Administrative Core

行政核心

基本信息

批准号：
10117095
负责人：
Robert E. Lewis
金额：
$ 79.33万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-03-16 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10117095
关键词：
Advisory Committees Biology Biotechnology Clinical Communication Complex Data Analyses Detection Development Development Plans Disease Drug Industry Effectiveness Ensure Environment Etiology Experimental Designs Faculty Fostering Funding Generations Goals Grant Health Human Infrastructure Investments Laboratories Lead Leadership Mentors Mission Molecular Molecular Target Nebraska Outcome Performance Pilot Projects Pre-Clinical Model Procedures Program Research Project Grants Reporting Research Research Personnel Research Project Grants Resources Scientist Secure Series Students System Talents Teacher Professional Development Training Training Support Universities Update Validation Work career career development cohort design experience experimental study human disease improved innovation interest knowledge translation member novel strategies programs recruit senior faculty skills small molecule tool voucher

项目摘要

Project Summary/Abstract: Administrative Core The Administrative Core for the Nebraska Center for Molecular Target Discovery and Development will lead, implement, and support the Center's primary activities. These activities include creation of critical infrastructure for the (1) identification of disease targets, (2) generation of small molecules that manipulate those targets, and (3) analysis of preclinical models in which to evaluate the manipulation of those targets. Creation of that infrastructure will facilitate the Center's goal to deliver training and mentoring to promising new investigators focused on the discovery of new approaches that improve the treatment of disease. The Administrative Core will provide the organizational and programmatic leadership necessary to ensure the Center works efficiently toward attaining its goal, and is responsive to emerging research opportunities that improve its effectiveness. This will include implementing Center-wide activities – including an annual retreat, formal and informal training, and support for external seminar speakers – to create a collaborative research environment, promote the Center on a national level, and build a pool of talented doctoral and postdoctoral students in the laboratories of Center members. The Administrative Core will coordinate a faculty development plan that includes a Research Project Program and Pilot Grant Program designed to accelerate the transition of talented Project Leaders to independence and support the development of multi-investigator grants and program projects. Finally, the Administrative Core will serve as a coordination point between Center members and the Center's Scientific Cores. The Administrative Core will support a research program and related scientific cores to develop innovative tools for the detection and validation of molecular targets and provide guidance in experimental design and data analysis.

项目摘要/摘要：行政核心内布拉斯加州分子目标发现与发展中心的行政核心将领导实施并支持该中心的主要活动。这些活动包括建立关键基础设施对于（1）鉴定疾病靶标，（2）操纵这些靶标的小分子的产生，以及（3）分析临床前模型，其中评估这些目标的操纵。创建基础设施将促进该中心的目标，将培训和心理训练提供给有前途的新调查人员专注于发现改善疾病治疗的新方法。行政核心将提供必要的组织和程序领导，以确保中心有效地工作实现其目标，并对提高其有效性的新兴研究机会做出反应。这将包括实施中央范围的活动 - 包括年度务虚会，正式和非正式培训，并支持外部的准扬声器 - 创建协作研究环境，促进集中在国家一级，并在实验室中建立一群才华横溢的博士和博士后学生中心成员。行政核心将协调一项包括研究的教师发展计划项目计划和试点赠款计划，旨在加快才华横溢的项目负责人的过渡到独立并支持多投资者赠款和计划项目的发展。最后，行政核心将成为中心成员与中心科学之间的协调点内核。行政核心将支持研究计划和相关的科学核心发展用于检测和验证分子靶标的创新工具，并在实验中提供指导设计和数据分析。