2019 Cancer Genetics and Epigenetics GRC/GRS

2019年癌症遗传学和表观遗传学GRC/GRS

• 批准号: 9754282
• 负责人: Jonathan D. Licht
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754282
• 关键词: Biological Assay; CRISPR screen; Cancer Control; Chromatin; Chromatin Structure; Collaborations; Complement; Computer Analysis; Data; Epigenetic Process; Gene Expression; Gene Expression Profile; Gene Expression Regulation; Genetic Heterogeneity; Genome; Goals; Inter-tumoral heterogeneity; Knowledge; Lead; Malignant Neoplasms; Modernization; Molecular; Mutation; Pathway interactions; Play; Predisposition; RNA; Research; Research Personnel; Role; Scientist; Surveys; Systems Analysis; Tail; Tumor Biology; Untranslated RNA; Work; actionable mutation; cancer diagnosis; cancer genetics; cancer genome; cancer heterogeneity; cancer therapy; epigenome; experimental study; genome-wide; inhibitor/antagonist; meetings; posters; single cell technology; symposium; targeted treatment; tumor

Summary The 2019 Conference on Cancer Genetics and Epigenetics will focus on newly emerging aspects of the field including the genetic heterogeneity of cancer, the “long tail” of less frequent cancer mutations and the importance of intertumoral heterogeneity as assayed by single cell technologies. The importance of the non-coding genome in cancer will be highlighted as well as the rapidly evolving field of RNA epigenetics. Sessions on the lessons learned from genome wide surveys of cancer susceptibility as assayed by CRISPR screens and descriptions of cancer epigenomes will be complemented by talks on basic mechanism of gene regulation relevant to cancer and how genetically and epigenetically targeted therapies can be applied to specific tumor types. It has become increasingly apparent that the organization of the genome across temporal and spatial domains plays a large role in the control of cancer gene expression patterns and tumor biology and a session on the “4-D Nucleome” and cancer is planned. The large amounts of data generated by modern cancer genetic and epigenetic experiments require new modes of computational and systems analysis which will be discussed in sessions. This meeting should appeal to a wide range of cancer researchers and molecular biologists seeking to apply their work to cancer. In addition to an outstanding set of invited speakers there will be several interactive poster sessions, one-minute "poster preview" talks and several talks selected for platform presentation from the submitted abstracts.

概括 2019年癌症遗传学和表观遗传学会议将重点放在新兴的方面 该领域包括癌症的遗传异质性，癌症频繁的“长尾巴” 突变和单细胞分配的肿瘤间异质性的重要性 技术。非编码基因组在癌症中的重要性将得到强调，以及 RNA表观遗传学的快速发展的领域。从基因组范围内学到的课程的会议 由CRISPR筛选分配的癌症易感性的调查和癌症的描述 关于基因调节的基本机制的谈判将完成表观人体工程学 癌症以及遗传和表观靶向疗法如何应用于特定肿瘤 类型。越来越明显的是，基因组的组织跨临时 空间结构域在控制癌基因表达模式和肿瘤中起着重要作用 计划生物学和有关“ 4-D核心”和癌症的会议。大量数据 由现代癌症遗传和表观遗传实验产生的需要新的模式 将在会议中讨论的计算和系统分析。这次会议应该 呼吁广泛的癌症研究人员和分子生物学家寻求应用其工作 癌症。除了一组出色的邀请演讲者外，还将有几个互动性 海报会议，一分钟的“海报预览”演讲以及为平台选择的几次演讲 提交摘要的演讲。