Prevention of Lower Urinary Tract Symptoms in Women: Bladder Health Scientific and Data Coordinating Center (PLUS-SDCC) (U01)

预防女性下尿路症状：膀胱健康科学和数据协调中心 (PLUS-SDCC) (U01)

• 批准号: 9755414
• 负责人: BERNARD L HARLOW
• 金额: $ 146.55万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9755414
• 关键词: Address; Adolescence; Affect; Age; Ancillary Study; Athletic; Behavior Therapy; Behavioral; Biological; Biological Factors; Biometry; Biostatistical Methods; Bladder; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Conceptual Domain; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Set; Development; Diagnosis; Disease; Education; Environment; Environmental Risk Factor; Epidemiology; Ethics; Future; Goals; Health; Health behavior; Incontinence; Infection; Inflammation; Infrastructure; Intervention; Intervention Studies; Knowledge; Lead; Leadership; Logistics; Longevity; Lower urinary tract; Meta-Analysis; Minnesota; Mission; Modeling; Monitor; Multi-Institutional Clinical Trial; Multicenter Studies; National Institute of Diabetes and Digestive and Kidney Diseases; Pain; Pelvic Inflammatory Disease; Pelvis; Positioning Attribute; Prevention; Preventive Intervention; Process; Productivity; Publications; Quality of life; Questionnaires; Randomized Controlled Trials; Recording of previous events; Research; Research Design; Research Personnel; Resources; Review Literature; Risk; Risk Factors; Science; Series; Site; Social Interaction; Source; Specimen; Structure; Symptoms; Techniques; Testing; Translating; Treatment Efficacy; Universities; Woman; Women' s Health; Work; base; biopsychosocial; clinical care; data management; data warehouse; design; dissemination research; epidemiology study; experience; flexibility; indexing; innovation; inter-institutional; lower urinary tract symptoms; meetings; member; modifiable risk; novel; population based; prevent; programs; protective factors; psychological distress; public health relevance; repository; research data dissemination; research study; skills; symposium

 DESCRIPTION (provided by applicant): Lower urinary tract symptoms (LUTS) in women are a source of illness, pain, and embarrassment, which can affect work, social interactions, and athletic and recreational activities in women from adolescence to old age. Almost 50% of women will experience LUTS at some point in their lifetime. Symptoms are harmful enough in themselves, but untreated, they can lead to more serious problems such as incontinence, infections, pelvic inflammation and psychological distress. The NIDDK program on Prevention of Lower Urinary tract Symptoms in women Research Consortium (PLUS-RC) is intended to broadly identify and evaluate the relative importance of the risk and protective factors for LUTS by conducting the necessary research studies to establish the scientific basis for future prevention intervention studies for lower urinary tract symptoms and conditions in women. Knowledge of such risk factors can lead to interventional strategies, which may be testable in future clinical trials. Specific aims of the PLUS-RC Scientific and Data Coordinating Center (SDCC) are to (1) conduct reviews of literature and meta-analyses of previous publications; (2) with the other PLUS-RC investigators, plan, design, and prioritize new epidemiologic and clinical studies of LUTS and implement an ancillary studies program; (3) provide data coordination and monitoring capabilities in support of PLUS-RC research studies; (4) provide comprehensive and innovative data analyses in support of presentation and publication of results, and construct high-quality datasets, which will be available to other researchers; and (5) provide logistical support for meetings and conference calls of the Steering and Planning Committee, all subcommittees, and an External Expert Panel for the efficient and ethical execution of consortium objectives. We bring together a uniquely strong team with a long history of accomplishment in biostatistics, epidemiology, and the conduct of large multi-center studies, extensive expertise in meta-analysis, observational data analysis, epidemiology specifically related to women's health, skills in behavioral modification and prevention science, and clinical care experience in the diagnosis and treatment of LUTS in women.

 描述（由适用提供）：女性较低的尿路症状（LUTS）是疾病，疼痛和尴尬的来源，可能会影响从青春期到老年的女性的工作，社交互动以及运动和娱乐活动。几乎50％的女性在一生中的某个时候会经历LUTS。症状本身足够有害，但未经治疗，它们可能导致更严重的问题，例如尿失禁，感染，骨盆感染和心理困扰。 NIDDK预防女性研究联盟（Plus-RC）中预防较低尿路症状的计划旨在通过进行必要的研究来广泛识别和评估LUT的风险和受保护因素的相对重要性，以建立对未来预防干预研究的科学依据，以确定妇女中较低尿中的尿液区域符号和状况。对此类危险因素的了解可能会导致介入策略，这可能在以后的临床试验中进行测试。加上RC科学和数据协调中心（SDCC）的具体目的是（1）对先前出版物的文献和荟萃分析进行审查； （2）与其他Plus-RC研究者一起计划，设计并确定了LUTS的新流行病学和临床研究，并实施辅助研究计划； （3）提供数据协调和监测功能，以支持加上RC研究； （4）提供全面和创新的数据分析，以支持结果的呈现和发布，并构建高质量的数据集，这些数据集将向其他研究人员使用； （5）为指导和计划委员会的会议和会议提供后勤支持，所有小组委员会，以及一个外部专家小组，以高效和道德的财产目标执行。我们汇集了一个独特的强大团队，具有悠久的生物统计学，流行病学成就的历史，以及大型多中心研究的进行，荟萃分析方面的广泛专业知识，观察数据分析，流行病学，与妇女的健康，行为修改和预防科学方面的技能特别相关的流行病学，以及在诊断和治疗女性方面的临床护理经验。