Administrative Core

行政核心

• 批准号: 10747154
• 负责人: LONNY R LEVIN
• 金额: $ 25.12万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-10 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747154
• 关键词: Adenylate Cyclase; Advisory Committees; Affect; Animal Model; Biochemistry; Biological Availability; Biotechnology; Characteristics; Chemicals; Communication; Computer Models; Contraceptive Agents; Contraceptive methods; Crystallography; Data; Drug Kinetics; Elements; Ensure; Enzymatic Biochemistry; Evaluation; Fertilization; Fostering; Funding; Goals; Human; Human Resources; Infertility; Institution; Institutional Review Boards; Investigational New Drug Application; Lead; Link; Maintenance; Male Contraceptive Agents; Marketing; Medicine; Mus; National Institute of Child Health and Human Development; Oral; Oral Contraceptives; Partner in relationship; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacology; Physiology; Positioning Attribute; Principal Investigator; Property; Quality Control; Reproductive Biology; Research; Research Activity; Research Personnel; Resources; Series; Sperm Motility; Structure; Therapeutic; Time; Work; contraceptive efficacy; design; drug development; drug discovery; drug quality; early phase clinical trial; improved; in vivo; inhibitor; male; mating behavior; member; men; outreach; pharmacodynamic biomarker; pharmacologic; pill; preclinical development; preference; prevent; programs; recruit; scaffold; sperm cell; structural biology; tool; Adenylate Cyclase; Advisory Committees; Affect; Animal Model; Biochemistry; Biological Availability; Biotechnology; Characteristics; Chemicals; Communication; Computer Models; Contraceptive Agents; Contraceptive methods; Crystallography; Data; Drug Kinetics; Elements; Ensure; Enzymatic Biochemistry; Evaluation; Fertilization; Fostering; Funding; Goals; Human; Human Resources; Infertility; Institution; Institutional Review Boards; Investigational New Drug Application; Lead; Link; Maintenance; Male Contraceptive Agents; Marketing; Medicine; Mus; National Institute of Child Health and Human Development; Oral; Oral Contraceptives; Partner in relationship; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacology; Physiology; Positioning Attribute; Principal Investigator; Property; Quality Control; Reproductive Biology; Research; Research Activity; Research Personnel; Resources; Series; Sperm Motility; Structure; Therapeutic; Time; Work; contraceptive efficacy; design; drug development; drug discovery; drug quality; early phase clinical trial; improved; in vivo; inhibitor; male; mating behavior; member; men; outreach; pharmacodynamic biomarker; pharmacologic; pill; preclinical development; preference; prevent; programs; recruit; scaffold; sperm cell; structural biology; tool

Administrative Core The objective of the Administrative Core is to link together the various elements of the Weill Cornell Medicine Contraception Research Center (WCM-CRC). This center, titled “On-demand nonhormonal male contraception via ADCY10 inhibition,” has a singular scientific theme; to identify the safest and most efficacious means for blocking soluble adenylyl cyclase (sAC; ADCY10) in vivo to achieve an on-demand contraceptive pill for men. To achieve this goal, the WCM-CRC leverages the established inter-disciplinary team comprised of expertise in sAC physiology, pharmacology, biochemistry, reproductive biology, structural biology, enzymology, computational modeling, medicinal chemistry, and drug development. This team, which has been effectively and efficiently working together for the past 4 years, successfully advanced sAC inhibitors into potent, specific, drug-like leads that demonstrated proof-of-concept for on- demand male contraception in vivo in mice. This administrative core mirrors the successful administrative core from the previously funded WCM-CRC; all personnel and operational resources are maintained. Due to the advancements made over the past four years, the WCM-CRC investigative team joined forces with an expert in reproductive biology and an expert in contraceptive marketing and end-user preferences to form Sacyl Pharmaceuticals, Inc. (SACYL), a biotech company established to further develop and market sAC inhibitors as nonhormonal, on-demand birth control pills for men. SACYL will provide `Pharma-quality' drug development expertise to augment the work proposed in this application. In addition to ensuring that the established group of collaborators comprising the WCM-CRC functions as a single entity, the WCM- CRC Administrative Core will be responsible for maintaining complementarity between the WCM-CRC and SACYL as well as fostering interactions between the WCM-CRC and NICHD program personnel, investigators in other CRCs, and regulatory agencies. The Core's administrative responsibilities include planning, flow of information, developing resources, outreach, and overall administration for the WCM- CRC. In practice, the WCM-CRC Administrative Core will provide structure and oversight for the already existing relationships between the two co-Principal Investigators, the other project leaders, SACYL, and the Center's advisory committees.

行政核心 行政核心的目的是将Weill Cornell的各个元素链接在一起 医学避孕研究中心（WCM-CRC）。这个中心，标题为“按需非激男性男性 通过adcy10抑制作用，“具有一个单一的科学主题；以确定最安全，最安全的科学主题 在体内阻止固体腺苷酸环化酶（SAC; adcy10）的简单方法以实现按需 男性的避孕药。为了实现这一目标，WCM-CRC利用已建立的跨学科 团队完成了SAC生理学，药理学，生物化学，繁殖生物学专业知识， 结构生物学，酶学，计算建模，医学化学和药物开发。这 在过去的四年中，团队一直有效，有效地合作，成功地 晚期SAC抑制剂分解为潜在的，特异性的药物样铅，证明了概念概念 在小鼠体内需要男性避孕。这个管理核心反映了成功的管理 先前资助的WCM-CRC的核心；维持所有人员和运营资源。到期的 对于过去四年的进步，WCM-CRC调查小组与 生殖生物学专家，以及避孕营销和最终用户偏好专家 Sacyl Pharmaceuticals，Inc。（Sacyl），一家旨在进一步开发和营销的生物技术公司 SAC抑制剂是男性的非激素，按需避孕药。 Sacyl将提供“药品质量” 药物开发专业知识以增加本应用程序中提出的工作。除了确保 完成WCM-CRC的既定合作者团队作为一个实体，WCM- CRC行政核心将负责维持WCM-CRC和 Sacyl以及WCM-CRC和NICHD计划人员之间的互动， 其他CRC和监管机构的研究人员。核心的管理职责包括 计划，信息流，开发资源，外展和整体管理WCM- CRC。实际上，WCM-CRC行政核心将为已经 两位联合主要研究人员，其他项目负责人，Sacyl和 该中心的咨询委员会。