Training in the Neurobiology of Neurological Disease

神经系统疾病的神经生物学培训

• 批准号: 9923004
• 负责人: Peter Strick
• 金额: $ 43.36万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9923004
• 关键词: Neurobiology; Training; nervous system disorder

This proposal requests renewal of postdoctoral training in the Neurobiology of Neurological Disease. This is a 2 year program that currently funds six fellows each year. Due to the success of this program, as well as the large number of qualified candidates and faculty mentors, we seek an increase to cover eight fellows. Our program has five primary goals: 1) To foster understanding of the diseases and syndromes that are of high relevance to NINDS; 2) To ensure that trainees are appropriately mentored in their research and that they acquire the professional skills necessary for independent careers in neuroscience; 3) To afford opportunities for innovative research; 4) To attract underrepresented minorities to postdoctoral training in neuroscience; and 5) To support training of "special cases" – individuals whose needs differ from those of the typical training fellow. These special cases may include individuals with computational backgrounds who now seek biological training, as well as young scientists who take on projects that require extended time and effort for completion. Our program requires trainees to be active participants in a two-year course on the “Neurobiology of Disease.” Many sessions of the course are taught by an academic clinician and a basic scientist, and include patients to illustrate a relevant disease or syndrome that is the topic of the session. The course is spread over two years to cover the full spectrum of diseases and syndromes. This time period also makes it easier to schedule the participation of patients and active clinicians. At least two presentations per year are devoted to critical analysis of clinical research, as well as basic science papers. This allows trainees to discuss issues relevant to experimental design and data analysis. We also provide trainees with a two-step "Professional Development Series" that is tailored to the specific needs of early- and late-phase postdoctoral fellows in neuroscience. The professional development series includes topics ranging from grant writing to exploring job opportunities and setting up a first lab. Trainees can also take additional courses, as needed, to fill in gaps in their background. At the core of every postdoctoral experience is mentored research in an accomplished laboratory. To oversee this experience we have devised a mentoring program that includes regular review of both the trainee and the mentor. Each trainee has a primary research adviser as well as an individualized Research Advisory Committee. This arrangement has proven to be especially helpful to Early Stage Investigators who have trainees in their laboratories for the first time. Our 49 training faculty supervise 55 postdoctoral trainees. More than half of these trainees are eligible for individual NRSA and/or T32 support. We believe that the quality and breadth of our faculty, the state-of-the-art facilities, and the unique nature of our training program enable us to attract outstanding fellows and provide them with a special experience.

该提案要求更新神经疾病神经生物学的博士后培训。 这是一个为期 2 年的计划，由于该计划的成功，目前每年资助六名研究员。 由于合格的候选人和教师导师数量众多，我们寻求增加八名研究员。 我们的计划有五个主要目标： 1) 促进对高危疾病和综合征的了解 与 NINDS 的相关性； 2) 确保受训者在其研究中得到适当的指导并确保他们 获得神经科学独立职业所需的专业技能；3）提供机会； 4）吸引代表性不足的少数群体接受神经科学博士后培训； 5) 支持“特殊情况”的培训——需求与典型培训不同的个人 这些特殊情况可能包括具有计算背景但现在寻求生物学的个人。 培训，以及承担需要延长时间和精力才能完成的项目的年轻科学家。 我们的计划要求学员积极参加为期两年的“神经生物学”课程 该课程的许多课程均由学术临床医生和基础科学家教授，包括 患者来说明课程主题的相关疾病或综合症。 两年的时间涵盖了所有的疾病和综合症，这段时间也让治疗变得更容易。 安排患者和积极信徒的参与，每年至少有两次演讲。 对临床研究以及基础科学论文的批判性分析允许学员讨论问题。 我们还为学员提供了与实验设计和数据分析相关的两步“专业”课程。 发展系列”专为早期和晚期博士后研究员的具体需求而设计 专业发展系列包括从资助写作到探索工作等主题。 机会并建立第一个实验室，学员还可以根据需要参加额外的课程，以填补空缺。 他们的背景。 每个博士后经历的核心都是在完善的实验室中进行指导性研究。 为了监督这一经历，我们设计了一个指导计划，其中包括对受训者进行定期审查 每位学员都有一名主要研究顾问以及个性化的研究咨询。 事实证明，这种安排对早期研究人员特别有帮助。 受训人员第一次进入自己的实验室。 我们的49名培训教师指导了55名博士后培训生，其中超过一半的培训生符合资格。 对于个人 NRSA 和/或 T32 支持，我们相信我们教师的质量和广度， 最先进的设施和独特的培训计划使我们能够吸引优秀的研究员 并为他们提供特殊的体验。