Shared Resource: Population Studies Facility

共享资源：人口研究设施

基本信息

批准号：
9754603
负责人：
Eric Andrew Ross
金额：
$ 19.69万
依托单位：
RESEARCH INST OF FOX CHASE CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9754603
关键词：
Abbreviations Advisory Committees Behavioral Medicine Bioinformatics Biological Biometry Blood Cells Cancer Biology Cancer Center Cancer Center Support Grant Cancer Control Cell Culture Techniques Cell Separation Chemoprevention Clinical Clinical Research Clinical Research Associate Clinical Trials Cohort Studies Collaborations Collection Complex Comprehensive Cancer Center Computer software Computers Consult Consultations Custom Data Data Collection Databases Development Discipline Doctor of Philosophy Enrollment Ensure Environment Epigenetic Process Fox Chase Cancer Center Foxes Funding Generations Genomics Health system Histopathology Facility Hour Human Genetics Human Resources Informatics Information Systems Interleukin-6 International Laboratories Laboratory Animals Malignant Neoplasms Manuscripts Methods Molecular Molecular Epidemiology Multimedia NCI Center for Cancer Research Outcomes Research Parents Participant Patients Peer Review Population Study Protocols documentation Quality Control Questionnaires Recommendation Reporting Research Research Infrastructure Research Personnel Research Support Resource Sharing Resources Retrieval Services Software Design Software Engineering Software Tools Source Specimen System Therapeutic Transgenic Mouse Facility Translational Research Universities University Hospitals animal facility anticancer research base cancer information system cancer prevention computer science cost effective data exchange data management data warehouse electronic data epidemiology study high throughput screening imaging facilities informatics infrastructure informatics shared resource informatics tool medical schools member molecular modeling open source operation peer support programs recruit repository research study science teacher skills software development success tool web-enabled

项目摘要

COMPUTATIONAL/INFORMATICS SHARED RESOURCE: POPULATION STUDIES FACILITY (PSF) PROJECT SUMMARY/ABSTRACT PSF was rated "Outstanding" at the last review. Computer-based tools are vital to many research studies’ success, particularly those that collect large amounts of data or involve complex data collection protocols. The PSF facilitates FCCC research by providing critical informatics infrastructure and customized, project-specific information systems for Cancer Center members. PSF, with the direction of Eric Ross, PhD and a staff of 5.5 FTEs provides members with a stable, cost-effective team of information systems professionals with state-of- the-art software design and engineering skills appropriate to cancer research. PSF functions include development of: databases for the storage and manipulation of large quantities of questionnaire, clinical, molecular and specimen data; electronic data capture interfaces; report generation software; consistency and quality control systems; web-enabled multimedia applications; and systems that provide integration and controlled exchange of data from diverse sources. PSF is a critical component of the research infrastructure to which all Cancer Center members have ready access. PSF has developed systems that maintain data on over 210,000 subjects. More than 90,000 were enrolled in FCCC studies within the US; the remainder were in international cohort studies. PSF staff are proficient with software tools for managing complex databases and expert with methods employed by collaborating investigators. From 2011-2014, the PSF provided 32,596 consulting hours in support of 38 Cancer Center members in four Research Programs. It provided 7,125 consulting hours to 24 Cancer Center members in 2014. 6,380 of the consulting hours (90%) were in support of peer-review funded Cancer Center members. PSF provided direct informatics support to seven other FCCC CCSG-supported faciltiies during the current cycle. The PSF also collaborated with the Clinical Trials Office on deployment, customization and integration of new core informatics tools to support clinical research and associated regulatory functions. PSF expanded the Fox Chase Data Warehouse (FCDW) during the current cycle. It now integrates data from 41 research and clinical systems derived from 228,000 patients and study participants. The FCDW stimulates new collaborations and opportunities for translational and correlative research. From 2011 to June 2015, the PSF contributed to 117 manuscripts, of which PSF personnel are co-authors on 27. PSF has access to an extensive, up-to-date computing environment that includes open source and commercial software engineering tools. The PSF is advised by a dedicated Facility Advisory Committee (FAC) that meets annually. Recommendations from the FAC are directed to a governing Facility Parent Oversight Committee (FPOC) that serves to ensure that the PSF continues to have the necessary resources to provide the highest quality informatics services for Cancer Center members. Demand for services is expected to increase in the next CCSG cycle due to plans to recruit in all 5 Research Programs and new demand from Cancer Center members at TU.

计算/信息学共享资源：人口研究设施 (PSF) 项目概要/摘要 PSF 在上次评审中被评为“优秀”。基于计算机的工具对于许多研究至关重要。成功，特别是那些收集大量数据或涉及复杂数据收集协议的数据。 PSF 通过提供关键的信息学基础设施和定制的、特定于项目的信息来促进 FCCC 研究癌症中心成员的信息系统，由 Eric Ross 博士和 5.5 名工作人员指导。 FTE 为成员提供了一支稳定、具有成本效益的信息系统专业人员团队，他们拥有最先进的技术适合癌症研究的最先进的软件设计和工程技能包括。开发：用于存储和操作大量调查问卷、临床、分子和样本数据；电子数据采集接口；报告生成软件；质量控制系统；支持网络的多媒体应用程序；以及提供集成和服务的系统；来自不同来源的受控数据交换是研究基础设施的重要组成部分。所有癌症中心成员都可以随时访问 PSF 开发的系统来维护数据。超过 90,000 名受试者在美国境内参加了 FCCC 研究；国际队列研究人员精通管理复杂数据库的软件工具和 2011 年至 2014 年期间，PSF 提供了 32,596 份研究报告。为四个研究项目的 38 名癌症中心成员提供了 7,125 小时的咨询时间。 2014 年向 24 名癌症中心会员提供咨询时间。其中 6,380 小时（90%）用于支持的同行评审资助的癌症中心成员为其他七个 FCCC 提供了直接信息学支持。在本周期内，CCSG 支持的机构还与临床试验办公室合作。部署、定制和集成新的核心信息学工具，以支持临床研究和 PSF 在当前期间扩展了 Fox Chase 数据仓库 (FCDW)。它现在集成了来自 228,000 名患者和研究的 41 个研究和临床系统的数据。 FCDW 促进了转化和相关领域的新合作和机会。 2011年至2015年6月，PSF贡献了117篇论文，其中PSF人员为 27. PSF 的合著者可以访问广泛的、最新的计算环境，其中包括开放的 PSF 由专门的设施咨询机构提供建议。委员会 (FAC) 每年召开一次会议，FAC 的建议将提交给管理机构。家长监督委员会 (FPOC) 旨在确保 PSF 继续拥有必要的为癌症中心成员提供最高质量的信息学服务的资源。由于计划在所有 5 个研究项目中招募人员以及新的人员，预计下一个 CCSG 周期将增加 TU 癌症中心成员的需求。