Intergenerational Vestiges of Childhood Maltreatment: Physiological Mediating Mechanisms of Parenting

童年虐待的代际痕迹：养育的生理中介机制

• 批准号: 10705055
• 负责人: Hannah Grace Swerbenski
• 金额: $ 4.77万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10705055
• 关键词: Achievement; Address; Adrenal Glands; Affect; Affective; Age; Area; Award; Behavior; Behavioral; Biological; Caustics; Cessation of life; Child; Child Abuse and Neglect; Child Rearing; Complement; Cues; Data; Dedications; Development; Distress; Education; Emotional; Exposure to; Fostering; Future Generations; Generations; Goals; Heart Diseases; Homeostasis; Human; Hypothalamic structure; Impaired cognition; Informal Social Control; Intervention; Knowledge; Life; Link; Longevity; Low income; Mediating; Mediator; Mentors; Mentorship; Methods; Modeling; Mothers; Motivation; Obesity; Outcome; Parasympathetic Nervous System; Parent-Child Relations; Parents; Pathway interactions; Physiological; Physiology; Pituitary Gland; Postpartum Period; Pregnant Women; Prevention; Process; Psychopathology; Public Health; Recording of previous events; Recovery; Research; Research Personnel; Research Training; Risk; Risk Factors; Scientist; Social Environment; Specificity; System; Time; Training; Translational Research; Withdrawal; Woman; Work; biological adaptation to stress; biopsychosocial; career; caregiving; clinical practice; cognitive function; cost; early childhood; emotional functioning; fighting; flexibility; high risk; hypothalamic-pituitary-adrenal axis; infancy; informant; intergenerational; longitudinal, prospective study; maltreatment; maternal caregiving; next generation; novel; parental influence; perinatal period; physical conditioning; postnatal; prenatal; programs; psychological outcomes; resilience; response; skills; social engagement; stress reactivity; substance use; theories; training opportunity; transmission process

PROJECT SUMMARY/ABSTRACT Childhood maltreatment constitutes a grave public health crisis associated with devastating lifelong costs, including heightened risk for psychopathology1,2 and substance use,3 poorer socioemotional functioning,4,5 impaired cognitive functioning,6,7 lower educational attainment,8 and physical health problems9 such as heart disease,10 obesity,11 and even early death.12 Crucially, the deleterious costs of childhood maltreatment are not limited to those directly affected, but can also spillover into future generations via disrupted parenting and caregiving practices.13 Thus, identification of intervening mechanisms that may explain associations between maltreatment histories and parenting in the next generation can inform theory in this area of research and illuminate meaningful points of intervention in clinical practice. The long-term objective of the proposed project is to examine multisystem physiological stress reactivity indicators as mediators of associations between maternal maltreatment histories and parenting during the perinatal period. The novelty of this project is twofold. First, this project will examine both Hypothalamic-Pituitary-Adrenal reactivity (Aim 1) and Parasympathetic Nervous System reactivity (Aim 2) as intervening links between maltreatment and parenting during a key developmental period. This is the first study to examine more than one physiological mediator of this association concurrently, as well as the first study to examine parasympathetic reactivity specifically. Second, informed by a Domain-Specific Approach14 to parenting, this project provides much-needed specificity in differential associations between physiology and parenting outcomes across the protection and reciprocity domains. This work addresses limitations of prior research by leveraging an existing prospective, longitudinal, study (n=85) of diverse, low-income women. The applicant’s dedicated mentorship team of expert investigators will foster the applicant's development in this important research area. Finally, the award and completion of this project will substantially aid in providing strong research training to a promising young scientist in developmental psychopathology, intergenerational transmission processes, and human physiology through quality mentoring and training opportunities for advanced research skills and enhanced interdisciplinary knowledge in relevant content areas. Moreover, the proposed translational research is highly novel and will contribute to knowledge of biopsychosocial parenting processes in the perinatal period, particularly among high-risk mothers.

项目摘要/摘要 儿童虐待构成了与毁灭性终生成本相关的严重公共卫生危机， 包括心理病理学的风险增加1,2和药物使用，3个较差的社会情感功能，4,5 认知功能受损，6,7较低的教育程度，8和身体健康问题。 疾病，10个肥胖，11甚至早期死亡。12至关重要的是，儿童虐待的删除成本不是 仅限于直接影响的人，但也可以通过破坏的育儿和 13识别中间机制，这些机制可能解释了可能解释的关联 下一代中的虐待历史和育儿可以在这一研究领域的理论和 在临床实践中阐明有意义的干预点。提议的长期目标 项目将检查多系统的物理压力反应指标，作为关联的介体 在围产期期间的遗嘱虐待历史和育儿之间。这个新奇 项目是双重的。首先，该项目将检查下丘脑 - 垂体 - 肾上腺反应性（AIM 1）和 副交感神经系统反应性（AIM 2）作为虐待与育儿之间的中间联系 在关键的发展时期。这是第一个研究多个物理调解人的研究 该关联是同时研究副交感反应性的第一项研究。 其次，由特定于领域的方法14育儿的育儿，该项目提供了急需的特殊性 在保护和互惠之间的生理学和育儿成果之间的差异关联中 域。这项工作通过利用现有的前瞻性，纵向， 潜水员，低收入妇女的研究（n = 85）。申请人专业研究员的专门精力研究团队 将在这个重要的研究领域促进申请人的发展。最后，奖励和完成 项目将大大帮助提供强大的研究培训，以向年轻科学家提供发展 精神病理学，代际传播过程和人类生理学通过质量心理 以及高级研究技能的培训机会，并增强了相关方面的跨学科知识 内容区域。此外，拟议的翻译研究非常新颖，将有助于了解 生物心理社会育儿过程在围产期期间，尤其是在高危母亲中。