Biostatistics and Bioinformatics Core (Shared Resources

生物统计学和生物信息学核心（共享资源

• 批准号: 10015232
• 负责人: Eric Andrew Ross
• 金额: $ 12.97万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10015232
• 关键词: Achievement; Behavior; Bioinformatics; Biometry; Biostatistics Core; Cancer Biology; Cancer Control Research; Chromosomes; Clinical; Clinical Informatics; Clinical Investigator; Clinical Trials; Collaborations; Computers; Computing Methodologies; Consultations; Cytogenetic Analysis; DNA sequencing; Data; Data Analyses; Data Storage and Retrieval; Database Management Systems; Development; Doctor of Philosophy; Environment; Epidemiologist; Epidemiology; Epigenetic Process; Experimental Designs; Fostering; Future; Genomics; Goals; Guidelines; Health Insurance Portability and Accountability Act; Informatics; Information Systems; Infrastructure; Institution; Institutional Review Boards; Internet; Knowledge; Malignant Neoplasms; Manuscripts; Methods; Nature; Participant; Phase; Pilot Projects; Play; Population Sciences; Postdoctoral Fellow; Procedures; Randomized; Research; Research Design; Research Personnel; Research Project Grants; Research Proposals; Resource Sharing; Resources; Retrieval; Role; Running; Sample Size; Scientist; Services; Statistical Computing; Statistical Data Interpretation; Structure; System; Writing; anticancer research; base; bioinformatics tool; cancer education; cancer health disparity; cancer prevention; clinical application; cost effective; data access; data analysis pipeline; data management; data pipeline; data sharing; design; diverse data; electronic data; experience; experimental study; genetic epidemiology; genomic data; genomic epidemiology; high throughput analysis; informatics tool; member; multidisciplinary; next generation sequencing; preclinical study; skills; tool; transcriptome sequencing; user-friendly

PROJECT SUMMARY Biostatistics and Bioinformatics Core (Shared Resource) TUFCCC: Eric A. Ross, PhD (Co-Leader) HC: Konstantinos Krampis, PhD (Co-Leader) The overall goal of the Biostatistics and Bioinformatics Core (BBC) is to facilitate cancer disparities research at TUFCCC and HC by providing expert experimental design, bioinformatics, data management, genomics and data analysis support to TUFCCC/HC Cancer Partnership scientists. Members of the core have substantial knowledge and experience in biostatistics, bioinformatics, genomics and epidemiology as applied to cancer research. This highly interactive group of biostatisticians, bioinformatics, informaticians, geneticists and epidemiologists will serve all Partnership projects, pilot studies and cores and support future projects and pilot studies. The specific aims of the Biostatistics and Biostatistics Core are to: (1) Provide expert consultation for TUFCCC/HC Cancer Partnership investigators in the rigorous design of experiments and studies, including research proposal development, sample size determination, randomization procedures, experimental methods and plans for interim reviews and final analysis. (2) Perform statistical and bioinformatics analyses for TUFCCC/HC Cancer Partnership investigators using appropriate statistical and computing methodologies, as well as assist investigators with the writing of statistical and bioinformatics components of manuscripts and the interpretation and presentation of results. (3) Provide Informatics tools to enhance TUFCCC/HC Cancer Partnership research. Build cancer research capacity at HC by providing HC researchers with information systems that facilitate data entry, storage and retrieval. (4) Provide cost-effective, high-quality genomic and epigenetic services and expertise for the TUFCCC/HC Cancer Partnership including NextGen sequencing (e.g., DNA-Seq, RNA-Seq) as well cytogenetic analysis, chromosome and expression microarray solutions as needed. (5) Enable TUFCCC/HC investigators who may be non-technical users to easily access and manage large-scale genomic datasets and run bioinformatics data pipelines, through a user- friendly, web-browser accessible interface. By providing quantitative and genomics expertise and resources to investigators, and sharing technical capabilities, the BBC team will support the entire TUFCCC/HC Cancer Partnership and facilitate achievement of project aims and exploratory analyses beyond those stated.

项目摘要 生物统计学和生物信息学核心（共享资源） TUFCCC：Eric A. Ross，博士（共同领导）HC：Konstantinos Krampis，PhD（共同领导） 生物统计学和生物信息学核心（BBC）的总体目标是促进癌症 TUFCCC和HC的差异研究通过提供专家实验设计， 生物信息学，数据管理，基因组学和数据分析支持TUFCCC/HC癌症 伙伴关系科学家。核心成员在 生物统计学，生物信息学，基因组学和流行病学应用于癌症研究。这 高度互动的生物阶级主义者，生物信息学，知情者，遗传学家和 流行病学家将为所有伙伴关系项目，试点研究和核心服务，并支持未来 项目和试点研究。 生物统计学和生物统计学核心的具体目的是：（1）提供专家 TUFCCC/HC癌症伙伴关系研究人员的咨询 实验和研究，包括研究建议开发，样本量确定， 随机化程序，实验方法和临时审查的计划和最终的计划 分析。 （2）对TUFCCC/HC癌进行统计和生物信息学分析 合作伙伴研究人员使用适当的统计和计算方法以及 协助研究人员撰写统计和生物信息学组成部分的手稿 以及结果的解释和表现。 （3）提供信息工具来增强 TUFCCC/HC癌症伙伴关系研究。通过提供HC的癌症研究能力 HC研究人员具有促进数据输入，存储和检索的信息系统。 （4） 提供具有成本效益，高质量的基因组和表观遗传服务以及专业知识 TUFCCC/HC癌症伙伴关系包括NextGen测序（例如DNA-Seq，RNA-Seq） 根据需要进行良好的细胞遗传学分析，染色体和表达微阵列溶液。 （5） 启用可能是非技术用户的TUFCCC/HC调查人员，可以轻松访问和 通过用户管理大规模基因组数据集并运行生物信息学数据管道 友好的Web浏览器访问界面。 通过向调查人员提供定量和基因组学专业知识和资源，并分享 技术能力，英国广播公司将支持整个TUFCCC/HC癌症合作伙伴关系 并有助于实现项目目标和探索性分析。