Respiratory Effects of Exposure to Metals from Electronic Cigarettes (RE-EMIT)
接触电子烟金属对呼吸系统的影响 (RE-EMIT)
基本信息
- 批准号:10115962
- 负责人:
- 金额:$ 18.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-20 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AerosolsAffectAir MovementsAntimonyArsenicBehaviorBiological MarkersBloodCadmiumCarbon MonoxideChemicalsChromiumCotinineDataDevicesDiffuseDisease OutbreaksElectronic cigaretteExhalationExposure toForced expiratory volume functionFutureGoalsHealthHeatingInfrastructureInhalationInstitutional Review BoardsInterventionKnowledgeLeadLightLungManganeseMeasuresMetal exposureMetalsModelingMonitorNickelNicotineOutcomeOutcome MeasureParentsParticipantPatientsPatternPolicy ResearchPrevalenceProcessPulmonary Function Test/Forced Expiratory Volume 1Pulmonary function testsQuestionnairesRegimenRegulationReproducibilityRespiratory physiologyRoleSmokerSourceSpirometryTestingTimeToxic effectToxicologyTungstenUrineVital capacityWorkYouthZincage differenceblood leadcohorte-cigarette aerosolselectronic cigarette useelectronic cigarette userelectronic liquidfallsmarijuana usemetallicityrecruitrespiratoryrespiratory healthsextoxic metaltoxicantvapervapingvaping associated lung injuryvaporyoung adult
项目摘要
Project Summary
The use of electronic cigarettes (e-cigs) has increased at an alarming rate among youth and young adults,
despite critical knowledge gaps on their toxicity and potential health effects. E-cig devices work by heating a
mixture of chemicals (e-liquid) with a metallic coil to generate a fine aerosol, which is inhaled by the user. Several
metals, including lead and nickel, have been found in e-cig aerosols and are known lung toxicants; however,
there is little information on how patterns of e-cig use impact exposure to metals and how these metal exposures
may be associated with pulmonary health effects. In addition, despite the FDA's partial ban on flavored e-
cigarettes, a new type of disposable e-cig (e.g. Puff Bar) has been recently introduced in the market targeting
youth and young adults with sweet and fruity flavors; thus, we would like to evaluate how the use of these new
devices affects exposure to metals and lung function. The recent e-cigarette, or vaping, product use-associated
lung injury (EVALI) outbreak underscores the need to study how e-cig use may be associated with respiratory
outcomes. Spirometry, a reproducible test of pulmonary lung function (PFT), allows assessment of early airway
obstructive or restrictive processes. We hypothesize 1) new disposable e-cigs on the market (i.e. puff bars) are
also a source of metal exposure, 2) e-cig user's vaping regimen affects the degree of metal exposure, and 3)
that toxic metal exposure can have negative effects on respiratory health outcomes measured through
reproducible pulmonary function tests, such as spirometry. Thus, our specific aims are 1) to measure metal
exposure from new and emerging e-cig devices, 2) evaluate the association of e-cig use with pulmonary health
measures, and 3) to assess the potential for metals from e-cigs to explain, at least in part, the measured
pulmonary health effects. To achieve our goal, we will add pulmonary outcome measures to the remaining 25
POD e-cig users and 25 control participants from our R01. We will recruit an additional 25 e-cigs users of new
disposable e-cigs (including Puff Bars) and 25 matched non-users to characterize pulmonary outcomes
(Reductions in the forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and diffusing
capacity of carbon monoxide (DLCO)), measures of metals in aerosol from their devices, and measures of
internal exposure to metals in urine and blood at 0 and 6 months. We will verify e-cig use by urine cotinine and
potential tetrahydrocannabinol (THC) use by urine toxicology test. Policy and research impact: In light of the
recent EVALI outbreak, and the proliferation of new flavored disposable e-cig devices, there is an urgent need
to understand exposures resulting from these devices. This study will generate critical data to inform FDA for e-
cig regulation targeted at curbing the increasing prevalence use among youth and young adults, as well as to
plan future interventions to limit adverse exposures and health outcomes.
项目概要
青少年和年轻人中电子烟(e-cigs)的使用以惊人的速度增加,
尽管对其毒性和潜在健康影响存在严重的认识差距。电子烟设备的工作原理是加热
化学物质(电子液体)与金属线圈的混合物,产生细小的气雾,被用户吸入。一些
电子烟气溶胶中发现了铅和镍等金属,它们是已知的肺部毒物;然而,
关于电子烟的模式如何使用影响金属暴露以及这些金属暴露如何的信息很少
可能与肺部健康影响有关。此外,尽管 FDA 部分禁止调味电子产品
香烟,最近在市场上推出了一种新型一次性电子烟(例如 Puff Bar)
青少年和年轻人,具有甜味和果味;因此,我们想评估如何使用这些新的
设备会影响金属接触和肺功能。最近与电子烟或电子烟产品使用相关的
肺损伤(EVALI)的爆发强调需要研究电子烟的使用与呼吸系统之间的关系
结果。肺活量测定法是一种可重复的肺功能 (PFT) 测试,可以评估早期气道
阻碍性或限制性的过程。我们假设 1) 市场上新的一次性电子烟(即烟棒)是
也是金属暴露的一个来源,2) 电子烟用户的吸电子烟习惯会影响金属暴露的程度,3)
有毒金属暴露会对呼吸系统健康结果产生负面影响
可重复的肺功能测试,例如肺活量测定。因此,我们的具体目标是 1) 测量金属
来自新兴电子烟设备的暴露,2) 评估电子烟使用与肺部健康的关联
措施,以及 3) 评估电子烟中金属的潜力,以至少部分解释测量的结果
肺部健康影响。为了实现我们的目标,我们将在其余 25 个项目中添加肺部结果测量
POD 电子烟用户和来自我们 R01 的 25 名对照参与者。我们将另外招募 25 名新电子烟用户
一次性电子烟(包括烟棒)和 25 名匹配的非使用者来描述肺部结果
(一秒用力呼气量 (FEV1)、用力肺活量 (FVC) 和弥散量的减少
一氧化碳(DLCO)的容量),其设备中气溶胶中金属的测量,以及
0 个月和 6 个月时体内暴露于尿液和血液中的金属。我们将通过尿液可替宁和
通过尿液毒理学测试发现潜在的四氢大麻酚(THC)使用。政策和研究影响:鉴于
最近EVALI疫情爆发,以及新口味一次性电子烟设备的激增,迫切需要
了解这些设备造成的暴露。这项研究将生成关键数据,以通知 FDA 进行电子-
香烟监管旨在遏制青少年和年轻人中日益流行的使用香烟,并
规划未来的干预措施,以限制不良暴露和健康结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Ana Maria Rule', 18)}}的其他基金
The Exposure to Metals from E-Cigarettes (EMIT) Study
电子烟中的金属暴露 (EMIT) 研究
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$ 18.81万 - 项目类别:
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