The Neural Basis of the Brain-Body Connection

脑与身体连接的神经基础

• 批准号: 10238817
• 负责人: Peter Strick
• 金额: $ 116.88万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-10 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10238817
• 关键词: Adrenal Glands; Affect; Affective; Anxiety; Area; Awareness; Back; Basic Science; Blood Pressure; Brain; Brain Stem; Cardiovascular system; Cerebral cortex; Cognition; Cognitive; Complex; Data; Development; Digestion; Disease; Endocrine; Exercise; Fibromyalgia; Foundations; Functional disorder; General Population; Generations; Goals; Heart; Heart Diseases; Housing; Human; Human Resources; Hypothalamic structure; Immune system; Immunity; Immunohistochemistry; Infrastructure; Institutes; Interneurons; Irritable Bowel Syndrome; Kidney; Knowledge; Label; Laboratories; Link; Medical; Meditation; Mental Depression; Methods; Mind; Modern Medicine; Monkeys; Motor; Nature; Neuraxis; Neuroanatomy; Neurons; Neurosciences Research; Operative Surgical Procedures; Organ; Output; Pathology; Pathway interactions; Play; Presynaptic Terminals; Process; Psychophysiologic Disorders; Rabies virus; Reptiles; Research; Research Personnel; Role; Signal Transduction; Site; Source; Spleen; Stomach; Stress; Structure; Symptoms; Synapses; System; Techniques; Testing; Time; Tracer; Training; United States National Institutes of Health; Vaccinated; Virus; Work; base; body system; connectome; emotional factor; experience; experimental study; gastrointestinal function; gastrointestinal system; innovation; interest; neural circuit; neural network; neuronal cell body; neurotropic virus; nonhuman primate; novel strategies; programs; relating to nervous system; restraint

We know almost nothing about the neural basis of the Brain-Body connection. This connection is the circuitry that enables motor, cognitive and affective processing to have a major impact on the function of internal organs such as the stomach, heart and spleen. Inappropriate signals in these networks are thought to contribute to the generation of some prevalent medical illnesses, and to cause the so-called "functional" and psychosomatic disorders. The experiments proposed in this application will fill a major gap in our knowledge. We will identify the cortical areas that influence, and in some instances control the function of the gastrointestinal (GI), cardiovascular and immune systems. The brain-body connection is based on chains of synaptically-connected neurons. No conventional neuroanatomical tracer is capable of revealing multi-synaptic circuits. To overcome this shortcoming, we developed the use of rabies virus as a transneuronal tracer in non-human primates. We propose to use this unique approach to reveal the complex networks that are responsible for the top-down influence of the central nervous system on the stomach, heart and spleen. There is a growing awareness that many medical symptoms, especially those without identifiable pathology, may be caused by a disturbance in the brain-body connection. This is especially the case for often intractable disorders such as irritable bowel syndrome, stress- and depression-related heart disease, and fibromyalgia. Thus, the information that will come from our studies has the potential to transform the way we view and treat these disorders. In essence, the brain-body connection is a construct that lacks a concrete basic science foundation. The results from the proposed research will establish a structural framework for the brain-body connection and thus, create new opportunities for rigorous research and novel approaches for treatment. This information, because of its all-encompassing nature, will be of interest to many, if not all of the NIH Institutes and Centers.

我们对大脑与身体连接的神经基础几乎一无所知。这个连接是 使运动、认知和情感处理对大脑功能产生重大影响的电路 内脏，如胃、心、脾。这些网络中的不适当信号被认为 导致一些流行的医学疾病的产生，并导致所谓的“功能性” 和心身疾病。本申请中提出的实验将填补我们的一项重大空白 知识。我们将确定影响并在某些情况下控制功能的皮质区域 胃肠道 (GI)、心血管和免疫系统。 大脑与身体的连接基于突触连接的神经元链。无常规 神经解剖学示踪剂能够揭示多突触回路。为了克服这个缺点，我们 开发了使用狂犬病病毒作为非人类灵长类动物的跨神经元示踪剂。我们建议使用这个 揭示造成自上而下影响的复杂网络的独特方法 中枢神经系统在胃、心脏和脾脏。 人们越来越认识到许多医学症状，尤其是那些无法识别的症状 病理学上，可能是由大脑与身体连接的紊乱引起的。对于以下情况尤其如此 通常是顽固性疾病，如肠易激综合症、压力和抑郁相关的心脏病、 和纤维肌痛。因此，从我们的研究中获得的信息有可能改变我们的方式 我们观察并治疗这些疾病。 从本质上讲，大脑与身体的联系是一种缺乏具体基础科学基础的构造。 拟议研究的结果将为大脑与身体的连接建立一个结构框架 从而为严谨的研究和新颖的治疗方法创造新的机会。这 由于其包罗万象的性质，许多（如果不是全部）NIH 研究所都会对这些信息感兴趣 和中心。