Respiratory Effects of Exposure to Metals from Electronic Cigarettes (RE-EMIT)
接触电子烟金属对呼吸系统的影响 (RE-EMIT)
基本信息
- 批准号:10115962
- 负责人:
- 金额:$ 18.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-20 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AerosolsAffectAir MovementsAntimonyArsenicBehaviorBiological MarkersBloodCadmiumCarbon MonoxideChemicalsChromiumCotinineDataDevicesDiffuseDisease OutbreaksElectronic cigaretteExhalationExposure toForced expiratory volume functionFutureGoalsHealthHeatingInfrastructureInhalationInstitutional Review BoardsInterventionKnowledgeLeadLightLungManganeseMeasuresMetal exposureMetalsModelingMonitorNickelNicotineOutcomeOutcome MeasureParentsParticipantPatientsPatternPolicy ResearchPrevalenceProcessPulmonary Function Test/Forced Expiratory Volume 1Pulmonary function testsQuestionnairesRegimenRegulationReproducibilityRespiratory physiologyRoleSmokerSourceSpirometryTestingTimeToxic effectToxicologyTungstenUrineVital capacityWorkYouthZincage differenceblood leadcohorte-cigarette aerosolselectronic cigarette useelectronic cigarette userelectronic liquidfallsmarijuana usemetallicityrecruitrespiratoryrespiratory healthsextoxic metaltoxicantvapervapingvaping associated lung injuryvaporyoung adult
项目摘要
Project Summary
The use of electronic cigarettes (e-cigs) has increased at an alarming rate among youth and young adults,
despite critical knowledge gaps on their toxicity and potential health effects. E-cig devices work by heating a
mixture of chemicals (e-liquid) with a metallic coil to generate a fine aerosol, which is inhaled by the user. Several
metals, including lead and nickel, have been found in e-cig aerosols and are known lung toxicants; however,
there is little information on how patterns of e-cig use impact exposure to metals and how these metal exposures
may be associated with pulmonary health effects. In addition, despite the FDA's partial ban on flavored e-
cigarettes, a new type of disposable e-cig (e.g. Puff Bar) has been recently introduced in the market targeting
youth and young adults with sweet and fruity flavors; thus, we would like to evaluate how the use of these new
devices affects exposure to metals and lung function. The recent e-cigarette, or vaping, product use-associated
lung injury (EVALI) outbreak underscores the need to study how e-cig use may be associated with respiratory
outcomes. Spirometry, a reproducible test of pulmonary lung function (PFT), allows assessment of early airway
obstructive or restrictive processes. We hypothesize 1) new disposable e-cigs on the market (i.e. puff bars) are
also a source of metal exposure, 2) e-cig user's vaping regimen affects the degree of metal exposure, and 3)
that toxic metal exposure can have negative effects on respiratory health outcomes measured through
reproducible pulmonary function tests, such as spirometry. Thus, our specific aims are 1) to measure metal
exposure from new and emerging e-cig devices, 2) evaluate the association of e-cig use with pulmonary health
measures, and 3) to assess the potential for metals from e-cigs to explain, at least in part, the measured
pulmonary health effects. To achieve our goal, we will add pulmonary outcome measures to the remaining 25
POD e-cig users and 25 control participants from our R01. We will recruit an additional 25 e-cigs users of new
disposable e-cigs (including Puff Bars) and 25 matched non-users to characterize pulmonary outcomes
(Reductions in the forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and diffusing
capacity of carbon monoxide (DLCO)), measures of metals in aerosol from their devices, and measures of
internal exposure to metals in urine and blood at 0 and 6 months. We will verify e-cig use by urine cotinine and
potential tetrahydrocannabinol (THC) use by urine toxicology test. Policy and research impact: In light of the
recent EVALI outbreak, and the proliferation of new flavored disposable e-cig devices, there is an urgent need
to understand exposures resulting from these devices. This study will generate critical data to inform FDA for e-
cig regulation targeted at curbing the increasing prevalence use among youth and young adults, as well as to
plan future interventions to limit adverse exposures and health outcomes.
项目摘要
电子烟(电子烟)的使用以令人震惊的年轻人和年轻人的惊人速度增加,
尽管知识差距差异,但其毒性和潜在的健康影响。电子烟设备通过加热来工作
化学物质(电子液体)与金属线圈的混合物,以产生高的气溶胶,该气溶胶被用户吸入。一些
金属(包括铅和镍)已在E-cig气溶胶中发现,是已知的肺有毒物质。然而,
关于电子烟的模式如何使用对金属的影响以及这些金属暴露方式几乎没有信息
可能与肺部健康作用有关。此外,尽管FDA部分禁止了调味的E-
卷烟是一种新型的一次性电子烟(例如泡芙酒吧),最近在市场中引入了
青年和年轻人具有甜美和果味的口味;因此,我们想评估如何使用这些新的
设备会影响接触金属和肺功能。最近的电子烟或烟与产品相关的
肺损伤(EDATI)暴发强调了研究如何使用电子烟与呼吸有关的需求
结果。肺活量测定法是肺肺功能(PFT)的可再现测试,允许评估早期呼吸道
阻塞性或限制性过程。我们假设1)市场上新的一次性电子烟(即泡芙酒吧)是
也是金属曝光的来源2)电子烟用户的蒸气方案会影响金属暴露的程度,3)
有毒金属暴露会对通过
可再现的肺功能测试,例如肺活量测定法。因此,我们的具体目的是1)测量金属
从新的和新兴的电子烟设备接触,2)评估电子烟与肺部健康的关联
措施和3)评估电子烟的金属的潜力至少部分解释了
肺部健康影响。为了实现我们的目标,我们将添加肺癌结果指标
POD E-cig用户和我们R01的25个对照参与者。我们将招募新的25个新的电子烟用户
一次性电子烟(包括泡芙杆)和25种匹配的非用户,以表征肺结果
(在一秒钟(FEV1),强制生命力(FVC)中减少强制呼气量并扩散
一氧化碳(DLCO)的容量,其设备中气溶胶中金属的量度以及量度
内部暴露于0和6个月时尿液和血液中的金属。我们将验证尿cotinine和
潜在的四氢大麻酚(THC)通过尿液毒理学测试。政策和研究影响:鉴于
最近的评估爆发以及新调味的一次性电子烟设备的扩散,迫切需要
了解这些设备引起的暴露。这项研究将生成关键数据,以告知FDA以获得电子
CIG监管旨在遏制青年和年轻人的患病率增加以及
计划未来的干预措施,以限制不良暴露和健康成果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ana Maria Rule其他文献
Ana Maria Rule的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ana Maria Rule', 18)}}的其他基金
The Exposure to Metals from E-Cigarettes (EMIT) Study
电子烟中的金属暴露 (EMIT) 研究
- 批准号:
9788464 - 财政年份:2018
- 资助金额:
$ 18.81万 - 项目类别:
Development of New Generation Gas and Vapor Sensors Using Organic Electronics
使用有机电子器件开发新一代气体和蒸汽传感器
- 批准号:
8527548 - 财政年份:2012
- 资助金额:
$ 18.81万 - 项目类别:
相似国自然基金
海洋缺氧对持久性有机污染物入海后降解行为的影响
- 批准号:42377396
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
氮磷的可获得性对拟柱孢藻水华毒性的影响和调控机制
- 批准号:32371616
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
还原条件下铜基催化剂表面供-受电子作用表征及其对CO2电催化反应的影响
- 批准号:22379027
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
CCT2分泌与内吞的机制及其对毒性蛋白聚集体传递的影响
- 批准号:32300624
- 批准年份:2023
- 资助金额:10 万元
- 项目类别:青年科学基金项目
在轨扰动影响下空间燃料电池系统的流动沸腾传质机理与抗扰控制研究
- 批准号:52377215
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
相似海外基金
Mitigation of ventilation-based resuspension and spread of airborne viruses in nosocomial and healthcare settings
减轻医院和医疗机构中基于通气的空气传播病毒的再悬浮和传播
- 批准号:
10668064 - 财政年份:2023
- 资助金额:
$ 18.81万 - 项目类别:
Dynamic, Cellularized, 3D Printed Model Development for Aerosol Targeting in Pediatric JORRP Patients
用于儿科 JORRP 患者气溶胶靶向的动态、细胞化、3D 打印模型开发
- 批准号:
10317899 - 财政年份:2021
- 资助金额:
$ 18.81万 - 项目类别:
Dynamic, Cellularized, 3D Printed Model Development for Aerosol Targeting in Pediatric JORRP Patients
用于儿科 JORRP 患者气溶胶靶向的动态、细胞化、3D 打印模型开发
- 批准号:
10514527 - 财政年份:2021
- 资助金额:
$ 18.81万 - 项目类别:
Novel Device to Optimize Aerosol Drug Delivery for Pulmonary Hypertension Treatment
优化肺动脉高压治疗气雾剂药物输送的新型装置
- 批准号:
10698474 - 财政年份:2020
- 资助金额:
$ 18.81万 - 项目类别:
A mechanism-based computational toolkit to optimize age-specific pediatric pulmonary drug delivery
基于机制的计算工具包,用于优化特定年龄的儿科肺部药物输送
- 批准号:
9909367 - 财政年份:2020
- 资助金额:
$ 18.81万 - 项目类别: