Cancer Control and Population Sciences Research Program

癌症控制与人口科学研究计划

基本信息

批准号：
10625755
负责人：
Dejana K Braithwaite
金额：
$ 7.12万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10625755
关键词：
Abbreviations Achievement Address Advocate Age Aging Agriculture Area Arts Behavioral Biological Sciences Biomedical Research Biometry Black race Breast Breast Cancer Detection Cancer Biology Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Cancer Etiology Cancer Prevention Intervention Cancer Survivor Catchment Area Clinical Sciences Collaborations Colorectal Communication Communities Community Outreach Confocal Microscopy Dentistry Development Diagnostic Diet Discipline of Nursing Disparity Dissemination and Implementation Early Diagnosis Elderly Electronic Health Record Engineering Enrollment Equilibrium Etiology Extramural Activities Florida Flow Cytometry Funding Future Goals Grant Guidelines Health Health Occupations Hepatitis C Therapy Hispanic Human Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Papilloma Virus-Related Malignant Neoplasm Immune response Incidence Informatics Institution Interdisciplinary Study Intervention Intervention Studies Intervention Trial Journalism Last Name Late Effects Lung Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of prostate Medicine Mentors Molecular Not Hispanic or Latino Obesity Observational Study Outcome Participant Patient Outcomes Assessments Peer Review Performance Pharmacy facility Physical activity Policies Population Population Heterogeneity Population Sciences Postdoctoral Fellow Pragmatic clinical trial Prevention program Prevention strategy Primary Cancer Prevention Public Health Publications Publishing Radiation Radiation Dose Unit Research Research Activity Research Design Research Personnel Resource Sharing Risk Factors Rural Rural Population Sales Science Screening for cancer Secondary Cancer Prevention Smoking Strategic Planning Survivors Symptoms Testing Therapeutic Tobacco Tobacco Control Research Tobacco use Training Training and Education Translating Translational Research Underrepresented Minority Underserved Population Universities Woman anticancer research cancer health disparity cancer imaging cancer prevention cancer risk cancer therapy clinical practice clinical trial enrollment college colorectal cancer screening community engaged research community engagement community partnership digital digital health effectiveness trial efficacy trial energy balance ethnic minority graduate student high risk human old age (65+)imaging biomarker implementation science innovation medically underserved population member modifiable risk molecular marker mortality next generation sequencing novel older men older women patient engagement personalized intervention pragmatic trial prevent programs proton therapy racial minority recruit rural counties scale up screening social social determinants survivorship tool translational pipeline treatment response trial design tumorigenesis vaccine acceptance

项目摘要

CANCER CONTROL AND POPULATION SCIENCES (CCPS): ABSTRACT The Cancer Control and Population Sciences (CCPS) program at the University of Florida Health Cancer Center (UFHCC) is led by Braithwaite and Krieger. The goal of the CCPS program is to reduce the cancer burden in rural North Central Florida and beyond. The CCPS program’s specific aims are to: 1) Elucidate molecular, behavioral, social, environmental, and other risk factors in cancer incidence and mortality; 2) Develop and evaluate primary and secondary cancer prevention interventions; and 3) Address the unique needs of cancer survivors. Research activities are unified by 5 CCPS priorities that address the cancer burden of the catchment area (CA): a) social determinants and cancer disparities; b) smoking and other tobacco use; c) molecular and imaging markers; d) obesity, energy balance, and cancer; and e) the intersection of cancer and aging. To capture the research strengths at the University of Florida (UF), CCPS assembled 48 members drawing a wide range of expertise from 20 departments and 10 colleges. The organization of CCPS has a culture of multidisciplinary collaboration with other UFHCC programs, shared resources, Community Outreach and Engagement (COE), and Cancer Research Training and Education, enabling research excellence across the translational spectrum. Since 2016, key achievements of the program include evaluating the performance of breast cancer screening in older women, developing novel cancer communication strategies to increase colorectal cancer screening and HPV vaccine uptake, performing studies that informed raising the age of tobacco sale in Florida, developing radiation dosing tools to prevent harmful effects of diagnostic and therapeutic radiation, assessing Hepatitis C treatments that reduce liver cancer risk, and developing digital patient-reported outcome tools. Since 2016, program members published 1,114 cancer-relevant publications, ~7% with impact factors >10. CCPS members enrolled 6,528 participants on interventional trials, including a pragmatic clinical trial examining patient-reported outcomes following proton therapy among older men with prostate cancer, and 13,064 participants on non- interventional studies. Through our efforts, robust collaboration is evident with 40% intra-programmatic, 29% inter-programmatic, and 73% multi-institutional publications. CCPS members hold >$11.5M in external peer- reviewed funding (up 48% since 2019), with >$3.7M from the NCI. CCPS mentors trained 186 graduate students and 30 postdocs, of whom 66% are women and 19% underrepresented minorities (URM). CCPS future directions are aligned with the UFHCC strategic plan, Momentum 2027, seeking further recruitments, scientific progress, and impact building on the research expertise of the UFHCC and community partnerships. Driven by the CA needs, future development includes expansion of tobacco control research, cancer communication, and screening. CCPS will address the intersectional problems of aging and cancer, obesity and cancer, and the impact of social determinants on cancer outcomes. In partnership with COE, CCPS will disseminate research findings and best practices across the CA and beyond.

癌症控制和人口科学 (CCPS)：摘要佛罗里达大学健康癌症中心的癌症控制和人口科学 (CCPS) 项目 (UFHCC) 由 Braithwaite 和 Krieger 领导，CCPS 计划的目标是减少癌症负担。 CCPS 计划的具体目标是： 1) 阐明分子、癌症发病率和死亡率的行为、社会、环境和其他风险因素 2) 发展和评估一级和二级癌症预防干预措施；3) 满足癌症的独特需求研究活动由 5 个 CCPS 优先事项统一起来，解决该地区的癌症负担。领域 (CA)：a) 社会决定因素和癌症差异；b) 吸烟和其他烟草使用；c) 分子和成像标记；d) 肥胖、能量平衡和癌症；以及 e) 癌症和衰老的交叉点。充分发挥佛罗里达大学 (UF) 的研究优势，CCPS 聚集了 48 名成员，涵盖广泛的领域 CCPS 的组织拥有来自 20 个系和 10 个学院的专业知识。与其他 UFHCC 项目合作、共享资源、社区外展和参与 (COE)、癌症研究培训和教育，实现跨转化领域的卓越研究。自 2016 年以来，该计划的主要成就包括评估乳腺癌筛查的表现老年妇女，制定新的癌症沟通策略以增加结直肠癌筛查和 HPV 疫苗的采用，进行的研究为提高佛罗里达州的烟草销售年龄提供了信息，正在开发辐射剂量工具可防止诊断和治疗辐射的有害影响，评估丙型肝炎降低肝癌风险的治疗方法，并开发数字化患者报告结果工具自 2016 年以来，计划成员发表了 1,114 篇癌症相关出版物，其中约 7% 的 CCPS 成员的影响因子 >10。招募了 6,528 名参与者参加介入试验，包括一项检查患者报告的实用临床试验患有前列腺癌的老年男性和 13,064 名接受非治疗的参与者接受质子治疗后的结果通过我们的努力，强有力的合作是显而易见的，其中 40% 是项目内的，29% 是项目内的。跨项目和 73% 的跨机构出版物拥有超过 1150 万美元的外部同行出版物。审查的资金（自 2019 年以来增加了 48%），来自 CCPS 导师的超过 370 万美元培训了 186 名研究生。和 30 名博士后，其中 66% 是女性，19% 是代表性不足的少数族裔 (URM)。与 UFHCC 战略计划 Momentum 2027 保持一致，寻求进一步招募、科学进步、并在 UFHCC 和社区伙伴关系的研究专业知识的基础上发挥影响力，由 CA 推动。需求，未来的发展包括扩大烟草控制研究、癌症传播和 CCPS 筛查将解决衰老与癌症、肥胖与癌症以及癌症的交叉问题。 CCPS 将与 COE 合作传播研究成果。 CA 及其他地区的调查结果和最佳实践。