Shared Resource: Biostatistics and Bioinformatics Facility

共享资源：生物统计学和生物信息学设施

基本信息

批准号：
9535092
负责人：
Eric Andrew Ross
金额：
$ 29.42万
依托单位：
RESEARCH INST OF FOX CHASE CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9535092
关键词：
Abbreviations Advisory Committees Bioinformatics Biological Biometry Biostatistics Shared Resource Blood Cells Cancer Biology Cancer Center Cancer Center Support Grant Cancer Control Cell Culture Techniques Cell Separation Clinical Data Clinical Investigator Clinical Trials Clinical Trials Design Collaborations Comprehensive Cancer Center Computer software Computing Methodologies Consult Consultations Data Data Analyses Development Doctor of Philosophy Ensure Environment Epigenetic Process Fox Chase Cancer Center Foxes Funding Genomics Health system Histopathology Facility Hour Imagery Interleukin-6 Investigation Laboratories Laboratory Animals Libraries Malignant Neoplasms Manuscripts Methodology Methods Molecular Monitor Observational Study Paper Parents Pathway Analysis Peer Review Phase Play Population Study Procedures Protocols documentation Publications Publishing Randomized Recommendation Reporting Research Research Activity Research Infrastructure Research Methodology Research Proposals Research Support Resource Sharing Resources Retrieval Review Committee Role Sample Size Sequence Analysis Services Surface Technology Therapeutic Transgenic Mouse Facility Universities University Hospitals animal facility cancer prevention cost effective design experimental study high throughput screening human subject imaging facilities informatics shared resource medical schools member molecular modeling peer support preclinical study programs protocol development recruit repository sound statistics translational scientist

项目摘要

COMPUTATIONAL/INFORMATICS SHARED RESOURCE: BIOSTATISTICS AND BIOINFORMATICS FACILITY (BBF) PROJECT SUMMARY/ABSTRACT BBF was rated "Outstanding" at the last review. The Biostatistics and Bioinformatics Facility (BBF) is a shared, institutional resource for biostatistics and bioinformatics collaboration and related methodological research. BBF is recognized Center-wide as a critical component of the research infrastructure and serves Cancer Center members from all five Research Programs. The BBF, with the direction of Eric Ross, PhD and a staff of 7 FTEs, provides Cancer Center members with rigorous biostatistics and bioinformatics design, analysis and interpretation of experiments and studies. Facility staff are broadly skilled in quantitative and computational methods for clinical trials, pre-clinical studies, biological experiments, translational investigations and cancer prevention and control problems. Its members embrace new problems and technologies that surface in a rapidly changing scientific environment. Facility biostatisticians play essential roles in all phases of study planning, reporting and design including sample size determination, randomization, and interim and final analyses. Bioinformaticians provide expertise for the analysis and exploration of diverse laboratory results including high throughput data. All Cancer Center members have ready access to the BBF’s coordinated and cost effective biostatistics and bioinformatics services. BBF maintains statistical and bioinformatics software packages for data analysis; visualization; sample size/power estimation; sequence analysis; pathway and network analysis; and annotation. BBF interactions with laboratory, cancer control, translational and clinical investigators have extended the interpretation of experimental data and contributed substantially to FCCC research. BBF’s members published 260 papers from 2011 to June 2015 (91% increase over 2006-June 2010). BBF members’ development of specialized biostatistics and bioinformatics methods to support Cancer Center projects resulted in 16 methodology/first author publications in clinical trial design, observational study methods and high throughput data analyses. From 2011-2014, BBF provided 39,359 hours of support to the research activities of 105 Cancer Center members. 32,565 hours were in support of peer-review-funded members from all five Research Programs. In 2014, the facility provided 9,534 consulting hours supporting 90 Cancer Center members. 7,423 hours were in support of 67 peer-reviewed members. BBF reviews the statistical soundness of all protocols involving human subjects in conjunction with the Research Review Committee. It is advised by a Facility Advisory Committee (FAC) that meets at least annually. Recommendations from the FAC are directed to a governing Facility Parent Oversight Committee (FPOC) that serves to ensure that the BBF continues to have the resources needed to provide the highest quality of quantitative services for Cancer Center members. Demand for services is expected to increase in the next CCSG cycle due to plans to recruit in all 5 Research Programs, and new demand from Cancer Center members at TU.

计算/信息学共享资源：生物统计学和生物信息学设施（BBF）项目概要/摘要 BBF 在上次审查中被评为“杰出”。用于生物统计学和生物信息学合作及相关方法学研究的机构资源。 BBF 被整个中心视为研究基础设施的重要组成部分，并为癌症服务来自 BBF 所有五个研究项目的中心成员，由 Eric Ross 博士和工作人员指导。 7 个 FTE，为癌症中心成员提供严格的生物统计学和生物信息学设计、分析和设施工作人员在定量和计算方面具有广泛的技能。临床试验、临床前研究、生物实验、转化研究和癌症的方法其成员接受出现的新问题和新技术。快速变化的科学环境。设施生物统计学家在研究的各个阶段都发挥着重要作用。规划、报告和设计，包括样本量确定、随机化以及中期和最终结果生物信息学家为分析和探索不同的实验室结果提供专业知识。包括高通量数据。所有癌症中心成员都可以随时访问 BBF 的协调和数据。 BBF 提供具有成本效益的生物统计和生物信息学服务。数据分析包；样本量/功效估计；网络分析；以及 BBF 与实验室、癌症控制、转化和临床的相互作用。研究人员扩展了实验数据的解释，并对 FCCC 做出了重大贡献 2011 年至 2015 年 6 月，BBF 成员发表了 260 篇论文（比 2006 年至 6 月增加了 91%）。 2010) BBF 成员开发专门的生物统计学和生物信息学方法来支持癌症。中心项目在临床试验设计、观察性研究方面发表了 16 篇方法论/第一作者出版物从 2011 年到 2014 年，BBF 为该项目提供了 39,359 小时的支持。 105 名癌症中心成员的研究活动 32,565 小时用于支持同行评审资助。 2014 年，该机构提供了 9,534 个小时的咨询时间，为 90 名成员提供了支持。癌症中心成员花费了 7,423 小时支持 67 位经过同行评审的成员。与研究审查相结合的涉及人类受试者的所有方案的统计健全性委员会由设施咨询委员会 (FAC) 提供建议，该委员会至少每年举行一次会议。 FAC 的建议将提交给管理机构家长监督委员会 (FPOC)，该委员会旨在确保 BBF 继续拥有提供最高质量的资源所需的资源癌症中心会员的定量服务预计未来将会增加。 CCSG 周期是由于计划在所有 5 个研究项目中招募人员以及癌症中心的新需求 T.U. 成员