Spatio-Temporal Organization of Chromatin and Information Transfer in Cancer

癌症中染色质的时空组织和信息传递

• 批准号: 8866966
• 负责人: Jonathan D. Licht
• 金额: $ 198.95万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-19 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8866966
• 关键词: Address; Advocate; Area; Basic Science; Biological Models; Biology; Cancer Biology; Cancer Control; Cancer Model; Cell Nucleus; Cellular biology; Chemicals; Chemistry; Chicago; Chromatin; Chromatin Structure; Chromosomes; Clinical; Collaborations; Communication; Communities; Comprehensive Cancer Center; Computer Simulation; Core Facility; Couples; DNA Packaging; Data; Diagnostic; Education and Outreach; Educational Activities; Educational workshop; Engineering; Ensure; Environment; Epigenetic Process; Faculty; Fostering; Funding; Funding Mechanisms; Gene Expression; Genes; Genetic; Genetically Engineered Mouse; Goals; Hematologic Neoplasms; Human; Imaging technology; Institutes; Ions; Knowledge; Leadership; Length; Life; Malignant Neoplasms; Measures; Mechanics; Methods; Modeling; Molecular; Mutation; Nuclear; Nuclear Structure; Outcome; Patients; Physics; Physiological; Plant Roots; Process; Recording of previous events; Regulatory Pathway; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Resource Allocation; Resource Sharing; Resources; Role; Science; Scientist; Techniques; Technology; Testing; Therapeutic; Therapeutic Intervention; Training; Translations; Work; Xenograft Model; anticancer research; base; cancer cell; cell fixing; cohesin; condensin; data integration; data modeling; design; frontier; high reward; high risk; imaging modality; in vitro Model; in vivo; innovation; insight; instrumentation; interest; meetings; member; neoplastic cell; next generation; novel; oncology; outreach; outreach program; physical science; programs; public health relevance; theories; three dimensional structure; tool; tumor; web site

 DESCRIPTION (provided by applicant): This application is organized around the framework of "Spatio-Temporal Organization of Chromatin and Information Transfer in Cancer". The organizing framework of the CR-PSOC integrates the strengths of chemistry, genetics, and physics to address chromatin dynamics in cancer. Through the use of shared model systems Center investigators will be able to integrate data from across projects to develop a new conceptual understanding of the mechanisms underlying physical rearrangement of chromatin in cancer and how that controls gene expression. The Center is composed of three interrelated project areas, each focused on different aspects of chromatin structure and function. Each project integrates emerging physical science approaches and molecular and cancer cell biology tools, as well as theory and modeling methods from the physical sciences, to achieve a quantitative and predictive understanding of the of deregulation of chromatin mechanics, epigenetic regulatory pathways, gene expression, and the nuclear environment in cancer. The Center's projects maintain a clear cancer focus rooted in understanding the molecular mechanism behind genetic alterations in chromatin regulators in cancer, particularly hematological malignancy. The scientific activities of the CR-PSOC will be supported by two shared resource cores: the Nanocytometry Core and the PDX Human Tumor Model Core. These cores will encompass unique resources that will not only benefit CR-PSOC investigators but will substantially augment the tools and approaches of investigators across the PSON. The proposed Chicago Region-Physical Science Oncology Center (CR-PSOC) brings together a unique constellation of physical science, chemical biology, and genetics expertise and couples this expertise with cutting edge analytical instrumentation, specialized sequencing technology, super high resolution imaging modalities, and novel cancer model systems. This combination of expertise and resources will enable Center investigators and members of the PSO Network to examine the structural and functional aspects of chromatin and nuclear dynamics in cancer at unprecedented depth and breadth. The CR-PSOC will provide a range of educational activities and programs designed to stimulate the interest and enhance the capabilities of the next generation of researchers working at the frontiers of physical science and oncology. Through integration of a patient advocate into Center administration with a key role in advising and supporting the translation of CR-PSOC discoveries the Center will maintain a steady focus on the importance of targeting clinical outcomes through advances in basic research.

 描述（由应用程序提供）：此应用程序是围绕“染色质时空组织和癌症信息转移”的框架进行组织的。 CR-PSOC的组织框架整合了化学，遗传学和物理学的优势，以解决癌症中的染色质动力学。通过使用共享模型系统中心研究人员将能够整合来自跨项目的数据，以对癌症中染色质的物理重排的机制进行新的概念理解，以及如何控制基因表达。该中心由三个相互关联的项目区域组成，每个项目都集中在染色质结构和功能的不同方面。每个项目都整合了新兴的物理科学方法以及分子和癌细胞生物学工具，以及物理科学的理论和建模方法，以实现对染色质力学，表观遗传调节途径，基因表达和核环境的定量和预测性理解。该中心的项目保持着明确的癌症焦点，该癌症源于了解癌症染色质调节剂（尤其是血液学恶性肿瘤）遗传改变背后的分子机制。 CR-PSOC的科学活动将由两个共享资源核心支持：纳米细胞仪和PDX人肿瘤模型核心。这些核心将涵盖独特的资源，不仅将使CR-PSOC调查人员受益，而且将大大增加PSON调查人员的工具和方法。拟议的芝加哥地区 - 物理肿瘤学中心（CR-PSOC）汇集了物理科学，化学生物学和遗传学专业知识的独特星座，并将这种专业知识与最先进的分析仪器，专业测序技术，超级高分辨率成像模式以及新颖的癌症模型系统结合在一起。这种专业知识和资源的结合将使中心的研究人员和PSO网络的成员能够检查前所未有的深度和广度下染色质和核动力学的结构和功能方面。 CR-PSOC将提供一系列旨在刺激兴趣并增强在物理科学和肿瘤学领域工作的研究人员的能力的教育活动和计划。通过将患者倡导者纳入中心管理，在咨询中发挥关键作用，并支持CR-PSOC发现的翻译，该中心将稳定地关注通过基础研究进步来靶向临床结果的重要性。