Biostatistics and Bioinformatics Core (Shared Resources

生物统计学和生物信息学核心（共享资源

基本信息

批准号：
10462708
负责人：
Eric Andrew Ross
金额：
$ 12.43万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-19 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10462708
关键词：
Achievement Behavior Bioinformatics Biometry Biostatistics Core Cancer Biology Cancer Control Research Chromosomes Clinical Clinical Informatics Clinical Investigator Clinical Trials Collaborations Computers Computing Methodologies Consultations Cytogenetic Analysis DNA sequencing Data Data Analyses Data Storage and Retrieval Database Management Systems Development Doctor of Philosophy Environment Epidemiologist Epidemiology Epigenetic Process Experimental Designs Fostering Future Genomics Goals Guidelines Health Disparities Research Health Insurance Portability and Accountability Act Informatics Information Systems Infrastructure Institution Institutional Review Boards Internet Knowledge Malignant Neoplasms Manuscripts Methods Nature Participant Phase Pilot Projects Play Population Sciences Postdoctoral Fellow Procedures Randomized Research Research Design Research Personnel Research Project Grants Research Proposals Resource Sharing Resources Retrieval Role Running Sample Size Scientist Services Statistical Computing Statistical Data Interpretation Structure System Writing anticancer research base bioinformatics tool cancer education cancer health disparity cancer prevention clinical application cost effective data access data analysis pipeline data management data pipeline data sharing design diverse data electronic data experience experimental study genetic epidemiology genomic data genomic epidemiology high throughput analysis informatics tool member multidisciplinary next generation sequencing preclinical study skills tool transcriptome sequencing user-friendly

项目摘要

PROJECT SUMMARY Biostatistics and Bioinformatics Core (Shared Resource) TUFCCC: Eric A. Ross, PhD (Co-Leader) HC: Konstantinos Krampis, PhD (Co-Leader) The overall goal of the Biostatistics and Bioinformatics Core (BBC) is to facilitate cancer disparities research at TUFCCC and HC by providing expert experimental design, bioinformatics, data management, genomics and data analysis support to TUFCCC/HC Cancer Partnership scientists. Members of the core have substantial knowledge and experience in biostatistics, bioinformatics, genomics and epidemiology as applied to cancer research. This highly interactive group of biostatisticians, bioinformatics, informaticians, geneticists and epidemiologists will serve all Partnership projects, pilot studies and cores and support future projects and pilot studies. The specific aims of the Biostatistics and Biostatistics Core are to: (1) Provide expert consultation for TUFCCC/HC Cancer Partnership investigators in the rigorous design of experiments and studies, including research proposal development, sample size determination, randomization procedures, experimental methods and plans for interim reviews and final analysis. (2) Perform statistical and bioinformatics analyses for TUFCCC/HC Cancer Partnership investigators using appropriate statistical and computing methodologies, as well as assist investigators with the writing of statistical and bioinformatics components of manuscripts and the interpretation and presentation of results. (3) Provide Informatics tools to enhance TUFCCC/HC Cancer Partnership research. Build cancer research capacity at HC by providing HC researchers with information systems that facilitate data entry, storage and retrieval. (4) Provide cost-effective, high-quality genomic and epigenetic services and expertise for the TUFCCC/HC Cancer Partnership including NextGen sequencing (e.g., DNA-Seq, RNA-Seq) as well cytogenetic analysis, chromosome and expression microarray solutions as needed. (5) Enable TUFCCC/HC investigators who may be non-technical users to easily access and manage large-scale genomic datasets and run bioinformatics data pipelines, through a user- friendly, web-browser accessible interface. By providing quantitative and genomics expertise and resources to investigators, and sharing technical capabilities, the BBC team will support the entire TUFCCC/HC Cancer Partnership and facilitate achievement of project aims and exploratory analyses beyond those stated.

项目概要生物统计学和生物信息学核心（共享资源） TUFCCC：Eric A. Ross 博士（联合领导者） HC：Konstantinos Krampis 博士（联合领导者）生物统计学和生物信息学核心 (BBC) 的总体目标是促进癌症通过提供专家实验设计，在 TUFCCC 和 HC 进行差异研究，为 TUFCCC/HC Cancer 提供生物信息学、数据管理、基因组学和数据分析支持合作科学家。核心成员拥有丰富的知识和经验生物统计学、生物信息学、基因组学和流行病学应用于癌症研究。这由生物统计学家、生物信息学家、信息学家、遗传学家组成的高度互动的团队流行病学家将为所有伙伴关系项目、试点研究和核心服务，并支持未来项目和试点研究。生物统计学和生物统计学核心的具体目标是：（1）提供专家为 TFCCC/HC 癌症合作研究人员提供严格设计咨询实验和研究，包括研究计划的制定、样本量的确定、随机化程序、实验方法以及中期审查和最终的计划分析。 (2) 对TUFCCC/HC癌症进行统计和生物信息学分析合作研究人员使用适当的统计和计算方法，以及协助研究人员撰写手稿的统计和生物信息学部分以及结果的解释和呈现。 (3) 提供信息学工具以增强 TFCCC/HC 癌症合作研究。通过提供以下内容来建立 HC 的癌症研究能力： HC 研究人员拥有可促进数据输入、存储和检索的信息系统。 (4) 为患者提供经济高效、高质量的基因组和表观遗传学服务和专业知识 TUFCCC/HC 癌症合作伙伴关系，包括 NextGen 测序（例如 DNA-Seq、RNA-Seq）根据需要提供良好的细胞遗传学分析、染色体和表达微阵列解决方案。 (5) 使可能是非技术用户的 TFCCC/HC 调查员能够轻松访问和通过用户管理大规模基因组数据集并运行生物信息学数据管道友好的、网络浏览器可访问的界面。通过向研究人员提供定量和基因组学专业知识和资源，并分享技术能力方面，BBC 团队将支持整个 TFCCC/HC 癌症合作伙伴关系促进项目目标的实现和超出规定的探索性分析。