Center for the Study of Complex Malaria in India

印度复杂疟疾研究中心

• 批准号: 10117154
• 负责人: JANE M CARLTON
• 金额: $ 27.83万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10117154
• 关键词: Address; Anti-malarial drug resistance; Biological Markers; Biology; Blood Volume; Blood specimen; Clinic; Cohort Studies; Complex; Country; Detection; Development; Genes; Genome; Genomics; Haplotypes; Hot Spot; India; Individual; Infection; Knowledge; Malaria; Maps; Measures; Methods; Parasites; Patients; Plasmodium vivax; Population; Relapse; Research; Site; Technology; Time; base; genetic signature; genome sequencing; genomic platform; improved; nanopore; primary outcome; recurrent infection; relapse patients; screening; serological marker; tool; whole genome

PROJECT 2 SUMMARY In this project, we address key gaps in our knowledge of P. vivax hypnozoite biology through screening relapse patients for serological markers associated with the carriage of hypnozoites. We also plan to develop the Oxford Nanopore Technologies MinION genomics platform for use at our field sites in India. Finally, we will continue our development of a P. vivax haplotype map to identify India-specific selective sweeps and hot- spots, and sequence the genomes of P. vivax parasites from relapse patients. Our focus on P. vivax biology in this project is concordant with the recent announcement of an Indian National Framework for Malaria Elimination, which outlines a “Special strategy for P. vivax elimination” since “more than 80% of the global P. vivax burden is contributed by 3 countries including India”.

项目 2 总结 在这个项目中，我们通过筛查复发来解决间日疟原虫休眠子生物学知识中的关键空白 我们还计划开发与休眠子携带相关的血清学标记物。 Oxford Nanopore Technologies MinION 基因组学平台将在我们位于印度的现场使用。 继续开发间日疟原虫单倍型图谱，以确定印度特有的选择性扫描和热点 对来自复发患者的间日疟原虫进行斑点和基因组测序我们的重点是间日疟原虫生物学。 该项目与最近宣布的印度国家疟疾框架一致 消除，其中概述了“消灭间日疟原虫的特别策略”，因为“全球超过 80% 的间日疟原虫为消除间日疟原虫。” 间日疟原虫负担由印度等3个国家承担”。