Nebraska Center for Molecular Target Discovery and Development

内布拉斯加州分子靶标发现和开发中心

基本信息

批准号：
10392932
负责人：
Robert E. Lewis
金额：
$ 227.02万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-03-16 至 2023-07-19
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10392932
关键词：
Appointment Area Award Awareness Basic Science Belief Bioinformatics Biology Biomedical Research Career Mobility Centers of Research Excellence Chemicals Clinical Collaborations Communities Development Discipline Disease Epigenetic Process Extramural Activities Faculty Financial Support Future Genomics Goals Grant Health Human Image In Vitro Infrastructure Institution Investments Knowledge Mass Spectrum Analysis Medical center Mentors Modernization Molecular Molecular Analysis Molecular Target Nebraska Pre-Clinical Model RNA Interference RNA interference screen Reagent Research Research Personnel Research Support Resource Development Resource Sharing Resources System Teacher Professional Development Therapeutic Training Universities Validation Vision bench to bedside career college computational chemistry cost experience genetic analysis genome sequencing high throughput screening improved in vivo insight interest man member new therapeutic target novel lead compound novel therapeutics operation preclinical development programs screening skills small molecule targeted treatment therapeutic development therapeutic target translational research program undergraduate research undergraduate student

项目摘要

Project Summary/Abstract: Overall Center Organization and Management Plan The goal of the Nebraska Center for Molecular Target Discovery and Development is to establish and expand physical and intellectual resources at the University of Nebraska Medical Center (UNMC) and the University of Nebraska system that will catalyze the ability of its faculty to define, validate, and develop potential therapies against molecular targets for clinically important diseases. The Center aims to maximize investment from both the COBRE award and UNMC to enhance the research capabilities of the Institution, expand the translational capabilities of its faculty, facilitate career advancement of promising junior faculty in the area of targeted therapeutics, and efficiently drive discovery and development for the improvement of human health in Nebraska and the nation. This Center will (1) create critical infrastructure for the discovery and validation of molecular effectors critical to the development of disease and (2) deliver training and mentoring to promising new investigators willing and able to use that infrastructure to validate those effectors as therapeutic targets, identify small molecules for their manipulation, and create in vitro and in vivo preclinical models for their development as novel therapies. Center investigators bring a breadth of cutting edge expertise necessary to accomplish this vision. They share a common belief that many diseases can be effectively classified and characterized through detailed genomic, genetic, and molecular analyses to identify drivers and vulnerabilities from which will emerge unique therapeutic approaches. To realize this shared vision, the Center and its investigators will: 1) Establish an Administrative Core and mentoring programs to support and enhance research in target discovery and development; 2) Establish a critical mass of investigators focused on the identification, validation and development of therapeutic targets for disease treatment; and 3) Increase research capacity through scientific cores for high throughput chemical, RNAi and computational screening; mass spectrometry; and target validation.

项目摘要/摘要：总体中心组织和管理计划内布拉斯加州分子目标发现与发展中心的目标是建立和扩展内布拉斯加州大学医学中心（UNMC）和大学的物理和智力资源内布拉斯加州系统将催化其教师定义，验证和开发潜在疗法的能力针对临床上重要疾病的分子靶标。该中心旨在最大化两者的投资 COBRE奖和UNMC旨在增强机构的研究能力，扩大翻译其教师的能力，促进了目标领域有前途的初级教师的职业发展治疗剂，并有效地推动发现和发展，以改善人类健康内布拉斯加州和国家。该中心将（1）为发现和验证创建关键的基础架构分子效应子对疾病发展至关重要，（2）提供培训和指导新的研究人员愿意并且能够使用该基础设施来验证这些效应子作为治疗靶标，识别小分子的操作，并为其创建体外和体内临床前模型发展为新疗法。中心调查人员带来了必要的尖端专业知识实现这一愿景。他们有一个共同的信念，即许多疾病可以有效地分类，并且通过详细的基因组，遗传和分子分析来识别驱动因素和漏洞从中将出现独特的治疗方法。为了实现这种共同的愿景，中心及其调查人员将：1）建立一个行政核心和指导计划，以支持和增强目标发现和发展方面的研究； 2）建立关注的调查员鉴定，验证和开发用于疾病治疗的治疗靶标； 3）增加通过科学核心进行研究能力，用于高通量化学，RNAi和计算筛选；质谱；和目标验证。