Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Scientific and Data Coordinating Center

下尿路症状预防 (PLUS) 研究联盟科学和数据协调中心

• 批准号: 10249329
• 负责人: BERNARD L HARLOW
• 金额: $ 231.56万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10249329
• 关键词: Address; Adolescence; Adopted; Advocate; Affect; Athletic; Attitude; Award; Behavior; Belief; Biology; Biometry; Biostatistical Methods; Bladder; Clinical; Collaborations; Communities; Community Developments; Community Networks; Data; Data Analyses; Data Collection; Data Coordinating Center; Development; Device or Instrument Development; Disease; Enuresis; Environment; Ethics; Evaluation; Feasibility Studies; Fostering; Future; Goals; Grant; Health; Health Status; Housing; Intervention; Knowledge; Lead; Leadership; Life Cycle Stages; Logistics; Longevity; Longitudinal cohort study; Measurement; Measures; Modeling; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Observational Study; Pain; Pathology; Perception; Persons; Phase; Pilot Projects; Positioning Attribute; Prevention; Prevention strategy; Primary Prevention; Process; Psychometrics; Quality of life; Research; Research Personnel; Review Literature; Risk Factors; Role; Science; Secondary Prevention; Site; Social Interaction; Societies; Source; Stress Urinary Incontinence; Symptoms; Techniques; Testing; Time; Treatment Efficacy; Update; Urethra; Urinary Incontinence; Urinary tract infection; Urination; Woman; Work; aged; base; bedwetting; biopsychosocial; biopsychosocial factor; clinical care; data management; design; epidemiology study; evidence base; experience; girls; human old age (65+); innovation; instrument; lower urinary tract symptoms; meetings; member; men; modifiable risk; novel; population based; prevent; programs; prospective; protective factors; research study; urologic; web site

Project Summary Lower urinary tract symptoms (LUTS) encompass a variety of bothersome storage and emptying symptoms, including urgency and stress urinary incontinence, frequent and/or urgent urination, nocturnal enuresis (i.e., bed-wetting), difficulty urinating, dribbling after urination, and bladder or urethral pain before, during, or after urination. More than 200 million people worldwide and over 15% of women aged 40 years or older suffer from urinary incontinence. In fact, women are 2-3 times more likely to experience urinary incontinence and 4 times more likely to experience a urinary tract infection in comparison to men. For decades LUTS research has focused on underlying pathology, disease mechanisms, and treatment efficacy. The NIDDK took a bold step by introducing the concept of prevention as an important priority for women's urologic research. Through its transdisciplinary team science approach, the Prevention of Lower Urinary tract Symptoms Research Consortium (PLUS-RC) is creating new conceptual models and paradigms, developing innovative measures, establishing evidence, and leading and seeding research on bladder health and LUTS prevention. As the Scientific and Data Coordinating Center (SDCC) for this unique consortium since its inception, we are excited to further develop the evidence base to empower women and their communities to advocate for an environment that supports healthy bladders. During this next grant period, we plan to (1) provide leadership, management, and biostatistical support in the design and implementation of a nationally and regionally representative prospective longitudinal cohort study to assess the distribution of bladder health and evaluate potential risk and protective factors that influence bladder health status; (2) provide leadership, management, and biostatistical support in the analysis of existing studies (quantitative and qualitative) that will lead to the collaborative development of conceptual models that guide analyses within the observational study above, and new studies that support future primary or secondary prevention initiatives; (3) provide leadership in the principles and process devoted to item development, instrument development, and psychometric evaluation and scoring; (4) facilitate a network of community stakeholders to assist and collaborate in the process of data collection development, execution, and dissemination; (5) foster transdisciplinary team science across all consortium activities and centers; and (6) provide administrative leadership and logistical support and coordination of meetings of the Steering Committee, all subcommittees, the Executive Committee, the External Expert Panel, and the pilot and feasibility studies program, for the efficient and ethical execution of consortium objectives.

项目摘要 较低的尿路症状（LUTS）包括各种麻烦的储存和排空症状， 包括紧迫性和压力性尿失禁，频繁和/或紧急排尿，夜间尿液（即 卧床润湿），排尿困难，排尿后运球以及膀胱或尿道疼痛之前，之中或之后 排尿。全世界有超过2亿人，超过15％的40岁或40岁以上的妇女患有 尿失禁。实际上，妇女出现尿失禁的可能性高2-3倍 与男性相比，更有可能经历尿路感染。几十年来，LUTS研究一直 专注于潜在的病理，疾病机制和治疗效果。 Niddk迈出了大胆的一步 将预防概念介绍为妇女泌尿科研究的重要优先事项。 通过其跨学科团队科学方法，预防较低的尿路症状 研究联盟（Plus-RC）正在创建新的概念模型和范式，开发创新的 衡量，建立证据，领导和播种研究，以预防膀胱健康和LUTS。 自成立以来，作为该独特财团的科学和数据协调中心（SDCC），我们是 兴奋地进一步发展证据基础，以赋予妇女及其社区的能力 支持健康膀胱的环境。 在下一个赠款期间，我们计划（1）在 全国和地区代表性的前瞻性纵向队列研究的设计和实施 评估膀胱健康的分布并评估影响的潜在风险和保护因素 膀胱健康状况； （2）在分析现有的领导，管理和生物统计学支持 研究（定量和定性）将导致概念模型的协作发展 上述观测研究中的指南分析以及支持未来初级或次级的新研究 预防计划； （3）在专门用于项目开发的原则和过程中提供领导 仪器开发以及心理测量评估和评分； （4）促进社区网络 利益相关者协助和合作在数据收集开发，执行和 传播； （5）在所有财团和中心培养跨学科的团队科学； （6） 提供行政领导和后勤支持以及转向会议的协调 委员会，所有小组委员会，执行委员会，外部专家小组以及飞行员和 可行性研究计划，旨在有效和道德的财团目标执行。