Research Support Core

研究支持核心

• 批准号: 10023722
• 负责人: Gregory Evan Miller
• 金额: $ 70.99万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10023722
• 关键词: Addictive Behavior; Affect; Affective; African American; Alcohol or Other Drugs use; Behavior; Biological Assay; Biological Markers; Biometry; Brain; Capital; Centers of Research Excellence; Chronic stress; Cognitive; Collaborations; Communities; Consultations; Consumption; Data; Data Analytics; Development; Disease; Drug abuse; Drug usage; Education; Educational workshop; Etiology; Exposure to; Family; Fatty acid glycerol esters; Food; Functional Magnetic Resonance Imaging; Funding; Generations; Goals; Health; Health Services Research; Immune signaling; Immunology; Inflammation; Inflammatory; Intervention; Investigation; Low income; Mission; Motivation; National Institute of Drug Abuse; Neurobiology; Neurocognitive; Neuroimmune; Neurosciences; Participant; Peripheral; Physiological; Pilot Projects; Plant Roots; Population; Prevention; Preventive; Process; Protocols documentation; Research; Research Personnel; Research Project Grants; Research Project Summaries; Research Support; Resources; Risk; Sampling; Science; Scientist; Skin; Specific qualifier value; Specimen; Stress; Structure; System; Targeted Research; Testing; Training; Transact; Universities; Youth; cardiometabolic risk; cardiometabolism; contextual factors; data analysis pipeline; data exchange; data management; design; drug use vulnerability; emotion regulation; ethnic minority population; experience; image processing; imaging facilities; inflammatory marker; member; minority communities; multilevel analysis; network models; neural circuit; neuroimaging; next generation; prevent; programs; protocol development; psychosocial; ranpirnase; resilience; social; substance misuse; substance misuse prevention; sugar; therapy development; working group

PROJECT SUMMARY: Research Support Core We propose a Research Support Core (RSC) in the context of a P50 Research Center of Excellence: The Center for Translational and Prevention Science (CTAPS). The RSC’s overarching goal is to facilitate a new generation of research focused on (a) stress-induced alterations in brain-immune signaling that create vulnerabilities to substance misuse and cardiometabolic disease, (b) the identification of malleable protective processes that can prevent or mitigate the downstream health consequences of stress, and (c) the development of interventions for African Americans that prevent substance misuse and cardiometabolic disease. To this end, the Research Support Core (RSC) will: (a) oversee and execute analyses of neurocognitive, inflammatory, cardiometabolic, and biostatistical data collected by Center Research Projects (RPs) and Pilot Studies; (b) provide intellectual consultation to Center scientists regarding design protocols, promising targets for research and intervention, and interpretation of results; and (c) sponsor educational and training experiences for CTAPS scientists and the broader scientific community. This Core represents a continuation of a highly productive collaboration between scientists at the University of Georgia and Northwestern University, who together have established pipelines for generating inflammatory, cardiometabolic, and neuroimaging data relevant to African Americans’ substance use and overall health. The RSC comprises substantial intellectual capital and state-of-the science facilities for analysis of neuroimaging data and assaying biomarkers of inflammatory and cardiometabolic functioning. It is composed of three subscores: Neurocognitive (NCO), Inflammatory (INF), and Biostatistical (BSC). The RSC’s aims are to: (1) provide intellectual consultation to RP directors, transdisciplinary work groups, and pilot project investigators, (2) help develop protocols for collecting high-quality neuroimaging, inflammatory, and cardiometabolic data, (3) assay biospecimens for inflammatory and cardiometabolic biomarkers, (4) process and analyze data collected in neuroimaging paradigms, and (5) provide educational experiences to CTAPS scientists, mentees, and affiliates, as well as serving as a resource for the scientific community by providing education through online seminars and preconference workshops.

项目摘要：研究支持核心 我们在P50卓越研究中心的背景下提出了研究支持核心（RSC）： 翻译与预防科学中心（CTAPS）。 RSC的总体目标是促进新的 研究的生成重点是（a）应力诱导的脑免疫信号改变的改变 滥用药物和心脏代谢疾病的脆弱性，（b）可延展的受保护的识别 可以防止或减轻压力下游健康后果的过程，以及（c） 开发防止药物滥用和心脏代谢的非洲裔美国人的干预措施 疾病。为此，研究支持核心（RSC）将：（a）监督和执行分析 中心研究项目收集的神经认知，炎症，心脏代谢和生物统计数据 （RPS）和试点研究； （b）向中心科学家提供有关设计协议的智力咨询， 研究和干预的有希望的目标，以及结果的解释； （c）赞助者教育和 CTAPS科学家和更广泛的科学界的培训经验。这个核心代表 继续在佐治亚大学和 西北大学，共同建立了引起炎症的管道， 心脏代谢和神经影像学数据与非裔美国人的药物使用和整体健康有关。 RSC组成了大量的智力资本和最新的科学设施，用于分析神经影像学 炎症和心脏代谢功能的数据和分析生物标志物。它由三个 亚科：神经认知（NCO），炎症（INF）和生物统计学（BSC）。 RSC的目的是：（1） 向RP董事，跨学科工作组和试点项目调查人员提供直通咨询 （2）有助于开发用于收集高质量神经影像学，炎症和心脏代谢数据的方案，（3） 测定生物测量的炎症和心脏代谢生物标志物，（4）过程并分析收集的数据 在神经影像学范式中，（5）为科学家，受训者和 分支机构，并通过在线提供教育来充当科学界的资源 污水处理和前会议研讨会。