Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Scientific and Data Coordinating Center

下尿路症状预防 (PLUS) 研究联盟科学和数据协调中心

基本信息

批准号：
10053401
负责人：
BERNARD L HARLOW
金额：
$ 200万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10053401
关键词：
Address Adolescence Adopted Advocate Affect Age Athletic Attitude Award Behavior Belief Biology Biometry Biostatistical Methods Bladder Clinical Collaborations Communities Community Developments Community Networks Data Data Analyses Data Collection Data Coordinating Center Development Device or Instrument Development Disease Enuresis Environment Ethics Evaluation Feasibility Studies Fostering Future Goals Grant Health Health Status Housing Intervention Knowledge Lead Leadership Life Cycle Stages Logistics Longevity Longitudinal cohort study Measurement Measures Modeling Monitor National Institute of Diabetes and Digestive and Kidney Diseases Observational Study Pain Pathology Perception Persons Phase Pilot Projects Positioning Attribute Prevention Prevention strategy Preventive Intervention Primary Prevention Process Psychometrics Quality of life Research Research Personnel Review Literature Risk Factors Role Science Secondary Prevention Site Social Interaction Societies Source Stress Urinary Incontinence Symptoms Techniques Testing Time Treatment Efficacy Update Urethra Urinary Incontinence Urinary tract infection Urination Woman Work aged base bedwetting biopsychosocial clinical care data management design dissemination research epidemiology study evidence base experience girls innovation instrument lower urinary tract symptoms meetings member men modifiable risk novel population based prevent programs prospective protective factors research study urologic web site

项目摘要

Project Summary Lower urinary tract symptoms (LUTS) encompass a variety of bothersome storage and emptying symptoms, including urgency and stress urinary incontinence, frequent and/or urgent urination, nocturnal enuresis (i.e., bed-wetting), difficulty urinating, dribbling after urination, and bladder or urethral pain before, during, or after urination. More than 200 million people worldwide and over 15% of women aged 40 years or older suffer from urinary incontinence. In fact, women are 2-3 times more likely to experience urinary incontinence and 4 times more likely to experience a urinary tract infection in comparison to men. For decades LUTS research has focused on underlying pathology, disease mechanisms, and treatment efficacy. The NIDDK took a bold step by introducing the concept of prevention as an important priority for women's urologic research. Through its transdisciplinary team science approach, the Prevention of Lower Urinary tract Symptoms Research Consortium (PLUS-RC) is creating new conceptual models and paradigms, developing innovative measures, establishing evidence, and leading and seeding research on bladder health and LUTS prevention. As the Scientific and Data Coordinating Center (SDCC) for this unique consortium since its inception, we are excited to further develop the evidence base to empower women and their communities to advocate for an environment that supports healthy bladders. During this next grant period, we plan to (1) provide leadership, management, and biostatistical support in the design and implementation of a nationally and regionally representative prospective longitudinal cohort study to assess the distribution of bladder health and evaluate potential risk and protective factors that influence bladder health status; (2) provide leadership, management, and biostatistical support in the analysis of existing studies (quantitative and qualitative) that will lead to the collaborative development of conceptual models that guide analyses within the observational study above, and new studies that support future primary or secondary prevention initiatives; (3) provide leadership in the principles and process devoted to item development, instrument development, and psychometric evaluation and scoring; (4) facilitate a network of community stakeholders to assist and collaborate in the process of data collection development, execution, and dissemination; (5) foster transdisciplinary team science across all consortium activities and centers; and (6) provide administrative leadership and logistical support and coordination of meetings of the Steering Committee, all subcommittees, the Executive Committee, the External Expert Panel, and the pilot and feasibility studies program, for the efficient and ethical execution of consortium objectives.

项目概要下尿路症状 (LUTS) 包括各种令人烦恼的储存和排空症状，包括尿急和压力性尿失禁、尿频和/或尿急、夜间遗尿（即尿床）、排尿困难、排尿后滴尿，以及尿前、尿中或尿后膀胱或尿道疼痛排尿。全球有超过 2 亿人，其中超过 15% 的 40 岁及以上女性患有此病尿失禁。事实上，女性出现尿失禁的可能性是女性的 2-3 倍，女性出现尿失禁的可能性是女性的 4 倍。与男性相比，更容易发生尿路感染。几十年来，LUTS 研究已经重点关注潜在病理学、疾病机制和治疗效果。 NIDDK 迈出了大胆的一步引入预防概念作为女性泌尿外科研究的重要优先事项。通过跨学科团队科学方法，预防下尿路症状研究联盟（PLUS-RC）正在创建新的概念模型和范式，开发创新措施、建立证据、领导和播种有关膀胱健康和 LUTS 预防的研究。作为这个独特联盟自成立以来的科学和数据协调中心 (SDCC)，我们很高兴能够进一步发展证据基础，赋予妇女及其社区权力，倡导支持膀胱健康的环境。在下一个资助期内，我们计划 (1) 在以下领域提供领导、管理和生物统计支持：设计和实施一项具有全国和地区代表性的前瞻性纵向队列研究评估膀胱健康的分布并评估影响的潜在风险和保护因素膀胱健康状况； (2) 在现有的分析中提供领导、管理和生物统计支持研究（定量和定性）将导致概念模型的协作开发指导上述观察性研究中的分析，以及支持未来小学或中学的新研究预防举措； (3) 领导项目开发的原则和流程，仪器开发、心理测量评估和评分； (4) 促进社区网络利益相关者在数据收集开发、执行和过程中提供协助和协作传播； (5) 在所有联盟活动和中心中促进跨学科团队科学；和（6）提供行政领导和后勤支持以及指导会议的协调委员会、所有小组委员会、执行委员会、外部专家小组以及试点和可行性研究计划，用于高效且合乎道德地执行联盟目标。