Direct Write Microfabrication Platform for Biomedical Research

用于生物医学研究的直写微加工平台

• 批准号: 7794375
• 负责人: Lance C Kam
• 金额: $ 17.98万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-15 至 2011-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794375
• 关键词: Area; Arts; Biomedical Research; Cell Culture Techniques; Cells; Communities; Complement; Complex; Diagnostic; Engineering; Environment; Equipment; Interest Group; Lasers; Masks; Microfabrication; Miniaturization; Pattern; Process; Research; Research Personnel; Resources; Scanning; Science; Surface; System; Systems Analysis; Techniques; Universities; Work; Writing; cost; design; interest; lithography; meetings; research study

DESCRIPTION (provided by applicant): Microscale systems have a strong and increasing presence in basic and applied biomedical research. The ability to manipulate and define an experimental system at the scale of micrometers has revealed much about how cells interact with their complex environment. Conversely, miniaturization of biomolecular analyses systems hold the promise of transportable and effective diagnostics. We are proposing to purchase a microfabrication platform to accelerate research into these fields on the Columbia University campus. This area of research has seen a tremendous increase in recent years on this campus, and currently our need for sophisticated microfabrication is not met through resources on campus or in the local area. Specifically, we have a need for fabrication techniques that provide patterning of micrometer scale features over areas sufficiently large to carry out contemporary cell culture experiments. The platform we are proposing is a state-of-the-art laser lithography platform, with a minimum feature size of 1 micrometer. In addition to providing much needed capacity, this platform offers several key capabilities. In this approach, a laser is scanned across a working surface, directly exposing designated regions of the substrate for later processing. By circumventing the need for a photolithographic mask, this approach shortens the design/analysis cycle for micropatterning, and dramatically reduces the cost of each iteration. In addition, control over the laser intensity makes possible a range of advance patterning techniques for making complex surfaces. This apparatus will complement the facilities currently in place on the Columbia University campus, providing an important resource for this community. The team of investigators in this proposed project represents a wide range of biomedical science and engineering interests. By making this capacity available to this diverse group of interests, the proposed equipment will have a wide impact on accelerating research.

描述（由申请人提供）：微观系统在基本和应用的生物医学研究中具有强大而越来越多的存在。在微米尺度上操纵和定义实验系统的能力已经揭示了细胞如何与它们的复杂环境相互作用。相反，生物分子分析系统的小型化具有可运输有效诊断的希望。 我们建议购买一个微加工平台，以加速哥伦比亚大学校园的这些领域的研究。近年来，该校园的这一研究领域的增长幅度很大，目前我们需要通过校园或当地的资源来满足复杂的微加工的需求。具体而言，我们需要制造技术，这些技术在足够大以进行现代细胞培养实验的区域内提供了千分尺特征的图案。 我们提出的平台是一个最新的激光光刻平台，最小特征大小为1微米。除了提供急需的容量外，该平台还提供了多种关键功能。在这种方法中，在工作表面扫描激光，直接暴露基材的指定区域以进行以后处理。通过规避对光刻面膜的需求，此方法缩短了微观图案的设计/分析周期，并大大降低了每次迭代的成本。此外，对激光强度的控制使得可以采取一系列用于制造复杂表面的提前模式技术。该设备将补充哥伦比亚大学校园目前现有的设施，为该社区提供重要资源。 该拟议项目中的调查人员团队代表了广泛的生物医学科学和工程兴趣。通过使这一多元化兴趣群的能力可用，拟议的设备将对加速研究产生广泛的影响。