的降低也可以提高乳房X线照相检测早期乳腺病变的灵敏度，这本身就是一个有用的目标。目前它被用作 II 期化学预防研究的中间终点。 该队列的研究结果可能有助于我们确定与家族史一起可能改变女性乳腺密度增加和乳腺癌风险的因素。然后，预防性药物就可以针对被认为存在因果途径的因素。 这项研究的第二个目的是收集有卵巢癌家族史的女性的血液和危险因素信息，以供未来研究之用。其中一些女性还会有乳腺癌家族史，来到高危诊所就诊。因此，这是我们为少数女性建立血清库的机会，这些女性也需要更好的预测标记以及早期检测和预防策略。