Low cost, automated smartphone based assay for semen analysis

用于精液分析的低成本、基于智能手机的自动化检测

• 批准号: 10028296
• 负责人: KUMAR SUBRAMANIAN
• 金额: --
• 依托单位: PHOENIX BIOSYSTEM, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-07 至 2020-06-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10028296
• 关键词: American; Biological Assay; Capital; Cellular Phone; Clinic; Clinic Visits; Clinical; Computer Assisted; Custom; Data; Detection; Developed Countries; Developing Countries; Development; Devices; Diagnosis; Diagnostic tests; Evaluation; Feedback; Female; Fertility; Focus Groups; Freezing; Funding; Galaxy; General Hospitals; Gold; Grant; Health; Home environment; Image; Infertility; Intervention; Laboratories; Laboratory Personnel; Male Infertility; Manuals; Massachusetts; Methods; Microscopic; Modeling; Monitor; Needs Assessment; Optics; Patients; Phase; Predictive Value; Pregnancy Tests; Preparation; Process; Reporting; Reproducibility; Reproductive Health; Sampling; Seminal fluid; Sensitivity and Specificity; Slide; Small Business Innovation Research Grant; Specificity; Stains; System; Technical Expertise; Technology; Testing; Untrained Personnel; Validation; base; blind; cell motility; convolutional neural network; cost; design; infertility treatment; interest; male; male fertility; medical attention; meetings; men; microchip; neural network architecture; point-of-care diagnostics; prototype; smartphone Application; sperm analysis; sperm cell; sperm morphology; testing services

PROJECT SUMMARY Consumers are increasingly interested in knowing more about their own health. One of the most familiar direct to-consumer diagnostic tests has been the home pregnancy test. We report a practical approach towards developing a new point-of-care diagnostic test for another reproductive health need—the assessment of male fertility. Traditionally, men are less likely to seek medical attention for fertility concerns than their female partners (although millennial males are more interested in fertility testing). A delay in diagnosis of male factor infertility may prolong the infertility treatment process for the couple and result in unnecessary interventions for the female partner. Manual microscopic testing and computer-assisted semen analysis (CASA) technology are expensive and require significant technical skill to use. The idea of an at-home, affordable testing platform to screen for an abnormal semen analysis would obviate the need for a clinic visit and provide preliminary data to guide referrals. Our prototype device has been extensively tested with clinical semen samples. The preliminary results presented are robust and unbiased and patient results are based on blind evaluation of the technology by comparing our microchip results with standard methods. In this Fast Track SBIR project we will further optimize the design parameters and develop a best in class, cellphone-based semen analysis device that could be marketed to a) for home based testing and b) as an inexpensive alternative to CASA in IVF clinics.

项目摘要 消费者越来越多地了解自己的健康之一。 熟悉的直接消费者诊断测试是家庭怀孕测试 为另一个人开发新的护理诊断测试的实用方法 繁殖健康需求 - 男性生育能力的评估。 比其女性伴侣寻求医疗服务有关生育问题 对生育测试更感兴趣）。 这对夫妻的不孕治疗过程，并为他们提供不必要的干预措施 女伴侣。 手动微观测试和计算机辅助精液分析（CASA）技术是 昂贵，需要大量的技术技能。 筛查异常精液分析的平台是否可以消除对诊所访问的需求和 提供初步数据以指导推荐。 我们的原型设备已通过临床精液样品进行了扩展测试 提出的结果是坚固且公正的，患者的结果是盲目评估的低音 通过标准方法组成我们的微芯片的技术。 SBIR项目我们将进一步优化设计参数，并在课堂上开发最佳 基于手机的精液分析设备，该设备可能会被授予a）用于家庭测试和 b）作为IVF诊所CASA的廉价替代品。