Center for the Study of Complex Malaria in India

印度复杂疟疾研究中心

• 批准号: 8508823
• 负责人: JANE M CARLTON
• 金额: $ 169.66万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8508823
• 关键词: Accounting; Anti-malarial drug resistance; Blood specimen; Cellular biology; Clinical Research; Complex; Country; Democracy; Diagnosis; Diagnostic tests; Disease; Drug resistance; Ecology; Epidemic; Epidemiology; Evolution; Faculty; Far East; Genetic; Genomics; Genotype; Goals; Government; Immunity; Immunology; India; Individual; Infection; Insecticides; Institutes; Interdisciplinary Study; Intervention; Knowledge; Laboratories; Location; Malaria; Medical Research; Methods; Molecular; New York; Parasites; Pathology; Pennsylvania; Persons; Prevention; Public Health; Recruitment Activity; Reporting; Research; Research Institute; Severities; Site; Solutions; Staging; Training; Universities; Variant; Work; World Health Organization; data management; evidence base; falls; field study; life history; medical schools; next generation; novel; programs; tool; transmission process; vector; vector mosquito

DESCRIPTION (provided by applicant): In India, the world's largest democracy and second most populous country, malaria remains an enormous public health problem. The National Institute of Malaria Research (NIMR) in New Delhi is the only institute in India dedicated to finding short- and long-term solutions to the problem of malaria through basic, applied, and operational field research. The Center for the Study of Complex Malaria in India (CSCMi) will bring together a group of leading US experts in the fields of malaria parasite research to work in tandem with faculty at the NIMR. Malaria in India is 'complex'; two predominant species of parasite infect almost equal numbers of people, and may be present serially or concurrently in one person. Each species also has multiple strains (genotypes) that can serially or concurrently infect. Indian malaria complexity, its variation by location, and its consequences for malaria severity and transmission, are the research focus of the CSCMi, which aims to develop the knowledge, tools, and evidence-based strategies needed to support the intervention and control programs of Indian government organizations, and to build research capacity in India and help train its next generation of malaria and mosquito vector biologists. CSCMi research comprises three Projects: 1) Epidemiology, 2) Transmission, and 3) Pathology and Diagnosis. Project 1 will rely on multiple blood samples from 3000 (1000 x 3) longitudinally-tracked individuals, both symptomatic and asymptomatic for different malarias, recruited at three ecologically and epidemiologically diverse NIMR field sites. It will assess how infection complexity, parasite diversity, and transmission rate impact immunity. Project 2 will investigate ecological and evolutionary determinants of malaria transmission, and the efficacy of novel evolution-proof bio-insecticides for disrupting transmission of simple and complex malaria. Project 3 will deploy next-generation genomics to study multiplicity of infection and the rise of antimalarial drug-resistant clones, and to develop a diagnostic test for drug-resistant parasites. CSCMi projects will be supported by Administrative, Data Management, and Genomics Cores to be located at the NIMR's new facility in Dwarka, New Delhi.

描述（由申请人提供）：在印度，是世界上最大的民主国家和第二大人口的国家，疟疾仍然是一个巨大的公共卫生问题。新德里的国家疟疾研究所（NIMR）是印度唯一致力于通过基本，应用和运营现场研究来解决疟疾问题的短期和长期解决方案的研究所。印度复杂疟疾研究中心（CSCMI）将汇集一群疟疾寄生虫研究领域的美国领先专家，与NIMR的教职员工合作。印度的疟疾是“复杂的”；两种主要的寄生虫感染几乎相等的人，并且可能在一个人中串行或同时存在。每个物种还具有多种菌株（基因型），可以连续或同时感染。印度疟疾的复杂性，逐个位置的变化及其对疟疾严重程度和传播的后果是CSCMI的研究重点，该研究重点旨在开发支持印度政府组织的干预和控制计划所需的知识，工具和基于证据的策略，并在印度建立研究能力，并帮助培训其下一代Malaria和Masquito Vector Vector Biologists。 CSCMI研究包括三个项目：1）流行病学，2）传播和3）病理学和诊断。项目1将依靠3000（1000 x 3）的多个血液样本，无论是有症状还是无症状的不同疟疾，在三个生态和流行病学上多样化的NIMR场地都招募。它将评估感染的复杂性，寄生虫多样性和传播率如何影响免疫力。项目2将研究疟疾传播的生态和进化决定因素，以及新颖的防止进化生物启示剂在破坏简单和复杂疟疾的传播方面的疗效。项目3将部署下一代基因组学来研究感染的多重性和抗药性药物克隆的兴起，并开发耐药寄生虫的诊断测试。 CSCMI项目将得到行政，数据管理和基因组核心的支持，该项目位于NIMR的新德里Dwarka的新工厂。