Center for neuroscience research in non-human primates (CNRN)

非人类灵长类动物神经科学研究中心 (CNRN)

基本信息

批准号：
8452966
负责人：
Peter Strick
金额：
$ 59.44万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-30 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8452966
关键词：
Allegra Anesthesia procedures Animal Technicians Animals Aventyl Basic Science Behavioral Biological Models Biomedical Engineering Brain Brain imaging Brain region Caring Cercopithecidae Certified registered nurse anesthetist Clinical Complex Computers Core Facility Data Dura Mater Electrodes Electronics Ensure Equipment Faculty Fostering Future Goals Grant Histology Housing Human Resources Huntington Disease Image Immunization Injection of therapeutic agent Institution Instruction Investments Knowledge Magnetic Resonance Imaging Maintenance Mechanics Medical Methodology Mission Modeling Monkeys Movement National Institute of Neurological Disorders and Stroke Neurodegenerative Disorders Neurosciences Neurosciences Research Operative Surgical Procedures Parkinson Disease Parkinsonian Disorders Perioperative Nursing Personal Satisfaction Principal Investigator Procedures Process Qualifying Quarantine Recovery Research Research Infrastructure Research Personnel Research Project Grants Resources Scanning Scientist Services Sister Speed Spinal Cord Staging Stroke System Testing Tissues Tracer Training Translations Universities Veterinarians Work awake coping database structure design experience improved instrument interest meetings nervous system disorder neurophysiology nonhuman primate novel optical imaging programs psychologic psychosocial relating to nervous system repaired research study spinal cord and brain injury

项目摘要

DESCRIPTION (provided by applicant): The goal of this application is to establish a "Center for Neuroscience Research in Non-Human Primates" (CNRN) at the University of Pittsburgh. Each of the Center's six Cores - (1) Veterinary Services; (2) Surgery; (3) Histology; (4) Imaging; (5) Bioengineering, Computing, and Electronics; and (6) Administration - is designed to meet the specialized needs for neuroscience-related research in awake, behaving non-human primates (NHPs). The CNRN has 3 main goals: (1) To support the neuroscience research of current major users of non-human primates; (2) To make resources available to Early Stage Investigators who are setting up labs to work with NHPs; and (3) To enable investigators who work with other model systems to perform "proof of principle" studies in NHPs. The Center's resources will be available not only to investigators at the University of Pittsburgh, but also to those at our sister institution, Carnegie Mellon University. The CNRN does not overlap or duplicate other facilities within the University. Indeed, certain types of research will only be possible because of the existence of the Center. The Center has 9 "NINDS-qualifying" research projects directed by 6 separate Principal Investigators. Overall, the Center will serve the needs of faculty in multiple Basic Science (4) and Clinical Departments (11), including 17 heavy users, 6 Early Stage Investigators, and 11 investigators who have expressed an interest in testing their ideas in a NHP model. In summary, the CNRN will be a critical resource for at least 28 scientists with 50 grants (30 of which are NINDS grants) at 2 major institutions, the University of Pittsburgh and Carnegie Mellon University. The Center will serve multiple Centers of Excellence at the University of Pittsburgh including those focused on topics of primary interest to the mission of NINDS, such as Parkinson's and Huntington's Diseases, traumatic brain and spinal cord injury, stroke and the normal and abnormal control of movement.

描述（由申请人提供）：本申请的目标是在匹兹堡大学建立“非人类灵长类动物神经科学研究中心”（CNRN）。该中心的六个核心分别是：(1) 兽医服务； (2) 手术； (3)组织学； (4) 影像学； (5) 生物工程、计算机和电子； (6) 管理——旨在满足对清醒、有行为能力的非人类灵长类动物 (NHP) 进行神经科学相关研究的特殊需求。 CNRN 有 3 个主要目标：（1）支持非人类灵长类动物当前主要用户的神经科学研究； (2) 为正在建立实验室与 NHP 合作的早期研究人员提供资源； (3) 使使用其他模型系统的研究人员能够在 NHP 中进行“原理证明”研究。该中心的资源不仅可供匹兹堡大学的研究人员使用，也可供我们的姊妹机构卡内基梅隆大学的研究人员使用。 CNRN 不会与大学内的其他设施重叠或重复。事实上，某些类型的研究只有因为该中心的存在才成为可能。该中心拥有 9 个“NINDS 合格”研究项目，由 6 名独立首席研究员指导。总体而言，该中心将满足多个基础科学部门 (4) 和临床部门 (11) 教师的需求，包括 17 名重度用户、6 名早期研究人员和 11 名表示有兴趣在 NHP 模型中测试其想法的研究人员。总之，CNRN 将成为匹兹堡大学和卡内基梅隆大学这两个主要机构的至少 28 名科学家的重要资源，并获得 50 项资助（其中 30 项是 NINDS 资助）。该中心将为匹兹堡大学的多个卓越中心提供服务，包括那些关注 NINDS 使命主要感兴趣主题的中心，例如帕金森病和亨廷顿病、创伤性脑和脊髓损伤、中风以及正常和异常的运动控制。