Environmental Challenges and the Aging Brain: Implications for Community Mobility

环境挑战和大脑老化：对社区流动性的影响

• 批准号: 10117714
• 负责人: Andrea L Rosso
• 金额: $ 2.01万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10117714
• 关键词: Accelerometer; Affect; Age; Anxiety; Attention; Brain; Brain imaging; Characteristics; Clinical assessments; Cognitive aging; Communities; Complex; Congenital neurologic anomalies; Device or Instrument Development; Diffusion Magnetic Resonance Imaging; Elderly; Environment; Future; Gait; Goals; Healthcare; Home environment; Image; Impairment; Independent Living; Individual; Intervention; K-Series Research Career Programs; Laboratories; Leadership; Left; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Mediation; Methodology; Monitor; Movement; Near-Infrared Spectroscopy; Nervous System Physiology; Neuraxis; Participant; Performance; Peripheral; Prefrontal Cortex; Quality of life; Research; Research Design; Role; Structure; Testing; Time; Training; Walking; White Matter Hyperintensity; Wireless Technology; Work; age related; aging brain; base; body system; cognitive testing; cost; cost estimate; disability; executive function; falls; gray matter; improved; innovation; multimodality; nervous system disorder; neuroimaging; neuromechanism; novel; preservation; relating to nervous system; skills; social; standard measure; tool; walking speed; white matter; young adult

Mobility limitations are common and costly. Community mobility is an individual’s movement that occurs outside the home and occurs within complex environments. Therefore, the interactions of an individual with the environment must be considered to fully understand how mobility limitations arise. The association of subclinical central nervous system (CNS) abnormalities with mobility in older adults free from neurologic disease is beginning to be established but is typically not studied in relation to environmental challenges. The first aim of this proposal is to characterize the relation between CNS characteristics, peripheral contributors, and community- based environmental challenges in a group of community-dwelling older adults. The second aim will develop and validate lab-based environmental challenges that reflect performance in actual community environments. This proposal incorporates several innovations that will allow me to better assess how the aging brain affects negotiation of real-world environmental challenges: 1) use of community-based environmental challenges in the lab to test community mobility 2) use of wearable, wireless functional near-infrared spectroscopy (fNIRS) for assessment of functional brain changes while participants are walking and 3) a multimodal neuroimaging approach that combines functional measurements from fNIRS with structural imaging. To successfully complete this research, I propose four training aims: 1) Acquire skills in measurement of gait in the lab and the real world; 2) Become an expert in use of near-infrared spectroscopy in mobility research; 3) Acquire advanced skills in in instrument development and testing; and 4) Continue to develop leadership and professional skills. These training aims will help me to achieve my immediate goals of establishing the relation between brain aging and limitations in community mobility as well as my long term goals of better understanding the contributors to community mobility in order to inform future intervention strategies. This research will establish the association between CNS function and negotiation of community-based environmental challenges, will establish the validity of tools for use in future studies, and will provide evidence towards novel intervention strategies to improve community mobility of older adults.

流动性限制是普遍且昂贵的。社区流动性是个人的运动 发生在家庭外，发生在复杂的环境中。因此， 必须考虑具有环境的个人，以充分了解流动性 出现局限性。亚临床中枢神经系统（CNS）异常的关联 未经神经疾病的老年人的流动性开始建立，但 通常不研究与环境挑战有关。该提议的第一个目的是 表征CNS特征，外围贡献者和社区 - 在一群社区居住的老年人中，基于环境挑战。第二个目标 将发展并验证基于实验室的环境挑战，以反映实际的绩效 社区环境。该提案结合了几项创新，这将使我能够 更好地评估衰老大脑如何影响现实世界环境挑战的谈判：1） 在实验室中使用基于社区的环境挑战来测试社区流动性2）使用 可穿戴的无线功能近红外光谱（FNIRS）用于评估功能 参与者走路时的大脑变化和3）一种多模式的神经影像学方法 结合FNIRS的功能测量和结构成像。成功 完成这项研究，我提出了四个培训目的：1）获取步态测量的技能 实验室和现实世界； 2）成为移动性近红外光谱的专家 研究; 3）获得仪器开发和测试方面的先进技能； 4）继续 发展领导能力和专业技能。这些培训目标将帮助我实现 建立大脑衰老与社区局限性之间关系的直接目标 流动性以及我更好地了解社区贡献者的长期目标 流动性以告知未来的干预策略。这项研究将确定 CNS功能与基于社区环境的谈判之间的关联 挑战将确定工具在未来研究中使用的有效性，并将提供证据 采取新颖的干预策略，以改善老年人的社区流动性。

项目成果

Uneven surface and cognitive dual-task independently affect gait quality in older adults.

不平坦的表面和认知双重任务独立影响老年人的步态质量。

• DOI: 10.1016/j.gaitpost.2023.08.010
• 发表时间: 2023
• 期刊: Gait & posture
• 影响因子: 2.4
• 作者: Suri,Anisha;VanSwearingen,Jessie;Rosano,Caterina;Brach,JenniferS;Redfern,MarkS;Sejdić,Ervin;Rosso,AndreaL
• 通讯作者: Rosso,AndreaL

The Effect of a Verbal Cognitive Task on Postural Sway Does Not Persist When the Task Is Over.

• DOI: 10.3390/s21248428
• 发表时间: 2021-12-17
• 期刊: Sensors (Basel, Switzerland)
• 作者: Bohlke K;Zhu X;Sparto PJ;Redfern MS;Rosano C;Sejdic E;Rosso AL
• 通讯作者: Rosso AL

Facilitators and barriers to real-life mobility in community-dwelling older adults: a narrative review of accelerometry- and global positioning system-based studies.

• DOI: 10.1007/s40520-022-02096-x
• 发表时间: 2022-08
• 期刊: Aging clinical and experimental research
• 影响因子: 4
• 作者: Suri A;VanSwearingen J;Dunlap P;Redfern MS;Rosso AL;Sejdić E
• 通讯作者: Sejdić E

Interrater Reliability of Historical Virtual Audits Using Archived Google Street View Imagery.

• DOI: 10.1123/japa.2019-0331
• 发表时间: 2021-02-01
• 期刊: JOURNAL OF AGING AND PHYSICAL ACTIVITY
• 影响因子: 1.5
• 作者: Harding, Alyson B.;Glynn, Nancy W.;Studenski, Stephanie A.;Clarke, Philippa J.;Divecha, Ayushi A.;Rosso, Andrea L.
• 通讯作者: Rosso, Andrea L.

Associations of neighborhood walkability and walking behaviors by cognitive trajectory in older adults.

• DOI: 10.1093/geront/gnab005
• 发表时间: 2021-01
• 期刊: The Gerontologist
• 作者: A. Rosso;Alyson B Harding;P. Clarke;S. Studenski;C. Rosano