Prevention of Lower Urinary Tract Symptoms in Women: Bladder Health Scientific and Data Coordinating Center (PLUS-SDCC) (U01)

预防女性下尿路症状：膀胱健康科学和数据协调中心 (PLUS-SDCC) (U01)

• 批准号: 9981968
• 负责人: BERNARD L HARLOW
• 金额: $ 27.39万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9981968
• 关键词: Address; Adolescence; Affect; Age; Ancillary Study; Athletic; Behavior Therapy; Behavioral; Biological; Biological Factors; Biometry; Biostatistical Methods; Bladder; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Conceptual Domain; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Set; Development; Diagnosis; Disease; Education; Environment; Environmental Risk Factor; Epidemiology; Ethics; Future; Goals; Health; Health behavior; Incontinence; Infection; Inflammation; Infrastructure; Intervention; Intervention Studies; Knowledge; Lead; Leadership; Logistics; Longevity; Lower urinary tract; Meta-Analysis; Minnesota; Mission; Modeling; Monitor; Multi-Institutional Clinical Trial; Multicenter Studies; National Institute of Diabetes and Digestive and Kidney Diseases; Pain; Pelvic Inflammatory Disease; Pelvis; Positioning Attribute; Prevention; Preventive Intervention; Process; Productivity; Publications; Quality of life; Questionnaires; Randomized Controlled Trials; Recording of previous events; Research; Research Design; Research Personnel; Resources; Review Literature; Risk; Risk Factors; Science; Series; Site; Social Interaction; Source; Specimen; Structure; Symptoms; Techniques; Testing; Translating; Treatment Efficacy; Universities; Woman; Women' s Health; Work; base; biopsychosocial; clinical care; data management; data warehouse; design; dissemination research; epidemiology study; experience; flexibility; indexing; innovation; inter-institutional; lower urinary tract symptoms; meetings; member; modifiable risk; novel; population based; prevent; programs; protective factors; psychological distress; public health relevance; repository; research data dissemination; research study; skills; symposium

 DESCRIPTION (provided by applicant): Lower urinary tract symptoms (LUTS) in women are a source of illness, pain, and embarrassment, which can affect work, social interactions, and athletic and recreational activities in women from adolescence to old age. Almost 50% of women will experience LUTS at some point in their lifetime. Symptoms are harmful enough in themselves, but untreated, they can lead to more serious problems such as incontinence, infections, pelvic inflammation and psychological distress. The NIDDK program on Prevention of Lower Urinary tract Symptoms in women Research Consortium (PLUS-RC) is intended to broadly identify and evaluate the relative importance of the risk and protective factors for LUTS by conducting the necessary research studies to establish the scientific basis for future prevention intervention studies for lower urinary tract symptoms and conditions in women. Knowledge of such risk factors can lead to interventional strategies, which may be testable in future clinical trials. Specific aims of the PLUS-RC Scientific and Data Coordinating Center (SDCC) are to (1) conduct reviews of literature and meta-analyses of previous publications; (2) with the other PLUS-RC investigators, plan, design, and prioritize new epidemiologic and clinical studies of LUTS and implement an ancillary studies program; (3) provide data coordination and monitoring capabilities in support of PLUS-RC research studies; (4) provide comprehensive and innovative data analyses in support of presentation and publication of results, and construct high-quality datasets, which will be available to other researchers; and (5) provide logistical support for meetings and conference calls of the Steering and Planning Committee, all subcommittees, and an External Expert Panel for the efficient and ethical execution of consortium objectives. We bring together a uniquely strong team with a long history of accomplishment in biostatistics, epidemiology, and the conduct of large multi-center studies, extensive expertise in meta-analysis, observational data analysis, epidemiology specifically related to women's health, skills in behavioral modification and prevention science, and clinical care experience in the diagnosis and treatment of LUTS in women.

 描述：女性的尿路症状较低，是疾病，疼痛，会影响RK，社交互动，运动和娱乐活动，从青春期到老年人。 l寿命。 LUT的因素通过必要的研究依靠科学研究，用于未来生产研究的妇女症状和降低症状的因素。 - 先前的出版物； （5）为指导和计划委员会的仪器和会议提供后勤支持，所有小组委员会都汇集了漫长的成就，流行病学的历史，以及大型多中心研究的结合观察数据分析，流行病学与妇女的健康特别相关。