University of Florida Health Cancer Center Support Grant

佛罗里达大学健康癌症中心支持补助金

• 批准号: 10625750
• 负责人: Jonathan D. Licht
• 金额: $ 213.5万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625750
• 关键词: Abbreviations; Achievement; Address; Aging; Agriculture; American Cancer Society; Area; Arts; Basic Cancer Research; Biology; Biomedical Research; Biometry; Black race; Breast; Budgets; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Etiology; Cancer Research Project; Cancer Vaccines; Catchment Area; Cells; Classification; Clinic; Clinical; Clinical Cancer Center; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials Network; Collaborations; Colorectal; Communication; Communities; Community Outreach; Complex; Confocal Microscopy; County; Data Set; Dentistry; Development; Developmental Therapeutics Program; Diagnosis; Discipline of Nursing; Disease; Diverse Workforce; Educational Activities; Engineering; Faculty; Florida; Flow Cytometry; Fostering; Funding; Genetic Research; Goals; Health; Health Occupations; Health Sciences; Hispanic; Human; Human Papilloma Virus Vaccination; Immune response; Immunotherapy; Institution; Intervention; Intervention Trial; Journalism; Laboratories; Last Name; Lead; Lung; Malignant Neoplasms; Medically Underserved Area; Medicine; Mentorship; Mission; Molecular Carcinogenesis; NCI Center for Cancer Research; NCI-Designated Cancer Center; New England; Oncoproteins; Outcome; Patients; Peer Review; Performance; Persons; Pharmacy facility; Play; Population; Population Sciences; Preclinical Testing; Prevention; Prevention strategy; Prevention trial; Public Health; Publications; RNA; Regional Cancer; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rural; Science; Scientific Advances and Accomplishments; Scientist; Screening for cancer; Shapes; Site; Strategic Planning; Talents; Teacher Professional Development; Technology; Testing; Text; Therapeutic; Tobacco use; Training; Training Programs; Translating; Translational Research; Translations; Underrepresented Minority; Universities; Woman; Workforce Development; anticancer research; cancer health disparity; cancer prevention; cancer therapy; career; career development; clinically relevant; cohort; college; community engagement; diversity and inclusion; equity, diversity, and inclusion; health literacy; high school; improved; innovation; investigator-initiated trial; leadership development; leukemia; marine organism; member; microbiome; next generation; next generation sequencing; novel; personalized medicine; population based; prevent; programs; recruit; rural counties; screening; small molecule; smoking cessation; survivorship; targeted treatment; treatment response; tumorigenesis

OVERALL: ABSTRACT In recognition of achievements in fostering transdisciplinary research, inclusive workforce development, community engagement, and ability to enhance its impact on the catchment area (CA), the University of Florida Health Cancer Center (UFHCC) seeks NCI-Designation. UFHCC is a matrix center that supports cancer research and career enhancement across all 6 UF health sciences colleges (Dentistry, Medicine, Nursing, Pharmacy, Public Health & Health Professions, and Veterinary Med) and 5 other UF colleges (Agriculture, Engineering, Health & Human Performance, Journalism & Communications, and Liberal Arts & Sciences). Collaborative research is conducted by 147 members across 3 UFHCC scientific programs: Mechanisms of Oncogenesis, Cancer Therapeutics and Host Response, and Cancer Control and Population Sciences. The UFHCC provides access to state-of-the-art technologies and research expertise for its members through 3 shared resources: Biostatistics and Quantitative Sciences, Flow Cytometry and Confocal Microscopy, and Next Generation Sequencing. The UFHCC CA includes 23 contiguous counties in North Central Florida spanning ~17,500 mi2, about the size of Southern New England. Most of the counties (16) are rural and every county is classified as a Medically Underserved Area. The CA population is 2.2M and includes people who are Black (16%), Hispanic (10%), and has the highest fraction (23%) of residents ≥65 years in Florida. Through community outreach, UFHCC supports efforts to increase health literacy, prevention, screening, and research engagement. The UFHCC Clinical Research Office coordinates all cancer-relevant clinical research at UF, which includes a state-wide clinical trial network. IITs are facilitated through disease site groups with an IIT Think Tank that fosters clinician collaboration with basic and population scientists. UFHCC innovations translated to the clinic include targeted therapies, novel immunotherapies, therapeutic modulation of the microbiome, and new strategies to communicate with patients. UFHCC Developmental Funds seed early-stage research, support recruitment of new faculty, and build transdisciplinary teams. UFHCC offers inclusive research career enhancement programs across the learner spectrum. Since 2016, the UFHCC recruited 58 new members (45 external, 39 early-stage) (45% women, 17% URM). Peer-reviewed funding increased from $21M in 2016 to $32.6M/yr in 2021 (up 55%); NCI $9.6M to $13.2M (up 37%). Accruals to all interventional trials rose from 515 in 2016 to 1,748 in 2021 (up 3.4-fold). Institutional support of a $32M/year budget over the next 5 years and 44,000ft2 of new research space will allow UFHCC to expand. The new UFHCC strategic plan, Momentum 2027, has 4 pillars: 1) conduct transdisciplinary research (RNA biology, microbiome); 2) translate UFHCC discoveries to trials (immunotherapy, small molecules, cancer communication); 3) address cancer burden (cancer and aging, cancer health disparities); and, 4) train a prepared and diverse cancer research workforce, including leadership development. UFHCC is poised to make a major impact on the cancer burden of the catchment area, Florida, and beyond.

总体：摘要 认识到培养跨学科研究的成就，包容性劳动力发展， 社区参与以及增强其对集水区（CA）的影响的能力，佛罗里达大学 健康癌症中心（UFHCC）寻求NCI设计。 UFHCC是支持癌症的基质中心 所有6所UF健康科学学院的研究和职业增强（牙科，医学，护理， 药房，公共卫生与卫生专业人员以及兽医医学）和其他5所UF学院（农业， 工程，健康与人类绩效，新闻与传播以及文科与科学）。 协作研究由3个UFHCC科学计划的147名成员进行： 肿瘤发生，癌症治疗和宿主反应以及癌症控制和人群科学。这 UFHCC通过3提供了对其成员的最先进技术和研究专业知识的访问权限 共享资源：生物统计学和定量科学，流式细胞术和共聚焦显微镜，然后 生成测序。 UFHCC CA包括佛罗里达州中部的23个连续县 〜17,500 mi2，大约是新英格兰南部的大小。大多数县（16）都很粗糙，每个县都是 归类为医疗服务不足的地区。 CA人口为220万，包括黑人的人 （16％），西班牙裔（10％），在佛罗里达州≥65岁的居民的分数最高（23％）。通过社区 UFHCC推广，支持提高健康素养，预防，筛查和研究参与的努力。 UFHCC临床研究办公室协调UF的所有与癌症相关的临床研究，其中包括 全州临床试验网络。 IIT是通过疾病站点组制备的，该疾病部门具有促进的IIT智囊团 与基本和人群科学家的临床合作。 UFHCC创新转化为诊所包括 有针对性的疗法，新型免疫疗法，微生物组的治疗调节以及新的策略 与患者沟通。 UFHCC开发基金会种子早期研究，支持招募 新教师，并建立跨学科团队。 UFHCC提供包容性研究职业增强计划 跨学习者频谱。自2016年以来，UFHCC招募了58名新成员（45位外部，39个早期阶段） （45％女性，17％URM）。同行评审的资金从2016年的2100万美元增加到2021年/年的3260万美元（增长了55％）； NCI $ 960万美元至1320万美元（增长37％）。所有介入试验的应计值从2016年的515次上升到2021年的1,748（UP 3.4倍）。在未来5年内的3200万美元预算和44,000FT2的机构支持新研究领域 将允许UFHCC扩展。新的UFHCC战略计划，动量2027，有4个支柱：1）行为 跨学科研究（RNA生物学，微生物组）； 2）将UFHCC发现转化为试验（免疫疗法， 小分子，癌症传播）； 3）解决癌症伯恩（癌症与衰老，癌症健康 差异）； 4）培训一名准备好的和潜水的癌症研究人员，包括领导力发展。 UFHCC被中毒，对佛罗里达州集水区及其他地区的癌症伯恩（Cancer Burnen）产生重大影响。