Harnessing Movement Variability to Treat and Prevent Motor Related Disorders

利用运动变异性来治疗和预防运动相关疾病

• 批准号: 10004062
• 负责人: NIKOLAOS STERGIOU
• 金额: $ 211.99万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004062
• 关键词: Achievement; Address; Award; Behavioral; Biology; Biomechanics; Biomedical Engineering; Biomedical Research; Centers of Research Excellence; Clinical; Clinical Investigator; Clinical Research; Core Facility; Development; Disease; Enrollment; Faculty; Foundations; Funding; Gait; Generations; Goals; Growth; Home environment; Human; Infrastructure; Institution; Intervention; Investigation; Joints; Laboratories; Longitudinal Studies; Mentors; Methodology; Motor; Movement; Nebraska; Neurologic; Noise; Parkinson Disease; Patients; Peripheral arterial disease; Phase; Pilot Projects; Positioning Attribute; Posture; Process; Prosthesis; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Scientist; Source; Specificity; System; Technology; Time; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Work; base; exoskeleton; falls; graduate student; innovation; interdisciplinary approach; member; movement analysis; neurobehavioral; neuromuscular system; prevent; professor; prototype; restoration; skeletal; success; translational scientist; undergraduate student

PROJECT SUMMARY In COBRE Phase I we established the Center for Research in Human Movement Variability (MOVCENTR) allowing the development of a strong critical mass of investigators and tremendous growth in terms of research infrastructure with world class facilities and resources such as the Biomechanics Research Building with its associated technologies and methodologies as well as the building’s upcoming expansion. In COBRE Phase II, we build on these foundational successes to maximize the likelihood of achieving an independent, sustainable, thematic, interdisciplinary center. We aim to further strengthen the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. Therefore, we propose to establish three new research cores, the Movement Analysis Core, the Nonlinear Analysis Core, and the Machining and Prototyping Core. We also aim to expand the critical mass of funded investigators supporting research in human movement variability. As such we propose four research projects that will be carried out under the Center’s umbrella. The project titles are: (1) The influence of prosthesis use on cortical activation and movement variability, (2) Longitudinal study of gait variability to predict falls in Parkinson disease, (3) Exoskeleton optimization for reducing gait variability in patients with Peripheral Artery Disease, and (4) Variability and specificity in reactive stabilization movements to diverse slip perturbations. These projects are led by strong junior investigators paired with senior clinical NIH-funded scientists as scientific advisors. Such a mentoring relationship is unique and has worked very well in enhancing the efficiency and quality of the clinical and translational research that is conducted in each research project under our thematic scientific focus.

项目摘要 在I阶段，我们建立了人类运动变异性研究中心 （Movcentr）允许发展大量的研究人员和 与世界一流的设施和资源有关的研究基础设施的巨大增长 例如生物力学研究大楼及其相关技术和 方法以及建筑物即将进行的扩展。在COBRE第二阶段，我们以 这些基本的成功，以最大程度地实现独立的可能性 可持续，主题，跨学科中心。我们旨在进一步加强基础设施 和专业知识基础，以探索人类运动变异性的机制以治疗 并防止与运动有关的疾病。因此，我们建议建立三项新研究 核心，运动分析核心，非线性分析核心以及加工和加工 原型核心。我们还旨在扩大支持的资金调查人员的关键质量 人类运动变异性研究。因此，我们提出了四个研究项目 在中心的伞下进行。项目标题是：（1）假体的影响 用于皮质激活和运动变异性，（2）收集变异性的纵向研究 预测帕金森氏病的跌倒，（3）外骨骼优化可降低对齐变异性的优化 外周动脉疾病的患者以及（4）反应性稳定的变异性和特异性 向潜水员滑动的动作。这些项目由强大的初级调查员领导 与高级NIH资助的科学家与科学顾问配对。这样的心理 关系是独一无二的，在提高效率和质量方面非常有效 根据我们的理论，在每个研究项目中进行的临床和翻译研究 科学重点。