Center for the Study of Complex Malaria in India

印度复杂疟疾研究中心

• 批准号: 10117154
• 负责人: JANE M CARLTON
• 金额: $ 27.83万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10117154
• 关键词: Address; Anti-malarial drug resistance; Biological Markers; Biology; Blood Volume; Blood specimen; Clinic; Cohort Studies; Complex; Country; Detection; Development; Genes; Genome; Genomics; Haplotypes; Hot Spot; India; Individual; Infection; Knowledge; Malaria; Maps; Measures; Methods; Parasites; Patients; Plasmodium vivax; Population; Relapse; Research; Site; Technology; Time; base; genetic signature; genome sequencing; genomic platform; improved; nanopore; primary outcome; recurrent infection; relapse patients; screening; serological marker; tool; whole genome

PROJECT 2 SUMMARY In this project, we address key gaps in our knowledge of P. vivax hypnozoite biology through screening relapse patients for serological markers associated with the carriage of hypnozoites. We also plan to develop the Oxford Nanopore Technologies MinION genomics platform for use at our field sites in India. Finally, we will continue our development of a P. vivax haplotype map to identify India-specific selective sweeps and hot- spots, and sequence the genomes of P. vivax parasites from relapse patients. Our focus on P. vivax biology in this project is concordant with the recent announcement of an Indian National Framework for Malaria Elimination, which outlines a “Special strategy for P. vivax elimination” since “more than 80% of the global P. vivax burden is contributed by 3 countries including India”.

项目2摘要 在这个项目中，我们通过筛选继电器来解决对Vivax Hypnozoite生物学知识的关键差距 与催眠者载体相关的血清学标记患者。我们还计划开发 牛津纳米孔技术奴才基因组学平台可在我们的印度现场使用。最后，我们会的 继续我们开发Vivax单倍型图，以识别印度特定的选择性糖果和热 - 斑点和序列是退休患者的Vivax寄生虫的基因组。我们专注于Vivax生物学 该项目与最近宣布的印度国家疟疾框架一致 淘汰，概述了“全球P.的80％以上”，概述了“消除疟原虫的特殊策略”。 Vivax Burnen由包括印度在内的3个国家贡献。”