Center for the Study of Complex Malaria in India

印度复杂疟疾研究中心

基本信息

批准号：
10379247
负责人：
JANE M CARLTON
金额：
$ 179.11万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10379247
关键词：
Adult Age Antibodies Antiparasitic Agents Area Binding Biological Biological Markers Biology Biostatistics Core Brain Brain Edema Brain Pathology CD4 Positive T Lymphocytes Censuses Cerebral Malaria Cerebrum Childhood Clinic Clinical Cohort Studies Complex Country Cross-Sectional Studies Data Democracy Detection Development Diagnosis Disease Effectiveness Epidemiology Genetic Genomics Genotype Geography Goals Human Hypoxia Imaging Techniques Immune Immune response Immunity Incidence India Individual Infection Integration Host Factors Intervention Knowledge Link Location Magnetic Resonance Magnetic Resonance Imaging Malaria Malawi Methods MicroRNAs Molecular Morbidity - disease rate Natural Selections Organ Outcome Parasites Pathogenesis Pathology Patients Pattern Recognition Perfusion Persons Phenotype Plasmodium Plasmodium vivax Population Process Public Health Relapse Research Research Institute Research Project Grants Retina Retinal Diseases Role Sampling Serology Severities Signal Transduction Site Spectrum Analysis Surveys Symptoms Time Tissues Variant activated protein C receptor age related base biomarker identification cohort comparative data management density differential expression disease transmission effectiveness evaluation evidence base genetic signature high risk improved insight international center malaria infection male mortality outcome prediction primary outcome programs regional difference serological marker tool vector mosquito

项目摘要

OVERALL SUMMARY In India, the world's largest democracy and second most populous country, malaria remains an enormous public health problem. Malaria in India is 'complex'; two predominant species of parasite may be present serially or concurrently in one person. Each species also has multiple strains (genotypes) that can serially or concurrently infect. Indian malaria complexity, its variation by location, and its consequences for malaria immunity and severity, are the research focus of the CSCMi. The aims of the Center are to develop the knowledge, tools, and evidence-based strategies needed to support Indian intervention and control programs, and to build research capacity in India. CSCMi research comprises three projects: Project 1: Epidemiology of malaria and infection dynamics, Project 2: P. vivax diagnosis, genomics and biology, and Project 3: Pathogenesis of cerebral malaria. Project 1 will undertake census, cross-sectional surveys, survey-cohorts, and clinic-based cohort studies for malaria baseline epidemiology and identification of asymptomatic n=and relapse individuals at our three ecologically and epidemiologically diverse field sites in Sundergarh District, Odisha, West Garo Hills in Meghalaya, and Jaintia Hills in Meghalaya. It will use biological samples collected during these studies to assess how infection complexity impacts seroepidemiology and CD4+ immune signatures in asymptomatic versus clinical malaria. Project 2 will investigate biomarkers of P. vivax hypnozoite infection, and deploy real-time genomics methods of diagnosis and for population genomics. Project 3 will use magnetic resonance imaging techniques to study cerebral malaria pathogenesis in an unprecedented and comprehensive comparative analysis between patients in India and Malawi, and investigate molecular pathogenetic mechanisms of disease. The CSCMi projects will be supported by an Administrative Core and Data Management and Biostatistics Core, and advised by a team of consultants and a Scientific Advisory Group.

总体总结在印度这个世界上最大的民主国家和人口第二多的国家，疟疾仍然是一个巨大的疾病公共卫生问题。印度的疟疾很“复杂”；可能存在两种主要的寄生虫种类连续或同时发生在一个人身上。每个物种还具有多个菌株（基因型），可以连续或同时感染。印度疟疾的复杂性、地区差异及其对疟疾的影响免疫和严重程度是CSCMi的研究重点。该中心的目标是发展支持印度干预和控制计划所需的知识、工具和基于证据的战略，并建设印度的研究能力。 CSCMi 研究包括三个项目：项目 1：流行病学疟疾和感染动态，项目 2：间日疟原虫诊断、基因组学和生物学，项目 3：脑型疟疾的发病机制。项目 1 将进行人口普查、横断面调查、队列调查、和基于临床的疟疾基线流行病学队列研究和无症状 n=and 的识别我们位于桑德加尔区的三个生态和流行病学不同的现场地点的复发个体，奥里萨邦、梅加拉亚邦的西加罗山和梅加拉亚邦的贾因蒂亚山。它将使用收集的生物样本在这些研究中评估感染复杂性如何影响血清流行病学和 CD4+ 免疫无症状疟疾与临床疟疾的特征。项目2将研究间日疟原虫休眠子的生物标志物感染，并部署实时基因组学诊断方法和群体基因组学。项目3将使用磁共振成像技术以前所未有的方式研究脑型疟疾发病机制对印度和马拉维患者进行全面比较分析，并研究分子水平疾病的发病机制。 CSCMi 项目将得到行政核心和数据管理和生物统计核心，并由顾问团队和科学顾问提供建议团体。